Evaluation of the Therapeutic Effect of a Bovine-Derived Klebsiella pneumoniae Phage Endolysin on Mouse Mastitis Models [PDF]
MicroorganismsMultidrug-resistant hypervirulent Klebsiella pneumoniae caused by the improper use of antibiotics has become a major threat to the dairy industry and public health, posing a major challenge to the treatment of bovine mastitis.
Zhuangkan Yan +11 more
doaj +2 more sources
Engineered Lysins With Customized Lytic Activities Against Enterococci and Staphylococci
Frontiers in Microbiology, 2020 The emergence of multidrug-resistant bacteria has made minor bacterial infections incurable with many existing antibiotics. Lysins are phage-encoded peptidoglycan hydrolases that have demonstrated therapeutic potential as a novel class of antimicrobials.
Boon Chong Goh +2 more
exaly +3 more sources
Antibiotics, 2021 Bacteriophage-encoded lysins are an emerging class of antibacterial enzymes based on peptidoglycan degradation. The modular composition of lysins is a hallmark feature enabling optimization of antibacterial and pharmacological properties by engineering ...
Rob Lavigne +2 more
exaly +3 more sources
Molecular Cloning and Functional Analysis of Holin and Endolysin From Escherichia Phage UE‐M6 as Potential Antibacterial Agents [PDF]
MicrobiologyOpenThe rise of antibiotic‐resistant bacteria has intensified the search for alternative antibacterial strategies. Bacteriophage (phage) therapy is gaining attention as a promising approach, utilizing phage‐derived proteins such as holins and endolysins to ...
Hira Niaz, Mikael Skurnik, Fazal Adnan
doaj +2 more sources
Wound-Healing Potential of Engineered Lysin GRC-ML07 in Pseudomonas aeruginosa Infected Wounds in Immunocompromised Mice [PDF]
AntibioticsObjectives: The study aimed to evaluate the antibacterial and wound-healing potential of the engineered lysin GRC-ML07 in a mouse model of full-thickness wounds infected with multidrug-resistant Pseudomonas aeruginosa under immunosuppression.
Mariam Abdulkadieva +13 more
doaj +2 more sources
Engineered Bacteriophage Lysins as Novel Anti-Infectives
Frontiers in Microbiology, 2014 Bacteriophage lysins, the highly evolved special peptidoglycan hydrolases, have long been demonstrated to be an effective enzybiotics in various infectious models. The modular structure of lysins makes it possible to design bioengineered lysins that have
Hang Yang, Junping Yu, Wei Hongping
exaly +3 more sources
New Insight Into the Biological Activity of Salmo salar NK-Lysin Antimicrobial Peptides
Frontiers in ImmunologyNK-lysin is a potent antimicrobial peptide (AMP) with antimicrobial activity against bacteria, fungi, viruses, and parasites. NK-lysin is a type of granulysin, a member of the saposin-like proteins family first isolated from a pig’s small intestine.
Natacha Santibáñez +2 more
exaly +3 more sources
Examining the Effects: Lack of Impact by Endolysin and Phage Treatment on Rotifer and Larvae Microbiota [PDF]
AntibioticsBackground: Bacteriophages and phage-derived lytic enzymes are increasingly considered to be targeted antimicrobial tools in aquaculture; however, their compatibility with non-target microbial communities under hatchery-relevant conditions remains ...
Jaime Romero +6 more
doaj +2 more sources
Second-generation lysocins as therapeutics for treating Pseudomonas aeruginosa infections [PDF]
Antimicrobial Agents and ChemotherapyPseudomonas aeruginosa is a leading cause of nosocomial infections, including pneumonia and urinary tract infections, and the primary cause of morbidity and mortality in cystic fibrosis patients.
Ryan D. Heselpoth +2 more
doaj +2 more sources
Characterization and Functional Evaluation of NK-lysin from Clownfish (Amphiprion ocellaris)
Fishes, 2023 In previous studies, natural killer lysin (NK-lysin) emerged as a crucial antimicrobial peptide (AMP) discharged by NK cells and CTLs. The sequence of NK-lysin was cloned and discovered in some fishes, but its function remains unclear.
Dapeng Yu +9 more
doaj +1 more source