Results 21 to 30 of about 14,811 (174)

Lysine Succinylation and Lysine Malonylation in Histones

Molecular & Cellular Proteomics, 2012
Histone protein post-translational modifications (PTMs) are significant for gene expression and DNA repair. Here we report the identification and validation of a new type of PTM in histones, lysine succinylation. The identified lysine succinylated histone peptides were verified by MS/MS of synthetic peptides, HPLC co-elution, and isotopic labeling.
Zhongyu, Xie, Junbiao, Dai, Lunzhi, Dai, Minjia, Tan, Zhongyi, Cheng, Yeming, Wu, Jef D, Boeke, Yingming, Zhao   +7 more
openaire   +2 more sources

Direct Lytic Agents: Novel, Rapidly Acting Potential Antimicrobial Treatment Modalities for Systemic Use in the Era of Rising Antibiotic Resistance

Frontiers in Microbiology, 2022
Direct lytic agents (DLAs) are novel antimicrobial compounds with unique mechanisms of action based on rapid cell wall destabilization and bacteriolysis.
Raymond Schuch, Cara Cassino, Xavier Vila-Farres   +2 more
doaj   +1 more source

PaP1, a Broad-Spectrum Lysin-Derived Cationic Peptide to Treat Polymicrobial Skin Infections

Frontiers in Microbiology, 2022
Most skin infections, including those complicating burns, are polymicrobial involving multiple causative bacteria. Add to this the fact that many of these organisms may be antibiotic-resistant, and a simple skin lesion or burn could soon become life ...
Ryan D. Heselpoth, Chad W. Euler, Chad W. Euler, Chad W. Euler, Vincent A. Fischetti   +4 more
doaj   +1 more source

Bioinformatics Analysis, Prokaryotic Expression and Biological Activity of Lysin from Vibrio parahaemolyticus Phage vB_VpP_1 [PDF]

Shipin Kexue
To study the in vitro cleavage effect of a recombinant lysin from bacteriophage vB_VpP_1 on Vibrio parahaemolyticus, the gp32 gene fragment of vB_VpP_1 was identified as a lysin gene according to the results of whole-genome sequencing (WGS) and ...
ZHANG Defu, YANG Wenjing, LIU Ke, LIU Qingqing, BAI Wutong, LI Fan, LÜ Xinran, BAI Xue, TAN Xiqian, LI Xuepeng, LI Jianrong
doaj   +1 more source

A second endolysin gene is fully embedded in-frame with the lysA gene of mycobacteriophage Ms6. [PDF]

PLoS ONE, 2011
Mycobacteriophages are dsDNA viruses that infect mycobacterial hosts. The mycobacteriophage Ms6 accomplishes lysis by producing two cell wall hydrolytic enzymes, Lysin A (LysA) that possesses a central peptidoglycan recognition protein (PGRP) super ...
Maria João Catalão, Catarina Milho, Filipa Gil, José Moniz-Pereira, Madalena Pimentel   +4 more
doaj   +1 more source

Phage vB_PaeS-PAJD-1 Rescues Murine Mastitis Infected With Multidrug-Resistant Pseudomonas aeruginosa

Frontiers in Cellular and Infection Microbiology, 2021
Pseudomonas aeruginosa is a Gram-negative pathogen that causes a variety of infections in humans and animals. Due to the inappropriate use of antibiotics, multi-drug resistant (MDR) P. aeruginosa strains have emerged and are prevailing.
Zhaofei Wang, Yibing Xue, Ya Gao, Mengting Guo, Yuanping Liu, Xinwei Zou, Yuqiang Cheng, Jingjiao Ma, Hengan Wang, Jianhe Sun, Yaxian Yan   +10 more
doaj   +1 more source

A lysin to kill

eLife, 2016
An enzyme produced by a bacteriophage can enter human cells and kill intracellular Streptococcus pyogenes.
Anthony O Gaca, Michael S Gilmore
openaire   +5 more sources

Treating Bacterial Infections with Bacteriophage-Based Enzybiotics: In Vitro, In Vivo and Clinical Application

Antibiotics, 2021
Over the past few decades, we have witnessed a surge around the world in the emergence of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and misuse of antibiotics as well as a relative lack of new drug classes in
Katarzyna M. Danis-Wlodarczyk, Daniel J. Wozniak, Stephen T. Abedon   +2 more
doaj   +1 more source

Assessing the Feasibility of Employing a Combination of a Bacteriophage-Derived Endolysin and Spore Germinants to Treat Relapsing Clostridioides difficile Infection

Microorganisms, 2023
Clostridioides difficile is a Gram-positive, anaerobic, spore-forming bacillus and is a major cause of healthcare-associated infections. Whereas the vegetative form of the pathogen is susceptible to treatment with antibiotics, its ability to persist in ...
Khalid Alyahya, Les Baillie
doaj   +1 more source

Porcine Recombinant NK-Lysin Inhibits the Growth and Metastasis of Murine Hepatocellular Carcinoma In Vivo

Molecules
Porcine recombinant NK-lysin (prNK-lysin) has been shown to inhibit the proliferation and metastasis of hepatocellular carcinoma (HCC) cells in vitro. However, its effects on the proliferation and metastasis of HCC cells in vivo remain unclear.
Kuohai Fan, Zhiwei Feng, Dahai Zhao, Xiaozhong Zheng, Wei Yin, Na Sun, Panpan Sun, Hongquan Li   +7 more
doaj   +1 more source