Results 11 to 20 of about 37,615 (246)

Identification of cell wall binding domains and repeats in Streptococcus pneumoniae phage endolysins: A molecular and diversity analysis [PDF]

Biochemistry and Biophysics Reports
Streptococcus pneumoniae (pneumococcus) is a multidrug-resistant pathogen associated with pneumonia, otitis media, meningitis and other severe complications that are currently a global threat to human health.
Tahsin Khan, Shakhinur Islam Mondal, Araf Mahmud, Daniyal Karim, Lorraine A. Draper, Colin Hill, Abul Kalam Azad, Arzuba Akter   +7 more
doaj   +2 more sources

Identification and analysis of the crucial holin domain and sites and the bactericidal activity of a holin–endolysin lysis cassette from phage PZL-Ah152 against Aeromonas hydrophila [PDF]

Journal of Virology
With the increasing prevalence of antibiotic-resistant bacteria, phage therapy has garnered significant attention. Holin and lysin play essential roles in the phage-induced lysis of bacteria. This study investigated the functions of the holin protein Hol
Chao Feng, Yan Cheng, Shuang Liang, Ruiqi Liang, Jiahao Yu, Shun Wang, Hui Guo, Xiaofeng Shan, Dongxing Zhang, Aidong Qian, Wuwen Sun, Lei Zhang   +11 more
doaj   +2 more sources

Novel delivery systems for phages and lysins in the topical management of wound infections: a narrative review [PDF]

Frontiers in Microbiology
Currently, multidrug-resistant (MDR) bacterial wound infections (WIs) are an extremely challenging clinical problem for physicians. Recently, compared to traditional single liquid delivery drugs, the study of five novel drug delivery systems (i.e ...
Pan Yang, Jing Li, Xiumei Ma, Nan Hu, Zhangyong Song, Bin Chen, Shizhu Li   +6 more
doaj   +2 more sources

Therapeutic efficacy of LysGH15 against necrotising pneumonia caused by Staphylococcus aureus in a rabbit model [PDF]

Frontiers in Veterinary Science
IntroductionStaphylococcus aureus (S. aureus) is one of the most important zoonotic pathogens and can be transmitted to humans through the meat diet routes, causing necrotising pneumonia.MethodsThis study investigated the therapeutic effect of ...
Bowei Zhang, Liran Song, Yongran Wang, Meimei Zhang, Chong Chen, Hui Ning, Li Wang, Cao Qiu, Xinwu Wang, Changjiang Sun, Xin Feng, Wenyu Han, Wenyu Han, Bin Wang, Yalu Ji, Jingmin Gu, Jingmin Gu   +16 more
doaj   +2 more sources

Characterization and Functional Evaluation of NK-lysin from Clownfish (Amphiprion ocellaris)

Fishes, 2023
In previous studies, natural killer lysin (NK-lysin) emerged as a crucial antimicrobial peptide (AMP) discharged by NK cells and CTLs. The sequence of NK-lysin was cloned and discovered in some fishes, but its function remains unclear.
Dapeng Yu, Haohang Zhao, Yiming Wen, Tao Li, Hongli Xia, Zhiwen Wang, Zhen Gan, Liqun Xia, Jianlin Chen, Yishan Lu   +9 more
doaj   +1 more source

Bacteriophage lysin mediates the binding of streptococcus mitis to human platelets through interaction with fibrinogen. [PDF]

PLoS Pathogens, 2010
The binding of bacteria to human platelets is a likely central mechanism in the pathogenesis of infective endocarditis. We have previously found that platelet binding by Streptococcus mitis SF100 is mediated by surface components encoded by a lysogenic ...
Ho Seong Seo, Yan Q Xiong, Jennifer Mitchell, Ravin Seepersaud, Arnold S Bayer, Paul M Sullam   +5 more
doaj   +1 more source

Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni. [PDF]

PLoS ONE, 2017
Bovine NK-lysins, which are functionally and structurally similar to human granulysin and porcine NK-lysin, are predominantly found in the granules of cytotoxic T-lymphocytes and NK-cells.
Rohana P Dassanayake, Shollie M Falkenberg, Robert E Briggs, Fred M Tatum, Randy E Sacco   +4 more
doaj   +1 more source

Distinct mode of action of a highly stable, engineered phage lysin killing Gram-negative bacteria

Microbiology Spectrum, 2023
Therapeutic options to treat bacterial infections caused by Gram-negative pathogens are limited due to the spread of multidrug resistance. Protein engineering of phage-derived lysins can play a key role in the search for new antimicrobial compounds ...
Hans Gerstmans, Lisa Duyvejonck, Roberto Vázquez, Ines Staes, Jimmy Borloo, Karim Abdelkader, Jeroen Leroy, Emma Cremelie, Diana Gutiérrez, Héctor Tamés-Caunedo, Patricia Ruas-Madiedo, Ana Rodríguez, Abram Aertsen, Jeroen Lammertyn, Rob Lavigne, Yves Briers   +15 more
doaj   +1 more source

Cluster J Mycobacteriophages: Intron Splicing in Capsid and Tail Genes [PDF]

, 2013
Bacteriophages isolated on Mycobacterium smegmatis mc2155 represent many distinct genomes sharing little or no DNA sequence similarity. The genomes are architecturally mosaic and are replete with genes of unknown function.
Best, AA, Broussard, GW, Connerly, PL, Conway, JF, Dedrick, RM, Hatfull, GF, Hendrix, RW, Jacobs-Sera, D, Kremer, TA, Offner, S, Ogiefo, AH, Pizzorno, MC, Pope, WH, Rockenbach, K, Russell, DA, Stowe, EL, Stukey, J, Thibault, SA   +17 more
core   +8 more sources

Lysine Ethylation by Histone Lysine Methyltransferases [PDF]

ChemBioChem, 2019
AbstractBiomedicinally important histone lysine methyltransferases (KMTs) catalyze the transfer of a methyl group from S‐adenosylmethionine (AdoMet) cosubstrate to lysine residues in histones and other proteins. Herein, experimental and computational investigations on human KMT‐catalyzed ethylation of histone peptides by using S‐adenosylethionine ...
Abbas H. K. Al Temimi, Michael Martin, Qingxi Meng, Danny C. Lenstra, Ping Qian, Hong Guo, Elmar Weinhold, Jasmin Mecinović   +7 more
openaire   +4 more sources