Results 41 to 50 of about 582,369 (357)

Arginine and Lysine Promote Skeletal Muscle Hypertrophy by Regulating the mTOR Signaling Pathway in Bovine Myocytes

Meat and Muscle Biology, 2023
The objective of this study was to assess the effects of additional arginine (ARG) and lysine (LYS) on the regulatory factors associated with myogenic differentiation of bovine satellite cells and hypertrophy of myotubes.
Jongkyoo Kim, Won Seob Kim
doaj   +2 more sources

Targeting AASS alleviates neurotoxicity and improves mitochondrial function in astrocyte models for pyridoxine-dependent epilepsy

Molecular Therapy: Nucleic Acids
Pyridoxine-dependent epilepsy (PDE) is a rare neurometabolic disorder of lysine catabolism caused by bi-allelic variants in ALDH7A1. This enzyme deficiency leads to accumulation of neurotoxic metabolites, pyridoxal-phosphate inactivation, and ...
Imke M.E. Schuurmans, Udo Engelke, Muna Abedrabbo, Sofía Puvogel, Rachel Mijdam, Gijs-Jan Scholten, Sara B. van Katwijk, Astrid Oudakker, Hilal H. Al-Shekaili, Dirk J. Lefeber, Blair R. Leavitt, Clara D.M. van Karnebeek, Nael Nadif Kasri, Alejandro Garanto   +13 more
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Gustatory sensitivity to amino acids in bumblebee mouthparts

Royal Society Open Science
Bees rely on amino acids from nectar and pollen for essential physiological functions. While nectar typically contains low (less than 1 mM) amino acid concentrations, levels in pollen are higher but variable (10–200 mM).
Sergio Rossoni, Rachel H. Parkinson, Jeremy E. Niven, Elizabeth Nicholls   +3 more
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Development of a Hyperosmotic Stress Inducible Gene Expression System by Engineering the MtrA/MtrB-Dependent NCgl1418 Promoter in Corynebacterium glutamicum

Frontiers in Microbiology, 2021
Corynebacterium glutamicum is an important workhorse for industrial production of diversiform bioproducts. Precise regulation of gene expression is crucial for metabolic balance and enhancing production of target molecules.
Jingwen Huang, Jingwen Huang, Jiuzhou Chen, Yu Wang, Tuo Shi, Xiaomeng Ni, Wei Pu, Jiao Liu, Yingyu Zhou, Yingyu Zhou, Ningyun Cai, Shuangyan Han, Ping Zheng, Jibin Sun, Jibin Sun   +14 more
doaj   +1 more source

Histone lysine methyltransferases in biology and disease

Nature Structural & Molecular Biology, 2019
The precise temporal and spatial coordination of histone lysine methylation dynamics across the epigenome regulates virtually all DNA-templated processes.
Dylan Husmann, O. Gozani
semanticscholar   +1 more source

Effects of rumen-protected lysine on antler growth performance, fecal bacterial community, and blood gene expression in sika deer

Frontiers in Veterinary Science
IntroductionVelvet antler is an important product of sika deer (Cervus nippon), and its growth is closely related to dietary amino acid supplementation.
Bo Yang, Yuhang Zhu, Yongxiang Li, Yating Gao, Huazhe Si, Zhipeng Li, Zhipeng Li, Zhipeng Li, Zhipeng Li   +8 more
doaj   +1 more source

The Limiting Sequence and Appropriate Amino Acid Ratio of Lysine, Methionine, and Threonine for Seven- to Nine-Month-Old Holstein Heifers Fed Corn–Soybean M-Based Diet

Animals, 2019
An “Amino acid (AA) partial deletion method” was used in this experiment to study the limiting sequences and appropriate ratio of lysine (Lys), methionine (Met), and threonine (Thr) in the diets of 7- to 9-month-old Holstein heifers.
Yuan Li, Yanliang Bi, Qiyu Diao, Minyu Piao, Bing Wang, Fanlin Kong, Fengming Hu, Mengqi Tang, Yu Sun, Yan Tu   +9 more
doaj   +1 more source

HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription

Nature Communications
Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. However, the regulatory mechanism and functional consequence of Kla remain to be explored.
Ziping Niu, Chen Chen, Siyu Wang, Congcong Lu, Zhiyue Wu, Aiyuan Wang, Jing Mo, Jianji Zhang, Yanpu Han, Ye Yuan, Yingao Zhang, Yong Zang, Chaoran He, Xue Bai, Shanshan Tian, Guijin Zhai, Xudong Wu, Kai Zhang   +17 more
semanticscholar   +1 more source

LSD1: more than demethylation of histone lysine residues

Experimental and Molecular Medicine, 2020
Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified nuclear protein with histone demethylase activity. In particular, it plays a special role in the epigenetic regulation of gene expression, as it removes methyl ...
B. Perillo, A. Tramontano, A. Pezone, A. Migliaccio   +3 more
semanticscholar   +1 more source

Co-Amorphous Andrographolide–Lysine with Unexpectedly Enhanced Solubility

Crystals
Andrographolide (ADG) is a typical poorly water-soluble drug, and a co-amorphous strategy was used here to improve its aqueous solubility. Co-amorphous systems of ADG and amino acids with a 1:1 molar ratio were screened via the neat ball milling method ...
Haifeng Luo, Yuchen Zheng, Shizhao Ren, Wangchuan Xiao, Rongrong Xue, Wei Han, Fenghua Chen   +6 more
doaj   +1 more source