Results 101 to 110 of about 438,961 (309)

Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization

Advanced Materials, EarlyView.
A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab, Jack F. Murphy, Michael Bartolf‐Kopp, Jenny C‐C Hsin, Alice Chernaik, Frank McCaughan, Yan Yan Shery Huang, Tomasz Jungst, Jürgen Groll   +8 more
wiley   +1 more source

Lysine Acetylation of CREBH Regulates Fasting-Induced Hepatic Lipid Metabolism

, 2015
Cyclic AMP-responsive element-binding protein 3-like 3, hepatocyte specific (CREBH), is a hepatic transcription factor that functions as a key regulator of energy homeostasis.
Mendez, Roberto, Kim, Hyunbae, Zhang, Kezhong, Chen, Xuequn, Fang, Deyu   +4 more
core   +1 more source

Cfp1 is required for gene expression dependent H3K4me3 and H3K9 acetylation in embryonic stem cells [PDF]

, 2014
BackgroundTrimethylation of histone H3 lysine 4 (H3K4me3) accumulates at promoters in a gene activity dependent manner. The Set1 complex is responsible for most H3K4me3 in somatic cells and contains the conserved subunit Cfp1, which is implicated in ...
Webb, Shaun, Clouaire, Thomas, Bird, Adrian; id_orcid   +2 more
core   +1 more source

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Modification‐Selective Inhibition of Succinate Dehydrogenase a Enables Tumor‐Restricted Mitochondrial Modulation

Advanced Science, EarlyView.
This work identifies acetylation‐dependent SDHA homeostasis as a determinant of tumor‐specific metabolic vulnerability. Guided by this mechanism, a modification‐selective inhibitor, ZPI‐3, selectively targets non‐acetylated SDHA, achieving tumor‐restricted SDH inhibition and effective bladder cancer control. Differential responses in clinical specimens
Kaikai Xu, Lulu Kong, Kebin Ye, Xinlu Bao, Haowen Liu, Ning Wang, Yongming Deng, Wei Wang, Shaohua Wei, Lin Zhou   +9 more
wiley   +1 more source

Reversible Lysine Acetylation Regulates Activity of Human Glycine N-Acyltransferase-like 2 (hGLYATL2): Implications for Production of Glycine-conjugated Signaling Molecules [PDF]

, 2012
Background: Lysine acetylation is a major post-translational modification of proteins. Results: Human glycine N-acyltransferase-like 2 is regulated by acetylation/deacetylation of lysine 19.
Sucharski, Filip, Sipos, Laszlo, Waluk, Dominik P.,, Silberring, Jerzy, Hunt, Mary C., Waluk, Dominick P., Hunt, Mary   +6 more
core   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Involvement of protein lysine acetylation in mediating grape berry ripening

Scientia Horticulturae
Protein lysine acetylation is a dynamic post-translational modification crucial for regulating diverse biological processes in plants, yet its role in grape berry ripening remains largely unexplored. Here we investigate this role using the grape cultivar
Yandi Wu, Xi Li, Jingjing Li, Yanle Yang, Tianyu Zhou, Chonghuai Liu, Yonghui Zhang, Aizhong Liu   +7 more
doaj   +1 more source

N-terminal acetylation can stabilize proteins independent of their ubiquitination

Scientific Reports, 2023
The majority of proteins in mammalian cells are modified by covalent attachment of an acetyl-group to the N-terminus (Nt-acetylation). Paradoxically, Nt-acetylation has been suggested to inhibit as well as to promote substrate degradation.
Bert van de Kooij, Evert de Vries, Rogier W. Rooswinkel, George M. C. Janssen, Frédérique K. Kok, Peter A. van Veelen, Jannie Borst   +6 more
doaj   +1 more source

Site-Specific Reactivity of Nonenzymatic Lysine Acetylation

, 2016
Protein acetylation of lysine ε-amino groups is abundant in cells, particularly within mitochondria. The contribution of enzyme-catalyzed and nonenzymatic acetylation in mitochondria remains unresolved.
John M. Denu (585630), Michael J. Smallegan (1375140), Josue Baeza (313573)   +2 more
core   +1 more source