Results 61 to 70 of about 4,689 (214)
Free energy calculations of the functional selectivity of 5-HT2B G protein-coupled receptor.
PLoS ONE, 2020 G Protein-Coupled Receptors (GPCRs) mediate intracellular signaling in response to extracellular ligand binding and are the target of one-third of approved drugs.
Brandon L Peters +2 more
doaj +1 more source
Lower-dose psycholytic therapy – A neglected approach
Frontiers in Psychiatry, 2022 Lysergic acid diethylamide (LSD) and similar psychoactive drugs have been used in psychotherapy since 1949, when the first clinical study with lower-dose LSD showed therapeutically relevant effects.
Torsten Passie +6 more
doaj +1 more source
Action of Steroids on Lysergic Acid Diethylamide (LSD) Metabolism.
Experimental Biology and Medicine, 1962 SummaryA method is described which permits the biotransformation of LSD by a rat liver homogenate fraction. The rate of biotransformation is reduced significantly by steroids at concentrations as low as 10-7 M. The view is expressed that steroids block the action and metabolism of LSD by interfering with the LSD-receptor relationship in the cell.
J R, BERGEN, L, PERKINS, M, HAYANO
openaire +2 more sources
Safety pharmacology of acute mescaline administration in healthy participants
British Journal of Clinical Pharmacology, EarlyView.Aims Psychedelics, including mescaline, may serve as novel treatments for depression and anxiety. However, data is scarce on the safety of mescaline. Methods The present pooled analysis included two double‐blind, randomized, placebo‐controlled studies with a total of 48 participants and 96 mescaline administrations. Single oral‐dose administrations (n =
Aaron Klaiber +4 more
wiley +1 more source
Therapeutic Use of LSD in Psychiatry: A Systematic Review of Randomized-Controlled Clinical Trials
Frontiers in Psychiatry, 2020 Lysergic acid diethylamide (LSD) was studied from the 1950s to the 1970s to evaluate behavioral and personality changes, as well as remission of psychiatric symptoms in various disorders.
Juan José Fuentes +10 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose New synthetic cannabinoid receptor agonists (SCRAs) are associated with severe adverse effects, including unexpected psychiatric symptoms. These compounds are mainly active through their potent agonism on the cannabinoid receptors CB1 and CB2.
Giorgia Corli +8 more
wiley +1 more source
Lysergic acid diethylamide (LSD) and Psilocybin for the Management of Patients with Persistent Pain: A Potential Role? [PDF]
, 2018 Recently, there has been interest in lysergic acid diethylamide (LSD) and psilocybin for depression, anxiety and fear of death in terminal illness. The aim of this review is to discuss the potential use of LSD and psilocybin for patients with persistent ...
Mark I Johnson +3 more
core +1 more source
, 2022 Here is a theoretical synthesis for a cinnamaldehyde adduct formation of a hypothetically proposed lysergamide derivative named cinnamylidene-bislysergamide or lysergic acid biscinnamylidene amide (LSBC).
Chiruta, Victor
core +1 more source
Effective Connectivity of Functionally Anticorrelated Networks Under Lysergic Acid Diethylamide [PDF]
, 2023 Background: Classic psychedelic-induced ego dissolution involves a shift in the sense of self and a blurring of the boundary between the self and the world.
Razi, Adeel; https://orcid.org/ +5 more
core +1 more source
LSD Administered as a Single Dose Reduces Alcohol Consumption in C57BL/6J Mice
Frontiers in Pharmacology, 2018 There is a substantive clinical literature on classical hallucinogens, most commonly lysergic acid diethylamide (LSD) for the treatment of alcohol use disorder.
Kenneth Alper +8 more
doaj +1 more source