Results 51 to 60 of about 4,220 (134)

A Single Dose of LSD Does Not Alter Gene Expression of the Serotonin 2A Receptor Gene (HTR2A) or Early Growth Response Genes (EGR1-3) in Healthy Subjects

Frontiers in Pharmacology, 2017
Rationale: Renewed interest has been seen in the use of lysergic acid diethylamide (LSD) in psychiatric research and practice. The repeated use of LSD leads to tolerance that is believed to result from serotonin (5-HT) 5-HT2A receptor downregulation.
Patrick C. Dolder, Edna Grünblatt, Edna Grünblatt, Edna Grünblatt, Felix Müller, Stefan J. Borgwardt, Matthias E. Liechti   +6 more
doaj   +1 more source

Psychoactive Substance Use and Associated Factors Among Adolescent Commercial Tricycle Riders in Tamale, Ghana: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Psychoactive substance use (PSU) has become a major public health concern. Many countries are alarmed by the increasing use of psychoactive substances among adolescents, and Ghana is not an exception. Aim The study assessed psychoactive substance use among adolescent commercial tricycle riders of Tamale, Northern Region, Ghana ...
Yaa Nyarko Adjeso, Zaratu Bimonka Alhassan, Joseph Lasong   +2 more
wiley   +1 more source

Synthesis of N‐Benzyl o‐Methoxy Phase I Metabolites for Use as Liquid Chromatography‐Quadrupole Time of Flight Standards

ChemistrySelect, Volume 11, Issue 30, 10 August 2026.
A novel synthetic method for three phase I o‐desmethyl NBOMe metabolites bromo‐ (3a) and iodo‐ (13b) and chloro‐ analogue (13c) was developed. LC‐QToF analysis confirmed that the synthetic standards matched the major peaks observed in urine sample screens for each of the respective halogen‐substituted metabolites indicating that the synthesised ...
Jordan Spangler, Martin R. Johnston, Peter Stockham   +2 more
wiley   +1 more source

5‐HT2A receptor agonism by tert‐leucinamide and valinamide synthetic cannabinoids: In vitro and in vivo evidence

British Journal of Pharmacology, Volume 183, Issue 16, Page 4715-4734, August 2026.
Abstract Background and Purpose New synthetic cannabinoid receptor agonists (SCRAs) are associated with severe adverse effects, including unexpected psychiatric symptoms. These compounds are mainly active through their potent agonism on the cannabinoid receptors CB1 and CB2.
Giorgia Corli, Deborah Rudin, Dino Luethi, Matthias E. Liechti, Sabrine Bilel, Matteo Marti, Henrik Green, Manuela Carla Monti, Caitlyn Norman   +8 more
wiley   +1 more source

Stability-Guided Formulation of a Light-Sensitive D-LSD Capsule for Clinical Investigation

Pharmaceutics
Background/Objectives: D-lysergic acid diethylamide (D-LSD) is under investigation as a potential therapeutic strategy for alcohol use disorder (AUD). However, the extreme light sensitivity of D-LSD presents a significant challenge in developing suitable
Bernard Do, Luc Mallet, Maxime Annereau, Danielle Libong, Audrey Solgadi, Florence Vorspan, Muriel Paul, Philippe-Henri Secretan   +7 more
doaj   +1 more source

Psychedelics in Mental Health: Opportunities and Challenges

Brain and Behavior, Volume 16, Issue 7, July 2026.
ABSTRACT Psychedelic and substance‐assisted therapies are attracting renewed scientific, clinical, and public interest as potential interventions for mental health disorders, particularly treatment‐resistant depression, post‐traumatic stress disorder, and substance use disorders.
Lena K. L. Oestreich, Nathalie M. Rieser
wiley   +1 more source

Acute Lysergic Acid Diethylamide Does Not Influence Reward-Driven Decision Making of C57BL/6 Mice in the Iowa Gambling Task

Frontiers in Pharmacology, 2020
While interest in psychedelic drugs in the fields of psychiatry and neuroscience has re-emerged in recent last decades, the general understanding of the effects of these drugs remains deficient.
Lauri V. Elsilä, Nuppu Korhonen, Petri Hyytiä, Esa R. Korpi   +3 more
doaj   +1 more source

Recreational Drug Use at a Music Festival: A Dual Approach Using Hair Biomarkers Analysis and Participant Self‐Reported Drug Use

Drug Testing and Analysis, Volume 18, Issue 7, Page 831-840, July 2026.
Combined self‐report and hair analysis in festival attendees (n = 249) revealed substantial discrepancies in drug use reporting, particularly for stimulants and dissociatives. This integrated approach enhances detection of poly‐drug use and provides a more reliable basis for monitoring and harm‐reduction strategies.
A. Y. Simão, T. Rosado, M. Barroso, M. Andraus, E. Gallardo   +4 more
wiley   +1 more source

Vaccination Coverage and Prevention Counselling for Vaccine‐Preventable STIs Among HIV PrEP Users in São Paulo, Brazil: A Retrospective Cohort Study

Journal of the International AIDS Society, Volume 29, Issue S2, July 2026.
ABSTRACT Introduction HIV pre‐exposure prophylaxis (PrEP) users may be disproportionately vulnerable to sexually transmitted infections (STIs) in general, including several that are vaccine‐preventable. Understanding immunization patterns in this population is, therefore, crucial. However, data on vaccination coverage among Brazilian PrEP users remains
Marjorie Marini Rapozo, Amanda Nazareth Lara, Victor Cabelho Passarelli, Laísa Rivas Dapousa Ramos, Patricia Silva Montes, Camila de Melo Picone, Angela Carvalho Freitas   +6 more
wiley   +1 more source

The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules

Cell Reports
Summary: Increasing global concerns about psychoactive substance addiction and psychotic disorders highlight the need for comprehensive research into the structure-function relationship governing ligand recognition between these substances and their ...
Kexin Jiang, You Zheng, Liting Zeng, Ling Wang, Fei Li, Jun Pu, Yingli Lu, Suwen Zhao, Fei Xu   +8 more
doaj   +1 more source