Results 41 to 50 of about 4,220 (134)

Trends in new psychoactive substance poisonings in the Netherlands: A 14‐year retrospective analysis (2012–2025)

Addiction, Volume 121, Issue 10, Page 2822-2832, October 2026.
Abstract Background and aims Data on the presence of new psychoactive substances (NPS) mainly originate from drug‐checking, law enforcement and wastewater analysis sources, while data on NPS poisonings are scarce. In Europe, the documented incidence rate of NPS poisonings is highest in the Netherlands.
Johanna J. Nugteren‐van Lonkhuyzen, Irma S. van den Hengel‐Koot, Claudine C. Hunault, Dylan W. de Lange, Antoinette J. H. P. van Riel, Laura Hondebrink   +5 more
wiley   +1 more source

LSD Administered as a Single Dose Reduces Alcohol Consumption in C57BL/6J Mice

Frontiers in Pharmacology, 2018
There is a substantive clinical literature on classical hallucinogens, most commonly lysergic acid diethylamide (LSD) for the treatment of alcohol use disorder.
Kenneth Alper, Kenneth Alper, Bin Dong, Relish Shah, Henry Sershen, Henry Sershen, K. Yaragudri Vinod, K. Yaragudri Vinod, K. Yaragudri Vinod   +8 more
doaj   +1 more source

Classic psychedelics do not affect T cell and monocyte immune responses

Frontiers in Psychiatry, 2023
IntroductionClassic psychedelics have been shown to exert therapeutic potential for the treatment of various psychiatric disorders, neuropsychiatric diseases, and neuronal damage.
Deborah Rudin, Deborah Rudin, Alexander Areesanan, Matthias E. Liechti, Matthias E. Liechti, Carsten Gründemann   +5 more
doaj   +1 more source

Comprehensive in vitro profiling of traditional and emerging stimulants at monoamine transporters and the 5‐HT2A receptor

British Journal of Pharmacology, Volume 183, Issue 19, Page 5871-5894, October 2026.
A pharmacological profiling of 58 synthetic stimulants of various classes at dopamine, norepinephrine, and serotonin transporters and the 5‐HT2A receptor, most showing distinct class‐dependent profiles, with some indicating a high abuse potential. Background and Purpose New psychoactive substances (NPSs) often emerge on the illicit drug market with ...
Darta Stalberga, Robert Kronstrand, Bianca Schranz, Nick van Zijl, Sebastian Karlman, Soma Aref, Tobias Rautio, Svante Vikingsson, Mattias Persson, Henrik Green   +9 more
wiley   +1 more source

Contribution of the Serotonin 5‐HT2A Receptor to the Therapeutic Effect of Psilocin on Social Behavior Deficits in Mice Repeatedly Exposed to Social Defeat Stress

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
Psilocin, the active metabolite of psilocybin, ameliorated social avoidance behavior in mice exposed to chronic social defeat stress when administered after, but not before, stress exposure via serotonin 5‐HT2A receptor activation. These findings suggest that psilocin exerts therapeutic, but not preventive, effects on stress‐induced social behavioral ...
Daisuke Ibi, Rika Takaba, Keisuke Yoshida, Ririna Kawase, Hiroko Kitagawa, Momoko Matsushita, Kana Ito, Shoya Uno, Fumiya Nishimura, Shinji Kitagaki, Masayuki Hiramatsu   +10 more
wiley   +1 more source

Development of Japanese Versions of the 4‐Item Mystical Experience Questionnaire and 7‐Item Challenging Experience Questionnaire

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
The authorized Japanese versions of the MEQ‐4 and CEQ‐7 were developed in accordance with ISPOR good practice guidelines. These brief scales enable the rapid assessment of mystical and challenging experiences among Japanese speakers. ABSTRACT Introduction Interest in therapeutic applications of psychedelics has recently resurged.
Futaba Umemura, Hiroko Kotajima‐Murakami, Justin C. Strickland, Albert Garcia‐Romeu, Matthew W. Johnson, Kazutaka Ikeda   +5 more
wiley   +1 more source

Treatment of neuropathic pain with repeated low-dose MDMA: a case report

Frontiers in Psychiatry
A 64-year-old male patient who suffered from traumatic life experiences and neuropathic pain after oncological chemotherapy was treated with medium to high doses of lysergic acid diethylamide (LSD) and high doses and microdoses of ...
Peter Gasser, Matthias E. Liechti, Friederike Holze   +2 more
doaj   +1 more source

High Awareness, Low Clarity: Knowledge of the Australian Capital Territory's Multi‐Drug Decriminalisation Reform Among People Who Use Illicit Drugs

Drug and Alcohol Review, Volume 45, Issue 6, September 2026.
ABSTRACT Introduction In October 2023, the Australian Capital Territory became the first Australian jurisdiction to decriminalise possession of small quantities of multiple illicit drugs by law, introducing an alternative, legislated pathway enabling police to divert individuals to a health education and information session or issue a $100 expiation ...
Rachel Sutherland, Connor Graham, Caitlin Elizabeth Hughes, Anna Olsen, Chris Gough, Cate King, Amy Peacock   +6 more
wiley   +1 more source

A mood disorder episode with an onset under chronic cannabis consumption and accompanied with psychotic features immediately after N, N-Dimethyltryptamine (DMT) use: a case report [PDF]

Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2011
, N-dimethyltryptamine (DMT) is a serotonin agonist hallucinogen, similar to lysergic acid diethylamide (LSD). Syntetic production of DMT as well as extraction from several plants of South American flora is possible.
Güliz Özgen, İlker Küçükparlak, Gökhan Umut, Ahmet Türkcan   +3 more
doaj  

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 345-356, August 2026.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source