Polycationic Peptide Engineering of Phage Endolysins Expands Host Range and Enhances Antibacterial and Antibiofilm Activities Against Bacillus Species. [PDF]
Biotechnol BioengABSTRACT The exponential rise in antimicrobial resistance has highlighted the urgent need for the development of alternative antibacterial strategies, including phage‐derived and engineered protein agents such as endolysins and artilysins. In this study, we report the rational design, expression, and functional characterization of novel artilysins ...
Ansari F, Tarushi, Nagar V.
europepmc +2 more sources
Bacteriophage lysin mediates the binding of streptococcus mitis to human platelets through interaction with fibrinogen. [PDF]
PLoS Pathogens, 2010 The binding of bacteria to human platelets is a likely central mechanism in the pathogenesis of infective endocarditis. We have previously found that platelet binding by Streptococcus mitis SF100 is mediated by surface components encoded by a lysogenic ...
Ho Seong Seo +5 more
doaj +1 more source
Lysine Ethylation by Histone Lysine Methyltransferases [PDF]
ChemBioChem, 2019 AbstractBiomedicinally important histone lysine methyltransferases (KMTs) catalyze the transfer of a methyl group from S‐adenosylmethionine (AdoMet) cosubstrate to lysine residues in histones and other proteins. Herein, experimental and computational investigations on human KMT‐catalyzed ethylation of histone peptides by using S‐adenosylethionine ...
Abbas H. K. Al Temimi +7 more
openaire +4 more sources
Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni. [PDF]
PLoS ONE, 2017 Bovine NK-lysins, which are functionally and structurally similar to human granulysin and porcine NK-lysin, are predominantly found in the granules of cytotoxic T-lymphocytes and NK-cells.
Rohana P Dassanayake +4 more
doaj +1 more source
Distinct mode of action of a highly stable, engineered phage lysin killing Gram-negative bacteria
Microbiology Spectrum, 2023 Therapeutic options to treat bacterial infections caused by Gram-negative pathogens are limited due to the spread of multidrug resistance. Protein engineering of phage-derived lysins can play a key role in the search for new antimicrobial compounds ...
Hans Gerstmans +15 more
doaj +1 more source
Microbiology Spectrum, 2023 Staphylococcus aureus often leads to severe skin infections. However, S. aureus is facing a crisis of antibiotic resistance. The combination of phage and antibiotics is effective for drug-resistant S. aureus infections.
Xiao-chao Duan +5 more
doaj +1 more source
Scientific Reports, 2022 Lysin of bacteriophages isolated from a particular ecosystem could be inducted as a bio-controlling tool against the inhabiting pathogenic bacterial strains.
Ramya Ramadoss +4 more
doaj +1 more source
Characterization of transcription profile and structural properties of avian NK-lysin
Poultry Science, 2020 This study aimed to determine the transcription profile of NK-lysin gene in native chickens. Moreover, it was targeted toward determining the primary, three-dimensional, and molecular dynamic structures of NK-lysin and granulysin peptides to understand ...
Maged M. Mahmoud, Haitham A. Yacoub
doaj +1 more source
Thermosensitive Hydrogel Wound Dressing Loaded with Bacteriophage Lysin LysP53
Viruses, 2022 Wound infections are prone to attacks from infectious pathogens, including multidrug resistant bacteria that render conventional antimicrobials ineffective.
Changchang Li +6 more
doaj +1 more source
Indirect sexual selection drives rapid sperm protein evolution in abalone
eLife, 2019 Sexual selection can explain the rapid evolution of fertilization proteins, yet sperm proteins evolve rapidly even if not directly involved in fertilization.
Damien Beau Wilburn +3 more
doaj +1 more source