Results 61 to 70 of about 787,190 (346)
Histone lysine methyltransferases in biology and disease
Nature Structural & Molecular Biology, 2019 The precise temporal and spatial coordination of histone lysine methylation dynamics across the epigenome regulates virtually all DNA-templated processes.
Dylan Husmann, O. Gozani
semanticscholar +1 more source
LSD1: more than demethylation of histone lysine residues
Experimental and Molecular Medicine, 2020 Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified nuclear protein with histone demethylase activity. In particular, it plays a special role in the epigenetic regulation of gene expression, as it removes methyl ...
B. Perillo +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Early lysine deficiency in young broiler chicks
Animal, 2007 The carry-over effect of a pre-starter diet (0 to 3 days of age) deficient in lysine on subsequent growth and body composition (3 to 10 days) was examined in two experiments on male broiler chicks raised in cages.
D. Bastianelli +6 more
doaj +1 more source
Animals, 2021 The purpose was to assess the effect of exchanging crude protein (CP) of soybean meal (SBM) with red clover silage (RCS) in total mixed rations (TMR) on ruminal degradation and intestinal digestibility (ID) of essential amino acids (EAA).
Edwin Westreicher-Kristen +6 more
doaj +1 more source
DNAzymes for Amine and Peptide Lysine Acylation [PDF]
, 2020 DNAzymes were previously identified by in vitro selection for a variety of chemical reactions, including several biologically relevant peptide modifications. However, finding DNAzymes for peptide lysine acylation is a substantial challenge.
Jack, Przybyla +6 more
core +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
The histone H3 lysine 36 methyltransferase HypB facilitates embryonic stem cell differentiation [PDF]
, 2007 Histone H3 lysine 36 (H3K36) methylation was identified as a conserved modification from yeast to human. In yeast, biochemical characterization of the SET2 protein and genome wide mapping of H3K36me2 and K36me3 indicate that H3K36 methylation functions ...
Wang, Tianke
core +1 more source
, 2023 The covalent inhibition of a target protein has gained widespread attention in the field of drug discovery. Most of the current covalent drugs utilize the high reactivity of cysteines toward modest electrophiles.
Kenji Higashiguchi (1277598) +5 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source