Results 121 to 130 of about 438,961 (309)
Bacterial protein acetylation: mechanisms, functions, and methods for study
Frontiers in Cellular and Infection MicrobiologyLysine acetylation is an evolutionarily conserved protein modification that changes protein functions and plays an essential role in many cellular processes, such as central metabolism, transcriptional regulation, chemotaxis, and pathogen virulence.
Jocelin Rizo +1 more
doaj +1 more source
Hat1-Dependent Lysine Acetylation Targets Diverse Cellular Functions
bioRxiv, 2019 Lysine acetylation has emerged as one of the most important post-translational modifications, regulating different biological processes. However, its regulation by lysine acetyltransferases is still unclear in most cases.
Paula A. Agudelo Garcia +2 more
semanticscholar +1 more source
The importance of acetylation of STAT3 (pdb:1BG1) and lysine acetylation equation.
, 2016 (A) Jak-STAT signaling pathway, including phosphorylation and acetylation. (B) The schematic diagram of HSE. An acetyl group (CH3CO-) from Ace-CoA replaces the hydrogen atom in the epsilon-amino group (-NH3+)(blue) of side chain (red) of lysine residue ...
Yanping Zhang (153797) +4 more
core +1 more source
Advanced Science, EarlyView.The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li +9 more
wiley +1 more source
Acetylome analysis of lysine acetylation in the plant pathogenic bacterium Brenneria nigrifluens
MicrobiologyOpen, 2020 Protein lysine acetylation, a dynamic and reversible posttranslational modification, plays a crucial role in several cellular processes, including cell cycle regulation, metabolism, enzymatic activities, and protein interactions. Brenneria nigrifluens is
Yong Li +4 more
doaj +1 more source
International Journal of Molecular Sciences, 2019 Heat stress (HS) is an important factor for the survival of the marine organism Apostichopus japonicus. Lysine acetylation is a pivotal post-translational modification that modulates diverse physiological processes including heat shock response (HSR). In
Dong-Xue Xu, Xuan Wang
semanticscholar +1 more source
Advanced Science, EarlyView.SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu +13 more
wiley +1 more source
PLoS ONE, 2016 Lysine acetylation is a major post-translational modification. It plays a vital role in numerous essential biological processes, such as gene expression and metabolism, and is related to some human diseases.
Qiqige Wuyun +4 more
doaj +1 more source
Advanced Science, EarlyView.We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka +10 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2018 Protein lysine acetylation is recognized as an important reversible post translational modification in all domains of life. While its primary roles appear to reside in metabolic processes, lysine acetylation has also been implicated in regulating ...
Carsten Jers +7 more
doaj +1 more source