Results 51 to 60 of about 787,190 (346)

The immunogenicity of pMAA-lysine-BSA in the absence of adjuvant.

, 2017
C57BL/6 mice were injected i.p. with pMAA-lysine-BSA or BSA in the absence of adjuvant. The antibody titers of IgG (A) and IgM (B) against pMAA-lysine were detected using pMAA-6ACA-KLH-coated plates. The anti-MAA antibody titers were clearly increased in
Avram Gold (676580), Monte S. Willis (464831), Takasumi Shimomoto (3769555), Chunguang Wang (115065), Jun Nakamura (12339), Sohvi Hörkkö (173088), Zhenfa Zhang (134514), Scott J. Bultman (133418), Darcy W. Holley (3769558), Leonard B. Collins (2311588), Xianwen Yi (1918327), Xu Tian (179192), Koji Uchida (433258)   +12 more
core   +1 more source

New cationic nanovesicular systems containing lysine-based surfactants for topical administration: Toxicity assessment using representative skin cell lines [PDF]

, 2013
Many strategies for treating diseases require the delivery of drugs into the cell cytoplasm following internalization within endosomal vesicles. Thus, compounds triggered by low pH to disrupt membranes and release endosomal contents into the cytosol are ...
Vinardell, M. Pilar, Morán, María del Carmen, Vinardell Martínez-Hidalgo, Ma. Pilar, Mitjans, Montserrat, Mitjans Arnal, Montserrat, Morán Badenas, María del Carmen, Pérez, Lourdes, Martínez Ocaña, Verónica, Nogueira, Daniele R., Nogueira, Daniele Rubert, Pérez Muñoz, Lourdes, Martínez, Verónica Laura   +11 more
core   +1 more source

Lysine-Dependent Entropy Effects in the B. subtilis Lysine Riboswitch: Insights from Single-Molecule Thermodynamic Studies

, 2021
Riboswitches play an important role in RNA-based sensing/gene regulation control for many bacteria. In particular, the accessibility of multiple conformational states at physiological temperatures allows riboswitches to selectively bind a cognate ligand ...
Andrea Marton Menendez (11879796), Andrea Marton Menendez, David J. Nesbitt, David J. Nesbitt (1315116)   +3 more
core   +1 more source

Effects of rumen-protected lysine on antler growth performance, fecal bacterial community, and blood gene expression in sika deer

Frontiers in Veterinary Science
IntroductionVelvet antler is an important product of sika deer (Cervus nippon), and its growth is closely related to dietary amino acid supplementation.
Bo Yang, Yuhang Zhu, Yongxiang Li, Yating Gao, Huazhe Si, Zhipeng Li, Zhipeng Li, Zhipeng Li, Zhipeng Li   +8 more
doaj   +1 more source

The Limiting Sequence and Appropriate Amino Acid Ratio of Lysine, Methionine, and Threonine for Seven- to Nine-Month-Old Holstein Heifers Fed Corn–Soybean M-Based Diet

Animals, 2019
An “Amino acid (AA) partial deletion method” was used in this experiment to study the limiting sequences and appropriate ratio of lysine (Lys), methionine (Met), and threonine (Thr) in the diets of 7- to 9-month-old Holstein heifers.
Yuan Li, Yanliang Bi, Qiyu Diao, Minyu Piao, Bing Wang, Fanlin Kong, Fengming Hu, Mengqi Tang, Yu Sun, Yan Tu   +9 more
doaj   +1 more source

HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription

Nature Communications
Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. However, the regulatory mechanism and functional consequence of Kla remain to be explored.
Ziping Niu, Chen Chen, Siyu Wang, Congcong Lu, Zhiyue Wu, Aiyuan Wang, Jing Mo, Jianji Zhang, Yanpu Han, Ye Yuan, Yin-Gao Zhang, Yong Zang, Chaoran He, Xue Bai, Shanshan Tian, Gui-Jin Zhai, Xudong Wu, Kai Zhang   +17 more
semanticscholar   +1 more source

Non-Enzymatic Lysine Lactoylation of Glycolytic Enzymes

Cell Chemical Biology, 2019
Summary Post-translational modifications (PTMs) regulate enzyme structure and function to expand the functional proteome. Many of these PTMs are derived from cellular metabolites and serve as feedback and feed-forward mechanisms of regulation.
Dominique O. Gaffney, E. Jennings, C. Anderson, John O. Marentette, Tao-Da Shi, Anne-Mette Schou Oxvig, Matthew D. Streeter, M. Johannsen, D. Spiegel, E. Chapman, James R. Roede, J. Galligan   +11 more
semanticscholar   +1 more source

Co-Amorphous Andrographolide–Lysine with Unexpectedly Enhanced Solubility

Crystals
Andrographolide (ADG) is a typical poorly water-soluble drug, and a co-amorphous strategy was used here to improve its aqueous solubility. Co-amorphous systems of ADG and amino acids with a 1:1 molar ratio were screened via the neat ball milling method ...
Haifeng Luo, Yuchen Zheng, Shizhao Ren, Wangchuan Xiao, Rongrong Xue, Wei Han, Fenghua Chen   +6 more
doaj   +1 more source

Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis

Nature Chemical Biology
Lysine l-lactylation (Kl-la) is a novel protein posttranslational modification (PTM) driven by l-lactate. This PTM has three isomers: Kl-la, N-ε-(carboxyethyl)-lysine (Kce) and d-lactyl-lysine (Kd-la), which are often confused in the context of the ...
Di Zhang, Jinjun Gao, Zhi-Jun Zhu, Qianying Mao, Zhi-Qiang Xu, Pankaj K. Singh, C. Rimayi, Carlos Moreno-Yruela, Shuling Xu, Gongyu Li, Yi-Cheng Sin, Yue Chen, C. A. Olsen, Nathaniel W. Snyder, Lun-Zhi Dai, Ling-Jun Li, Yingming Zhao   +16 more
semanticscholar   +1 more source

Lysine-Targeting Reversible Covalent Inhibitors with Long Residence Time

, 2022
We report a new reversible lysine conjugation that features a novel diazaborine product and much slowed dissociation kinetics in comparison to the previously known iminoboronate chemistry.
Wenjian Wang, Yuhan Lyu, Yuhan Lyu (11961139), Jianmin Gao, Fredrik Haeffner (1310373), Rahi M. Reja (4117852), Wenjian Wang (314196), Jianmin Gao (553214), Rahi M. Reja, Fredrik Haeffner   +9 more
core   +1 more source