Results 81 to 90 of about 8,921 (227)

A Single Dose of LSD Does Not Alter Gene Expression of the Serotonin 2A Receptor Gene (HTR2A) or Early Growth Response Genes (EGR1-3) in Healthy Subjects

Frontiers in Pharmacology, 2017
Rationale: Renewed interest has been seen in the use of lysergic acid diethylamide (LSD) in psychiatric research and practice. The repeated use of LSD leads to tolerance that is believed to result from serotonin (5-HT) 5-HT2A receptor downregulation.
Patrick C. Dolder, Edna Grünblatt, Edna Grünblatt, Edna Grünblatt, Felix Müller, Stefan J. Borgwardt, Matthias E. Liechti   +6 more
doaj   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Acute Lysergic Acid Diethylamide Does Not Influence Reward-Driven Decision Making of C57BL/6 Mice in the Iowa Gambling Task

Frontiers in Pharmacology, 2020
While interest in psychedelic drugs in the fields of psychiatry and neuroscience has re-emerged in recent last decades, the general understanding of the effects of these drugs remains deficient.
Lauri V. Elsilä, Nuppu Korhonen, Petri Hyytiä, Esa R. Korpi   +3 more
doaj   +1 more source

Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs) [PDF]

, 2015
N-2-methoxybenzyl-phenethylamines (NBOMe drugs) are newly used psychoactive substances with poorly defined pharmacological properties. The aim of the present study was to characterize the receptor binding profiles of a series of NBOMe drugs compared with
Buchy, Danièle, Hoener, Marius C., Liechti, Matthias E., Luethi, Dino, Reinisch, Julian, Rickli, Anna   +5 more
core   +1 more source

Effectiveness of School‐Based Resilience Interventions on Adolescent Tobacco, Alcohol, and Illicit Substance Use: A Meta‐Analysis

Journal of School Health, Volume 96, Issue 4, April 2026.
ABSTRACT BackgroundResilience is a key protective factor in mitigating substance use behaviors in adolescence, but the effectiveness of school‐based resilience interventions remains unclear. MethodsRandomized and quasi‐experimental studies evaluating school‐based resilience interventions for tobacco, alcohol, or illicit substance use among students ...
Jisoo Chae, Hyekyeong Kim
wiley   +1 more source

Practical Applications of Secondary/Extractive Electrospray Ionization (SESI): A Versatile Tool for Real‐Time Chemical Analysis

Mass Spectrometry Reviews, Volume 45, Issue 2, Page 392-428, March/April 2026.
ABSTRACT In the 1980s, researchers discovered the remarkable ability of electrospray plumes to effectively ionize gas‐phase molecules via secondary ionization. Around 20 years later—coinciding with the ambient mass spectrometry revolution—secondary electrospray ionization (SESI) and extractive electrospray ionization (EESI) coupled to mass spectrometry
Xin Luo, Huiling Wang, Xiaolan Hu, Sasho Gligorovski, Xue Li, Pablo Sinues   +5 more
wiley   +1 more source

Class A drug abuse: an ophthalmologist's problem? [PDF]

, 2005
[First Paragraph] The 2002/3 British Crime Survey reported that 3% of all 16 to 59 year olds (equating to around one million people) had used a class A drug in the last year.
Firth, A.Y.
core   +1 more source

Incidents of sudden death during restraint of agitated individuals in Sweden between 1992 and 2024

Journal of Forensic Sciences, Volume 71, Issue 2, Page 821-836, March 2026.
Abstract Restraint‐related sudden deaths in agitated individuals raise complex questions at the intersection of medicine and law. Hyperactive delirium with extreme agitation as well as positional asphyxia due to restraint have been proposed to account for these deaths. However, the exact physiological mechanisms responsible and to what extent restraint
Alexander Tyr, Erik Lindeman, Fredrik Tamsen, Ingemar Thiblin, Brita Zilg   +4 more
wiley   +1 more source

Ocular sequelae from the illicit use of class A drugs [PDF]

, 2004
Aim: To highlight the changes that may take place in the visual system of the class A drug abuser. Methods: A literature review was carried out of ocular/visual sequelae of the more common class A drugs.
Firth, A.Y.
core  

Epidemiology of Hallucinogen Microdosing Among Young Adults in the United States: A National Study

Drug and Alcohol Review, Volume 45, Issue 3, March 2026.
ABSTRACT Introduction This paper aimed to determine the prevalence, demographic correlates and co‐occurring substance use patterns of hallucinogen microdosing among young adults in the United States. Methods Design: Cross‐sectional analysis of data from a nationally‐representative cohort study collected in 2022–2023.
Katherine M. Keyes, Yvonne Terry‐McElrath, Megan E. Patrick   +2 more
wiley   +1 more source