Results 91 to 100 of about 15,218 (253)

Ocular sequelae from the illicit use of class A drugs [PDF]

open access: yes, 2004
Aim: To highlight the changes that may take place in the visual system of the class A drug abuser. Methods: A literature review was carried out of ocular/visual sequelae of the more common class A drugs.
Firth, A.Y.
core  

Polypharmacy among anabolic-androgenic steroid users: A descriptive metasynthesis [PDF]

open access: yes, 2015
Background: As far as we are aware, no previous systematic review and synthesis of the qualitative/descriptive literature on polypharmacy in anabolic-androgenic steroid(s) (AAS) users has been published. Method: We systematically reviewed and synthesized
AJ Gruber   +74 more
core   +2 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

open access: yesFEBS Open Bio, Volume 16, Issue 2, Page 252-267, February 2026.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Germplasm Collection and Molecular Detection of Endophytic Fungi in Iranian Tall Fescue (Festuca Arundinacea Schreb.) [PDF]

open access: yes, 2001
Tall fescue is a popular pasture grass grown in many countries. A systematic endophytic fungus, Acremonium coenophialum, lives in a symbiotic association within tall fescue and may impart superior competitiveness to the plant through increased ...
Nekouei, Mojtaba Khayyam
core  

The Pathway to Proof‐of‐Concept for BNC210, a Negative Allosteric Modulator of the Alpha‐7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease

open access: yesClinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.
Abstract BNC210 is an investigational small molecule selective negative allosteric modulator of the alpha‐7 nicotinic acetylcholine receptor (α7 nAChR). It is an anxiolytic compound with a novel mechanism of action. In a series of Phase 1 clinical trials in healthy volunteers, psychometric test batteries showed that BNC210 did not cause attention ...
Paul Rolan   +7 more
wiley   +1 more source

Acute Effects of Lysergic Acid Diethylamide on Circulating Steroid Levels in Healthy Subjects [PDF]

open access: yes, 2016
Lysergic acid diethylamide (LSD) is a serotonin 5-hydroxytryptamine-2A (5-HT2A ) receptor agonist that is used recreationally worldwide. Interest in LSD research in humans waned after the 1970s, although the use of LSD in psychiatric research and ...
Armario   +56 more
core   +1 more source

I Feel I Need to Think about It: A Defence of Affective Moral Enhancement

open access: yesBioethics, Volume 40, Issue 2, Page 175-182, February 2026.
ABSTRACT Critics of affective moral enhancement generally contend that moral improvement can only be properly achieved through interventions that engage a person's rational faculties. Therefore, they view attempts to achieve moral improvement by targeting emotions as futile at best and detrimental to moral agency at worst.
Pei‐hua Huang
wiley   +1 more source

Extraction and Identification of Clavine and Lysergic Acid Alkaloids from Morning Glories [PDF]

open access: yes, 1975
Author Institution: Department of Zoology and Microbiology, Ohio UniversityWITTERS, WELDON L. Extraction and identification of clavine and lysergic acid alkaloids from morning glories. Ohio J. Sci.
Witters, Weldon L.
core  

Psychedelics Promote Structural and Functional Neural Plasticity. [PDF]

open access: yes, 2018
Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the fast ...
Barragan, Eden V   +15 more
core   +2 more sources

Effects of hallucinogenic drugs on the human heart

open access: yesFrontiers in Pharmacology
Hallucinogenic drugs are used because they have effects on the central nervous system. Their hallucinogenic effects probably occur via stimulation of serotonin receptors, namely, 5-HT2A-serotonin receptors in the brain.
Joachim Neumann   +4 more
doaj   +1 more source

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