Results 201 to 210 of about 15,218 (253)
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New England Journal of Medicine, 1968
NO drug used by man has stimulated greater public-debate than lysergic acid diethylamide (LSD). This brief review of the current status of the drug will summarize its pharmacology, medical uses and dangers. No attempt will be made to analyze in detail its alleged benefits when taken indiscriminately or under uncontrolled circumstances; these include ...
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NO drug used by man has stimulated greater public-debate than lysergic acid diethylamide (LSD). This brief review of the current status of the drug will summarize its pharmacology, medical uses and dangers. No attempt will be made to analyze in detail its alleged benefits when taken indiscriminately or under uncontrolled circumstances; these include ...
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Total synthesis of (+)-lysergic acid
The Journal of Antibiotics, 2017A total synthesis of (+)-lysergic acid, which features the C-C bond formation between C10 and C11 via cleavage of an aziridine ring, was accomplished.
Rentaro Kanno +3 more
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Archives of General Psychiatry, 1963
Lysergic acid diethylamide (LSD-25) was introduced as a psychomimetic drug and became a powerful investigative tool. Significant research was conducted on animals and later on humans. However, the comparison of the psychological and physiological effects of LSD-25 with those of schizophrenia could not be validated after careful study, and the concept ...
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Lysergic acid diethylamide (LSD-25) was introduced as a psychomimetic drug and became a powerful investigative tool. Significant research was conducted on animals and later on humans. However, the comparison of the psychological and physiological effects of LSD-25 with those of schizophrenia could not be validated after careful study, and the concept ...
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Structural Analogs of Lysergic Acid
Journal of Pharmaceutical Sciences, 1971Abstract In the course of work on the preparation of the sulfur isosters (I a ) of lysergic acid (I b ), a literature search was made for other analogs of lysergic acid to see what types of molecular modification had already been applied to this structure.
E, Campaigne, D R, Knapp
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Total Synthesis of (+)-Lysergic Acid
Organic Letters, 2011A stereocontrolled total synthesis of (+)-lysergic acid (1) is achieved using three metal-catalyzed methodologies for the construction of three key rings. Highlights of the synthesis include Pd-catalyzed indole synthesis to form the B ring, a RCM reaction to form the D ring, and an intramolecular Heck reaction to form the C ring.
Qiang, Liu, Yanxing, Jia
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Nicotinic Acid Modified Lysergic Acid Diethylamide Psychosis
Journal of Mental Science, 1955Theoretical models ranging from neurological to analytical have been introduced in the hope of providing new insights into psychopathology. The flesh and blood model is of more recent origin in this field. The experimental or model psychosis results from giving “normals” drugs which bring about a psychotic-like experience for a few hours.
N, AGNEW, A, HOFFER
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Drug and Therapeutics Bulletin, 1965
Extremely small doses of lysergide (lysergic acid diethylamide, LSD 25) have profound effects upon mental function: 50 micrograms by mouth are active in most subjects. The effects include psychological disturbances and the development of impressive changes in perception, including visual hallucinations.1 The ‘model psychoses’ induced by the drug have ...
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Extremely small doses of lysergide (lysergic acid diethylamide, LSD 25) have profound effects upon mental function: 50 micrograms by mouth are active in most subjects. The effects include psychological disturbances and the development of impressive changes in perception, including visual hallucinations.1 The ‘model psychoses’ induced by the drug have ...
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Indole Derivatives Related to Lysergic Acid*,†
Journal of the American Pharmaceutical Association (Scientific ed.), 1951Abstract Several new compounds related ro lysergic acid have been prepared and characterized. Four of these compounds are indole derivatives which have been prepared in quantities sdicient for pharmacological testing. Methods for the successful synthesis of the following are described: ethyl ester of 1-(3-indolylmethyl)guvacine.
F C, WHEELER, G L, JENKINS, G E, CWALINA
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Nonpsychic Effects of Lysergic Acid Diethylamide
Annals of Internal Medicine, 1967Excerpt The acute and the chronic psychotomimetic potentials of the hallucinogen lysergic acid diethylamide (LSD) have been documented (1).
K, Hirschhorn, M M, Cohen
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1958
Abstract : Preliminary studies suggest that there is a correlation between psychotomimetic drugs and rhinencephalic paroxysmal activity. One important observation is that in two of the three studies done thus far there occurred dramatic septal 'spiking', as seen in schizophrenic patients after they have received 250 gamma per kilo EA-1476.
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Abstract : Preliminary studies suggest that there is a correlation between psychotomimetic drugs and rhinencephalic paroxysmal activity. One important observation is that in two of the three studies done thus far there occurred dramatic septal 'spiking', as seen in schizophrenic patients after they have received 250 gamma per kilo EA-1476.
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