Results 131 to 140 of about 1,085 (178)

Inulin is a promising cryo- and lyoprotectant for PEGylated lipoplexes

Journal of Controlled Release, 2005
The aim of this study was to investigate whether the oligosaccharides dextran and inulin are able to prevent aggregation of lipoplexes based on 1,2-dioleoyl-3-trimethylammonium-propane and dioleoylphosphatidyl-ethanolamine with and without distearoylphosphatidylethanolamine-polyethyleneglycol (PEGylated and nonPEGylated lipoplexes, respectively) during
Hinrichs, W L J, Sanders, N N, De Smedt, S C, Demeester, J, Frijlink, H W   +4 more
openaire   +4 more sources

Reversible self-polymerizing high Tg lyoprotectants

Cryobiology, 2002
One mode of action of protectants in the storage of biological materials is by promoting the formation of a vitrified state on cooling or drying. In the case of preservation by drying, the glassy material comprises a low water content mixture of protectant and organic material.
D R, MacFarlane, J, Pringle, G, Annat
openaire   +3 more sources

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Inulin like lyoprotectant of bovine plasma proteins concentrated by ultrafiltration

Food Research International, 2010
The growth of world demand for protein-enriched products generates a great interest in the search of new protein sources of higher nutritional value and, therefore, in the use of cutting edge technologies to achieve that goal. In this work, technologies of ultrafiltration and freeze-drying to process and obtain a protein concentrate from bovine plasma ...
Mercedes Campderros, Antonio Perez Padilla   +1 more
exaly   +2 more sources

Hemoglobin-based high-throughput assessment of lyoprotectant efficacy

Cryobiology
Biologics, including vaccines, therapeutic proteins, blood products, and cell therapies, are susceptible to degradation during drying and therefore require the incorporation of protective additives (lyoprotectants) into the processing formulation to maintain their desired biological activities after reconstitution.
Jonathan Kopechek, Ivan Klbik, Menze Ma   +2 more
exaly   +3 more sources

Physicochemical and structural insights into lyophilized mRNA-LNP from lyoprotectant and buffer screenings

Journal of Controlled Release
The surge in RNA therapeutics has revolutionized treatments for infectious diseases like COVID-19 and shows the potential to expand into other therapeutic areas. However, the typical requirement for ultra-cold storage of mRNA-LNP formulations poses significant logistical challenges for global distribution.
Yuchen, Fan, Diamanda, Rigas, Lee Joon, Kim, Feng-Peng, Chang, Nanzhi, Zang, Kristina, McKee, Christopher C, Kemball, Zhixin, Yu, Pascal, Winkler, Wan-Chih, Su, Pierce, Jessen, Greg L, Hura, Tao, Chen, Stefan G, Koenig, Karthik, Nagapudi, Dennis, Leung, Chun-Wan, Yen   +16 more
exaly   +3 more sources

Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study [PDF]

European Journal of Pharmaceutical Sciences, 2023
Recently, nanocrystal dispersions have been considered as a promising formulation strategy to improve the bioavailability of the deuterated pyrazoloquinolinone ligand DK-I-56-1 (7‑methoxy-2-(4‑methoxy-d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3 ...
Mitrović, Jelena, Jelena R. Mitrović, Lunter, Dominique, Aleksandar Vukadinović, Bjelošević Žiberna, Maja, Planinšek, Odon, Snežana D. Savić, Dominique Lunter, Knutson, Daniel E., Ahlin Grabnar, Pegi, Savić, Miroslav, Savić, Snežana, Maja Bjelošević Žiberna, Pegi Ahlin Grabnar, Sharmin, Dishary, James M. Cook, Odon Planinšek, Cook, James M., Aleksandar Kremenović, Cook, James M, Vukadinović, Aleksandar, Dishary Sharmin, Daniel E. Knutson, Kremenović, Aleksandar, Miroslav M. Savić   +24 more
exaly   +2 more sources

Lyoprotected Nanosphere Formulations for Paclitaxel Controlled Delivery

Journal of Nanoscience and Nanotechnology, 2006
The preparation and technological characterization of nanosphere formulations (NS) containing the anticancer drug paclitaxel (PTX) are reported. Poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) nanospheres (NS) were prepared by a solvent displacement method.
MUSUMECI, TERESA, Vicari L, Ventura CA, GULISANO, Massimo, PIGNATELLO, Rosario, PUGLISI, Giovanni   +5 more
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Assessing storage of stability and mercury reduction of freeze-dried Pseudomonas putida within different types of lyoprotectant [PDF]

AIP Conference Proceedings, 2017
Pseudomonas putida is a potential strain in biological treatment to remove mercury contained in the effluent of petrochemical industry due to its mercury reductase enzyme that able to reduce ionic mercury to elementary mercury. Freeze-dried P.
Ahmad Bazli, Bustary, Yana, Nuratri, Abdul Aziz, Mohd Azoddein, Faten Ahada, Mohd Azli   +3 more
exaly   +2 more sources