Results 71 to 80 of about 933,247 (382)
Regulation of NF-κB activity through lysine monomethylation of p65 [PDF]
, 2009 NF-κB is a key activator of inflammatory and immune responses with important pathological roles in cancer, heart disease, and autoimmune diseases. Transcriptional activity of NF-κB is regulated by different posttranslational modifications.
Baltimore, David, Ea, Chee-Kwee
core +3 more sources
Chemo- and Regioselective Lysine Modification on Native Proteins
Journal of the American Chemical Society, 2018 Site-selective chemical conjugation of synthetic molecules to proteins expands their functional and therapeutic capacity. Current protein modification methods, based on synthetic and biochemical technologies, can achieve site selectivity, but these ...
M. Matos +13 more
semanticscholar +1 more source
Effect of dietary lysine on hepatic lysine catabolism in broilers ,
Poultry Science, 2013 Lysine is frequently a first- or second-limiting amino acid in poultry diets. Improving the efficiency of lysine use for protein synthesis would effectively lower the lysine requirement and decrease feed costs. Understanding how lysine is degraded and how the degradation is regulated would identify potential molecular targets for interventions to ...
Aaron S. Kiess +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Dietary lysine requirement of adult lambari ( Astyanax altiparanae ) (Garutti and Britski, 2000)
Revista Brasileira de Zootecnia, 2018 A 90-day feeding trial was conducted to estimate the dietary lysine requirement of adult lambari ( Astyanax altiparanae ), based on growth performance, whole-body composition, muscle development, and aspartate aminotransferase (AST) and alanine ...
Daniel Abreu Vasconcelos Campelo +4 more
doaj +1 more source
Alpha-aminoadipic acid: A product of lysine metabolism [PDF]
, 1948 As part of a study of protein and peptide metabolism lysine was synthesized with C14 in the ε position and resolved into the L and D isomers. 10 mg. of labeled lysine dihydrochloride (either L- or D-) and 0.66 gm.
Borsook, Henry +4 more
core
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
Identification and characterization of an irreversible inhibitor of CDK2 [PDF]
, 2015 Irreversible inhibitors that modify cysteine or lysine residues within a protein kinase ATP binding site offer, through their distinctive mode of action, an alternative to ATP-competitive agents.
Anscombe, Elizabeth +16 more
core +1 more source
Cellular functions and molecular mechanisms of non-lysine ubiquitination
Open Biology, 2019 Protein ubiquitination is of great cellular importance through its central role in processes such as degradation, DNA repair, endocytosis and inflammation.
A. J. McClellan +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley +1 more source