Results 91 to 100 of about 830,882 (287)

LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice [PDF]

, 2015
Mammalian oocytes are arrested at prophase I until puberty when hormonal signals induce the resumption of meiosis I and progression to meiosis II.
Chen, T, Kerenyi, MA, Kim, J, Lin, K, Lu, Y, Orkin, SH, Shen, J, Singh, AK, Takata, Y   +8 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A Robust, Enzyme-Free Glucose Sensor Based on Lysine-Assisted CuO Nanostructures

Sensors, 2016
The production of a nanomaterial with enhanced and desirable electrocatalytic properties is of prime importance, and the commercialization of devices containing these materials is a challenging task.
Qurrat-ul-Ain Baloach, Aneela Tahira, Arfana Begum Mallah, Muhammad Ishaq Abro, Siraj Uddin, Magnus Willander, Zafar Hussain Ibupoto   +6 more
doaj   +1 more source

Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation. [PDF]

, 2019
Molecular tweezers (MTs) are supramolecular host molecules equipped with two aromatic pincers linked together by a spacer (Gakh, 2018). They are endowed with fascinating properties originating from their ability to hold guests between their aromatic ...
Bitan, Gal, Hadrovic, Inesa, Klärner, Frank-Gerrit, Rebmann, Philipp, Schrader, Thomas   +4 more
core  

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Dietary management for pyridoxine‐dependent epilepsy due to α‐aminoadipic semialdehyde dehydrogenase deficiency, a follow‐on from the international consortium guidelines

JIMD Reports
Pyridoxine‐dependent epilepsy (PDE‐ALDH7A1) is a neurometabolic disorder in the lysine metabolism pathway. In 2014 and 2021, the International PDE consortium published consensus guidelines about diagnosis and management.
Marjorie Dixon, Chloe Millington, Laurie Bernstein, Curtis R. Coughlin II, Morgan Drumm, Sommer Gaughan, Clara D. M. vanKarnebeek, Annemiek M. J. vanWegberg   +7 more
doaj   +1 more source

Evaluating the Response of Cobb MV × Cobb 500 Broilers to Varying Amino Acid Density Regimens for a Small Bird Program

Journal of Applied Poultry Research, 2019
SUMMARY: Primary breeder companies are continuously striving to improve existing commercial broiler crosses to increase performance and reduce cost.
R.A. Hirai, L. Mejia, C. Coto, J. Caldas, C.D. McDaniel, K.G.S. Wamsley   +5 more
doaj   +1 more source

Ocean acidification affects marine chemical communication by changing structure and function of peptide signalling molecules [PDF]

, 2016
Ocean acidification is a global challenge that faces marine organisms in the near future with a predicted rapid drop in pH of up to 0.4 units by the end of this century.
Adamo, Bode, Bopp, Briffa, Brown, Browne, Clements, Compton, Crothers, Darnell, Decho, Dodd, Fabry, Forward, Grimme, Grimme, Halgren, Hall-Spencer, Hardege, Hardege, Hay, Hayden, Haye, Hehre, Henry, Hunter, Jensen, Jensen, Jensen, Kim, Klamt, Kratt, Kutzelnigg, Leduc, Lemly, Lide, Lodewyk, McDonald, McNeil, Munday, Munday, Neese, Neese, Nilsson, O'Boyle, Perdew, Pettis, Piotto, Po, Pörtner, R Core Team, Reinsel, Reisert, Rittschof, Rittschof, Rittschof, Rittschof, Sklenář, Steiger, Tegtmeyer, Tierney, Vries, Weigend, Wishart, Wittmann, Wyatt, Wyatt, Wyatt, Zimmer, Zimmer-Faust   +69 more
core   +1 more source