The paradoxical psychological effects of lysergic acid diethylamide (LSD) [PDF]
Psychological Medicine, 2016 BackgroundLysergic acid diethylamide (LSD) is a potent serotonergic hallucinogen or psychedelic that modulates consciousness in a marked and novel way. This study sought to examine the acute and mid-term psychological effects of LSD in a controlled study.MethodA total of 20 healthy volunteers participated in this within-subjects study.
Carhart-Harris, RL +7 more
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Acute effects of lysergic acid diethylamide (LSD) on resting brain function
Swiss Medical Weekly, 2019 Lysergic acid diethylamide (LSD) is a potent hallucinogenic substance that was extensively investigated by psychiatrists during the 1950s and 1960s.
Felix Müller, Stefan Borgwardt
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The pharmacology of d-Lysergic acid diethylamide (LSD) [PDF]
, 2017 My PhD thesis consisted of two different scientific parts, each supervised by one of my advisors, Prof. Dr. med. Matthias Liechti and Prof. Dr. sc. nat. Katharina Rentsch. One part was to develop liquid chromatography tandem mass spectrometry (LC-MS/MS) methods to measure d-lysergic acid diethylamide (LSD) and its main metabolites in plasma, serum, and
Dolder, Patrick
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The effect of lysergic acid diethylamide (LSD) on whole-brain functional and effective connectivity. [PDF]
Neuropsychopharmacology, 2023 Psychedelics have emerged as promising candidate treatments for various psychiatric conditions, and given their clinical potential, there is a need to identify biomarkers that underlie their effects. Here, we investigate the neural mechanisms of lysergic
Bedford P +11 more
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Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers. [PDF]
Psychopharmacology (Berl), 2020 Research has shown that psychedelics, such as lysergic acid diethylamide (LSD), have profound anti-inflammatory properties mediated by 5-HT receptor signaling, supporting their evaluation as a therapeutic for neuroinflammation associated with ...
Family N +8 more
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Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD). [PDF]
Neuropharmacology, 2020 The ergoline d-lysergic acid diethylamide (LSD) is one of the most potent psychedelic drugs. 1-Acetyl-LSD (ALD-52), a derivative of LSD containing an acetyl group on the indole nitrogen, also produces psychedelic effects in humans and has about the same ...
Halberstadt AL +7 more
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d-Lysergic Acid Diethylamide (LSD) as a Model of Psychosis: Mechanism of Action and Pharmacology. [PDF]
Int J Mol Sci, 2016 d-Lysergic Acid Diethylamide (LSD) is known for its hallucinogenic properties and psychotic-like symptoms, especially at high doses. It is indeed used as a pharmacological model of psychosis in preclinical research.
De Gregorio D, Comai S, Posa L, Gobbi G.
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After more than sixty years we are still unclear whether LSD has a place in clinical psychiatry
Research in Psychotherapy, 2020 Dear Editor, The use of the psychedelic Lysergic Acid Diethylamide (LSD) has again provoked scientific debate over its efficacy and safety. In the 1950s-1960s LSD was used in psychotherapy for treating depression, anxiety related to terminal cancer ...
arthur saniotis
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Biological studies of clavine alkaloids targeting CNS receptors
Frontiers in Psychiatry, 2023 In contrast to well established psychedelics such as lysergic acid diethylamide (LSD) and psilocybin, ergot alkaloids of the clavine subclass have not been thoroughly investigated, in spite of their broad occurrence in nature and their well-established ...
Nikhil R. Tasker +2 more
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A non-hallucinogenic LSD analog with therapeutic potential for mood disorders
Cell Reports, 2023 Summary: Hallucinations limit widespread therapeutic use of psychedelics as rapidly acting antidepressants. Here we profiled the non-hallucinogenic lysergic acid diethylamide (LSD) analog 2-bromo-LSD (2-Br-LSD) at more than 33 aminergic G protein-coupled
Vern Lewis +18 more
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