Results 121 to 130 of about 5,663 (168)
Some of the next articles are maybe not open access.
Lysergic Acid Diethylamide: Radioimmunoassay
Science, 1973A radioimmunoassay for d -lysergic acid diethylamide (LSD) is described. Antibodies to LSD were obtained by immunizing rabbits with a conjugate of LSD and human serum albumin. The specificity of the antibody was shown by competitive binding studies.
A, Taunton-Rigby, S E, Sher, P R, Kelley
openaire +2 more sources
New England Journal of Medicine, 1968
NO drug used by man has stimulated greater public-debate than lysergic acid diethylamide (LSD). This brief review of the current status of the drug will summarize its pharmacology, medical uses and dangers. No attempt will be made to analyze in detail its alleged benefits when taken indiscriminately or under uncontrolled circumstances; these include ...
openaire +2 more sources
NO drug used by man has stimulated greater public-debate than lysergic acid diethylamide (LSD). This brief review of the current status of the drug will summarize its pharmacology, medical uses and dangers. No attempt will be made to analyze in detail its alleged benefits when taken indiscriminately or under uncontrolled circumstances; these include ...
openaire +2 more sources
IS LYSERGIC-ACID DIETHYLAMIDE A TERATOGEN ?
The Lancet, 1967Abstract A girl with a malformed right leg was born to a 19-year-old woman who had taken lysergic-acid diethylamide (L.S.D.) on the 25th day after her last menstrual period and three times between the 45th and 98th days. Her husband had also taken the drug. The child presented with the typical picture of the unilateral fibular aplastic syndrome. Since
H, Zellweger, J S, McDonald, G, Abbo
openaire +2 more sources
Biogenesis of Lysergic Acid in Ergot
Nature, 1960SEVERAL schemes have been proposed for the biogenesis of the medicinally valuable lysergic acid moiety of the ergot alkaloids1–5. Recently, it was shown by Taber and Vining6, and later verified by Baxter et al. 7, that tryptophan (β-14C) serves as a precursor for lysergic acid.
E H, TAYLOR, E, RAMSTAD
openaire +2 more sources
Total Synthesis of (+)-Lysergic Acid
Organic Letters, 2011A stereocontrolled total synthesis of (+)-lysergic acid (1) is achieved using three metal-catalyzed methodologies for the construction of three key rings. Highlights of the synthesis include Pd-catalyzed indole synthesis to form the B ring, a RCM reaction to form the D ring, and an intramolecular Heck reaction to form the C ring.
Qiang, Liu, Yanxing, Jia
openaire +2 more sources
Concerning the biogenesis of lysergic acid
Experientia, 1954Ein biogenetischer Weg zur Lysergsaure, bestehend in der Kondensation von Tryptophan mit Zitronensaure, wird vorgeschlagen.
openaire +2 more sources
Six-Step Synthesis of (±)-Lysergic Acid
The Journal of Organic Chemistry, 2023This article describes a concise synthesis of lysergic acid from simple aromatic precursors. The successful strategy relies on the coupling, dearomatization, and cyclization of a halopyridine with a 4-haloindole derivative in 6 total synthetic steps from commercial starting materials.
Brian J. Knight +2 more
openaire +2 more sources
Evaluation of Teratogenicity of Lysergic Acid Diethylamide
Nature, 1968THE concern about the psychological and physiological effects of lysergic acid diethylamide (LSD) has naturally led to the desire for experimental models to study the spectra of effects suspected to be caused by LSD. Among the recent reports of its biological effects when pregnant animal models are used, one involving rats is negative1, another2 is ...
J A, DiPaolo, H M, Givelber, H, Erwin
openaire +2 more sources
Archives of General Psychiatry, 1963
Lysergic acid diethylamide (LSD-25) was introduced as a psychomimetic drug and became a powerful investigative tool. Significant research was conducted on animals and later on humans. However, the comparison of the psychological and physiological effects of LSD-25 with those of schizophrenia could not be validated after careful study, and the concept ...
openaire +1 more source
Lysergic acid diethylamide (LSD-25) was introduced as a psychomimetic drug and became a powerful investigative tool. Significant research was conducted on animals and later on humans. However, the comparison of the psychological and physiological effects of LSD-25 with those of schizophrenia could not be validated after careful study, and the concept ...
openaire +1 more source
Indole Derivatives Related to Lysergic Acid*,†
Journal of the American Pharmaceutical Association (Scientific ed.), 1951Abstract Several new compounds related ro lysergic acid have been prepared and characterized. Four of these compounds are indole derivatives which have been prepared in quantities sdicient for pharmacological testing. Methods for the successful synthesis of the following are described: ethyl ester of 1-(3-indolylmethyl)guvacine.
F C, WHEELER, G L, JENKINS, G E, CWALINA
openaire +2 more sources