Results 111 to 120 of about 787,190 (346)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Efeito comparativo entre clonixinato de lisina e paracetamol no controle da dor pós-exodontia

Revista Dor
JUSTIFICATIVA E OBJETIVOS: A exodontia é praticada desde os primórdios da humanidade como forma de resolver cirurgicamente os problemas dentários. Porém, como todo procedimento cirúrgico, ela promove um processo inflamatório reacional que se apresenta ...
Klinger de Souza Amorim, Lucas Celestino Guerzet Ayres, Rafael Soares da Cunha, Liane Maciel de Almeida Souza, Mônica Silveira Paixao, Francisco Groppo   +5 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Bioavailability of lysine from a liquid lysine source in chicks

Poultry Science, 1999
Two experiments were conducted to assess the bioavailability of lysine from a liquid lysine product (LLP; 60% lysine) relative to crystalline L-lysine.HCl. In the first experiment, four groups of five chicks were fed a lysine-deficient basal diet containing corn, soybean meal, and feather meal or the basal diet supplemented with 0.1 or 0.2% lysine from
J L, Emmert, M W, Douglas, S D, Boling, C M, Parsons, D H, Baker   +4 more
openaire   +2 more sources

Lysine acetylation in obesity, diabetes and metabolic disease

, 2011
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) mediate acetylation and deacetylation of histone proteins and transcription factors.
Fairlie, David P., Lindsay Brown, Brown, Lindsay, Abishek Iyer, Iyer, Abishek, David P Fairlie   +5 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Chemical and Biochemical Perspectives of Protein Lysine Methylation

Chemical Reviews, 2018
Protein lysine methylation is a distinct posttranslational modification that causes minimal changes in the size and electrostatic status of lysine residues.
M. Luo
semanticscholar   +1 more source

Bladder carcinogenesis in rats subjected to ureterosigmoidostomy and treated with L-lysine

, 2016
Objective: to evaluate the effect of L-lysine in the bladder and intestinal epithelia in rats submitted to vesicosigmoidostomy. Methods: we divided forty Wistar rats into four groups: group I - control group (Sham); group II - submitted to ...
André Vinicius Vieira Maciel (12720270), Antonio Lucas Oliveira Correia (12720261), João Paulo Ferreira Coelho (12720264), Francisco Vagnaldo Fechine Jamacaru (6426542), Bianca Lopes Cunha (12720267), Alessandra Marques dos Santos (12720258), Conceição Aparecida Dornelas (6426545), Camila de Carvalho Juanes (6426530)   +7 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. [PDF]

, 2012
Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires γH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me). Several histone methyltransferases have been
Guan, Yinghua, Rajendran, Anbazhagan, Jagesh V. Shah (116400), Anyong Xie (116396), Gunnar Schotta (116394), Anbazhagan Rajendran (116388), Yinghua Guan (116385), Anyong Xie, Yinghua Guan, Ralph Scully, Hartlerode, Andrea J., Andrea J Hartlerode, Anbazhagan Rajendran, Gunnar Schotta, Andrea J. Hartlerode, Jagesh V. Shah, Jagesh V Shah, Andrea J. Hartlerode (116383), Ralph Scully (116402), Xie, Anyong, Shah, Jagesh, Ura, Kiyoe, Kiyoe Ura (116391), Scully, Ralph, Kiyoe Ura, Schotta, Gunnar, Shah, Jagesh V., Shah Jagesh V., Hartlerode Andrea J., Schotta Gunnar, Ura Kiyoe, Guan Yinghua, Xie Anyong, Rajendran Anbazhagan, Scully Ralph   +34 more
core   +2 more sources