Results 1 to 10 of about 12,621 (244)

Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission. [PDF]

Proc Natl Acad Sci U S A, 2021
Significance Social behavior (SB) is a fundamental hallmark of human interaction. Repeated administration of low doses of the 5-HT2A agonist lysergic acid diethylamide (LSD) in mice enhances SB by potentiating 5-HT2A and AMPA receptor neurotransmission ...
De Gregorio D, Popic J, Enns JP, Inserra A, Skalecka A, Markopoulos A, Posa L, Lopez-Canul M, He Q, Lafferty CK, Britt JP, Comai S, Aguilar-Valles A, Sonenberg N, Gobbi G.   +14 more
europepmc   +4 more sources

The effect of lysergic acid diethylamide (LSD) on whole-brain functional and effective connectivity. [PDF]

Neuropsychopharmacology, 2023
Psychedelics have emerged as promising candidate treatments for various psychiatric conditions, and given their clinical potential, there is a need to identify biomarkers that underlie their effects. Here, we investigate the neural mechanisms of lysergic
Bedford P, Hauke DJ, Wang Z, Roth V, Nagy-Huber M, Holze F, Ley L, Vizeli P, Liechti ME, Borgwardt S, Müller F, Diaconescu AO.   +11 more
europepmc   +2 more sources

Adverse experiences resulting in emergency medical treatment seeking following the use of lysergic acid diethylamide (LSD). [PDF]

J Psychopharmacol, 2022
Background: Recreational lysergic acid diethylamide (LSD) use is growing in popularity amid increasing research interest on psychedelics and their possible therapeutic potential yet; the potent psychotropic effects of LSD may result in adverse reactions ...
Kopra EI, Ferris JA, Rucker JJ, McClure B, Young AH, Copeland CS, Winstock AR.   +6 more
europepmc   +2 more sources

The effects of Lysergic Acid Diethylamide (LSD) on the Positive Valence Systems: A Research Domain Criteria (RDoC)-Informed Systematic Review. [PDF]

CNS Drugs, 2023
Background and Objectives The renewed interest in psychedelic research provides growing evidence of potentially unique effects on various aspects of reward processing systems.
Pouyan N, Younesi Sisi F, Kargar A, Scheidegger M, McIntyre RS, Morrow JD.   +5 more
europepmc   +2 more sources

Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans. [PDF]

Psychol Med, 2023
The non-selective serotonin 2A (5-HT2A) receptor agonist lysergic acid diethylamide (LSD) holds promise as a treatment for some psychiatric disorders. Psychedelic drugs such as LSD have been suggested to have therapeutic actions through their effects on ...
Kanen JW, Luo Q, Rostami Kandroodi M, Cardinal RN, Robbins TW, Nutt DJ, Carhart-Harris RL, den Ouden HEM.   +7 more
europepmc   +2 more sources

Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers. [PDF]

Psychopharmacology (Berl), 2020
Research has shown that psychedelics, such as lysergic acid diethylamide (LSD), have profound anti-inflammatory properties mediated by 5-HT2A receptor signaling, supporting their evaluation as a therapeutic for neuroinflammation associated with ...
Family N, Maillet EL, Williams LTJ, Krediet E, Carhart-Harris RL, Williams TM, Nichols CD, Goble DJ, Raz S.   +8 more
europepmc   +2 more sources

Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD). [PDF]

Neuropharmacology, 2020
The ergoline d-lysergic acid diethylamide (LSD) is one of the most potent psychedelic drugs. 1-Acetyl-LSD (ALD-52), a derivative of LSD containing an acetyl group on the indole nitrogen, also produces psychedelic effects in humans and has about the same ...
Halberstadt AL, Chatha M, Klein AK, McCorvy JD, Meyer MR, Wagmann L, Stratford A, Brandt SD.   +7 more
europepmc   +2 more sources

Clinical Research on Lysergic Acid Diethylamide (LSD) in Psychiatry and Neuroscience [PDF]

Pharmaceuticals
Lysergic acid diethylamide (LSD) is gaining renewed interest as a potential treatment for anxiety, depression, and alcohol use disorder, with clinical trials reporting significant symptom reductions and long-lasting effects.
Hossein Omidian, Alborz Omidian
doaj   +2 more sources

The paradoxical psychological effects of lysergic acid diethylamide (LSD) [PDF]

Psychological Medicine, 2016
BackgroundLysergic acid diethylamide (LSD) is a potent serotonergic hallucinogen or psychedelic that modulates consciousness in a marked and novel way. This study sought to examine the acute and mid-term psychological effects of LSD in a controlled study.MethodA total of 20 healthy volunteers participated in this within-subjects study.
Carhart-Harris, RL, Kaelen, M, Bolstridge, M, Williams, TM, Williams, LT, Underwood, R, Feilding, A, Nutt, DJ   +7 more
openaire   +5 more sources

d-Lysergic Acid Diethylamide (LSD) as a Model of Psychosis: Mechanism of Action and Pharmacology. [PDF]

Int J Mol Sci, 2016
d-Lysergic Acid Diethylamide (LSD) is known for its hallucinogenic properties and psychotic-like symptoms, especially at high doses. It is indeed used as a pharmacological model of psychosis in preclinical research.
De Gregorio D, Comai S, Posa L, Gobbi G.
europepmc   +2 more sources