Characterization of transcription profile and structural properties of avian NK-lysin
Poultry Science, 2020 This study aimed to determine the transcription profile of NK-lysin gene in native chickens. Moreover, it was targeted toward determining the primary, three-dimensional, and molecular dynamic structures of NK-lysin and granulysin peptides to understand ...
Maged M. Mahmoud, Haitham A. Yacoub
doaj +2 more sources
Porcine Recombinant NK-Lysin Inhibits the Growth and Metastasis of Murine Hepatocellular Carcinoma In Vivo [PDF]
MoleculesPorcine recombinant NK-lysin (prNK-lysin) has been shown to inhibit the proliferation and metastasis of hepatocellular carcinoma (HCC) cells in vitro. However, its effects on the proliferation and metastasis of HCC cells in vivo remain unclear.
Kuohai Fan +7 more
doaj +2 more sources
Molecular Cloning and Functional Analysis of Holin and Endolysin From Escherichia Phage UE‐M6 as Potential Antibacterial Agents [PDF]
MicrobiologyOpenThe rise of antibiotic‐resistant bacteria has intensified the search for alternative antibacterial strategies. Bacteriophage (phage) therapy is gaining attention as a promising approach, utilizing phage‐derived proteins such as holins and endolysins to ...
Hira Niaz, Mikael Skurnik, Fazal Adnan
doaj +2 more sources
Recombinant of the Staphylococcal Bacteriophage Lysin CHAPk and Its Elimination against Streptococcus agalactiae Biofilms [PDF]
Microorganisms, 2020 Bovine mastitis is the most important infectious disease, causing significant losses in the dairy industry, in which Streptococcus agalactiae is a major pathogen.
Yuxue Shan +8 more
doaj +2 more sources
Wound-Healing Potential of Engineered Lysin GRC-ML07 in Pseudomonas aeruginosa Infected Wounds in Immunocompromised Mice [PDF]
AntibioticsObjectives: The study aimed to evaluate the antibacterial and wound-healing potential of the engineered lysin GRC-ML07 in a mouse model of full-thickness wounds infected with multidrug-resistant Pseudomonas aeruginosa under immunosuppression.
Mariam Abdulkadieva +13 more
doaj +2 more sources
Characterization of LysBM1, a novel high-penetrating phage lysin targeting enterohemorrhagic Escherichia coli [PDF]
Frontiers in Veterinary ScienceWe investigated the lytic activity of the bacteriophage endolysin (lysin) LysBM1, which has a predicted molecular mass of ~25 kDa and is encoded by an enterohemorrhagic Escherichia coli (EHEC) phage. LysBM1 was over expressed in Pichia pastoris GS115 and
Haitao Liu +6 more
doaj +2 more sources
Development of a novel chimeric lysin to combine parental phage lysin and cefquinome for preventing sow endometritis after artificial insemination [PDF]
Veterinary ResearchSow endometritis is usually caused by multiple species of pathogenic bacteria. Numerous isolates from endometritis patients have developed antimicrobial resistance. Thus, novel antibacterial agents and strategies to combat endometritis are needed.
Xin-xin Li +8 more
doaj +2 more sources
Phage lysin to control the overgrowth of normal flora in processed sputum samples for the rapid and sensitive detection of
BMC Infectious Diseases, 2013 Background Phage lysin, extracted from three bacteriophages was used in place of antibiotics to control the overgrowth of normal flora in processed sputum samples leading to the sensitive detection of Mycobacterium tuberculosis using diagnostic ...
Subramanyam Balaji +3 more
doaj +2 more sources
Identification and Characterization of a Novel Prophage Lysin against Streptococcus dysgalactiae [PDF]
MoleculesStreptococcus dysgalactiae infection can cause bovine mastitis and lead to huge economic losses for the dairy industry. The abuse of antibiotics has resulted in growing drug resistance of S.
Linan Xu +7 more
doaj +2 more sources
Engineered Lysin-Derived Peptide as a Potent Antimicrobial for Acne Vulgaris [PDF]
AntibioticsBackground/Objectives: Acne vulgaris is a skin disorder that affects millions worldwide, with Cutibacterium acnes playing a key role in its inflammation. Antibiotics reduce C.
Uri Sela +2 more
doaj +2 more sources