Results 21 to 30 of about 5,934 (217)

Comparative Pharmacological Effects of Lisuride and Lysergic Acid Diethylamide Revisited. [PDF]

ACS Pharmacol Transl Sci
Lisuride is a non-psychedelic serotonin (5-HT) 2A receptor (5-HT2A) agonist and analogue of the psychedelic lysergic acid diethylamide (LSD). Lisuride also acts as an agonist at the serotonin 1A receptor (5-HT1A), a property known to counter psychedelic ...
Glatfelter GC, Pottie E, Partilla JS, Stove CP, Baumann MH.   +4 more
europepmc   +3 more sources

The Theoretical Synthesis and in silico Modelling of Lysergic Acid Biscinnamylidene Amide from the Adduct Formation of d-Lysergic Acid Amide and Cinnamaldehyde

, 2022
Here is a theoretical synthesis for a cinnamaldehyde adduct formation of a hypothetically proposed lysergamide derivative named cinnamylidene-bislysergamide or lysergic acid biscinnamylidene amide (LSBC).
Chiruta, Victor
core   +1 more source

An open-label pilot trial assessing tolerability and feasibility of LSD microdosing in patients with major depressive disorder (LSDDEP1)

Pilot and Feasibility Studies, 2023
Background Globally, an estimated 260 million people suffer from depression [1], and there is a clear need for the development of new, alternative antidepressant therapies.
Carina Joy Donegan, Dimitri Daldegan-Bueno, Rachael Sumner, David Menkes, William Evans, Nicholas Hoeh, Frederick Sundram, Lisa Reynolds, Rhys Ponton, Alana Cavadino, Todd Smith, Partha Roop, Nathan Allen, Binu Abeysinghe, Darren Svirskis, Anna Forsyth, Mahima Bansal, Suresh Muthukumaraswamy   +17 more
doaj   +1 more source

Acute effects of lysergic acid diethylamide (LSD) on resting brain function

Swiss Medical Weekly, 2019
Lysergic acid diethylamide (LSD) is a potent hallucinogenic substance that was extensively investigated by psychiatrists during the 1950s and 1960s.
Felix Müller, Stefan Borgwardt
doaj   +1 more source

Lysergic Acid Diethylamide [PDF]

BMJ, 1966
  +10 more sources

Effective Connectivity of Functionally Anticorrelated Networks Under Lysergic Acid Diethylamide [PDF]

, 2023
Background: Classic psychedelic-induced ego dissolution involves a shift in the sense of self and a blurring of the boundary between the self and the world.
Razi, Adeel; https://orcid.org/, Vollenweider, Franz X; https://orcid.org/, Preller, Katrin H; https://orcid.org/, Egan, Gary F, Novelli, Leonardo, Stoliker, Devon; https://orcid.org/   +5 more
core   +1 more source

Classical and non-classical psychedelic drugs induce common network changes in human cortex

NeuroImage, 2023
The neurobiology of the psychedelic experience is not fully understood. Identifying common brain network changes induced by both classical (i.e., acting at the 5-HT2 receptor) and non-classical psychedelics would provide mechanistic insight into state ...
Rui Dai, Tony E. Larkin, Zirui Huang, Vijay Tarnal, Paul Picton, Phillip E. Vlisides, Ellen Janke, Amy McKinney, Anthony G. Hudetz, Richard E. Harris, George A. Mashour   +10 more
doaj   +1 more source

Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases [PDF]

, 2014
A double-blind, randomized, active placebo-controlled pilot study was conducted to examine safety and efficacy of lysergic acid diethylamide (LSD)-assisted psychotherapy in 12 patients with anxiety associated with life-threatening diseases.
Doblin, Rick, Yazar-Klosinski, Berra, Passie, Torsten, Brenneisen, Rudolf, Brenneisen, Rudolf Max, Gasser, Peter, Holstein, Dominique, Michel, Yvonne, Holstein, Dominique Hans   +8 more
core   +1 more source

Persisting Reductions in Cannabis, Opioid, and Stimulant Misuse After Naturalistic Psychedelic Use: An Online Survey

Frontiers in Psychiatry, 2020
BackgroundObservational data and preliminary studies suggest serotonin 2A agonist psychedelics may hold potential in treating a variety of substance use disorders (SUDs), including opioid use disorder (OUD).AimsThe study aim was to describe and analyze ...
Albert Garcia-Romeu, Alan K. Davis, Alan K. Davis, Earth Erowid, Fire Erowid, Roland R. Griffiths, Roland R. Griffiths, Matthew W. Johnson   +7 more
doaj   +1 more source

Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD

eLife, 2021
Psychoactive drugs can transiently perturb brain physiology while preserving brain structure. The role of physiological state in shaping neural function can therefore be investigated through neuroimaging of pharmacologically induced effects.
Joshua B Burt, Katrin H Preller, Murat Demirtas, Jie Lisa Ji, John H Krystal, Franz X Vollenweider, Alan Anticevic, John D Murray   +7 more
doaj   +1 more source