Results 101 to 110 of about 787,190 (346)
Journal of Agriculture and Rural Development in the Tropics and Subtropics, 2007 Mungbean or green gram (Vigna radiata L.) is an important component of rice-based cropping systems in Myanmar, where grain yields of around 800 kg ha^(-1) are much below its yield potential of 3000 kg ha^(-1).
M. Kywe, Andreas Buerkert, M. R. Finckh
doaj
Genetic incorporation of D-Lysine into diketoreductase in Escherichia coli cells [PDF]
, 2012 D-Lysine has been genetically introduced into diketoreductase in E. coli cells by utilization of an orthogonal Ph tRNA /Lysyl-tRNA synthetase pair.
Xin Yang +4 more
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Sirt5 Is an NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
Science, 2011 Biological functions of sirtuins may involve lysine desuccinylase and demalonylase activities. Silent information regulator 2 (Sir2) proteins (sirtuins) are nicotinamide adenine dinucleotide–dependent deacetylases that regulate important biological ...
Jintang Du +16 more
semanticscholar +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Global profiling of lysine reactivity and ligandability in the human proteome
Nature Chemistry, 2017 Nucleophilic amino acids make important contributions to protein function, including performing key roles in catalysis and serving as sites for post-translational modification.
S. Hacker +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Effect of dietary lysine on hepatic lysine catabolism in broilers ,
Poultry Science, 2013 Lysine is frequently a first- or second-limiting amino acid in poultry diets. Improving the efficiency of lysine use for protein synthesis would effectively lower the lysine requirement and decrease feed costs. Understanding how lysine is degraded and how the degradation is regulated would identify potential molecular targets for interventions to ...
A S, Kiess +4 more
openaire +2 more sources