Results 131 to 140 of about 438,961 (309)

Identification of lysine acetylation in GFAP.

, 2013
The LC-MS/MS data from the protein clusters potentially with different charges were subjected to phosphorylation and acetylation modification analysis. Lysine acetylation was identified on several GFAP peptides.
Junqiang Li (491954), Fernando Vieira (261320), Chaoxu Liu (491953), Kefeng Dou (174028), Neil W. Kowall (491956), Han-Pil Choi (422967), Zhou Fei (86766), Kazem Azadzoi (491955), Yun Yang (417125), Jing-Hua Yang (491957), Dong Liu (115204)   +10 more
core   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal‐to‐Nuclear Signaling and 3D Spatio‐Epigenomic Remodeling

Advanced Science, EarlyView.
Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng, Jaegeon Joo, Yu Meng Li, Cheng Ji Li, Ali Taghizadeh, Seung Jae Shin, Buuvee Bayarkhangai, Tae‐Woo Ha, Sak Lee, Jaewoo Chung, Bo‐Eun Yoon, Hye Sung Kim, Inkyung Jung, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +15 more
wiley   +1 more source

Comprehensive proteome analyses of lysine acetylation in tea leaves by sensing nitrogen nutrition

BMC Genomics, 2018
Nε-Acetylation of lysine residues, a frequently occurring post-translational modification, plays important functions in regulating physiology and metabolism.
Ju-Tang Jiang, Z. Gai, Yu Wang, K. Fan, Li-Tao Sun, Hui Wang, Zhao-Tang Ding   +6 more
semanticscholar   +1 more source

Lysine acetylation of major Chlamydia trachomatis antigens [PDF]

, 2016
Chlamydia trachomatis (Ct) is a human pathogen causing trachoma and infertility. We investigated acetylation at lysine residues of chlamydial antigenic proteins: major outer membrane protein (MOMP), 60kDa chaperonin (chlamydial Hsp60), elongation factor ...
Stein, Elisabeth, Aleksandra Inic-Kanada, Mihailović-Vesić, Jelena, Elisabeth Stein, Katarina Smiljanic, Mihailovic, Jelena, Jelena Mihailovic, Tanja Cirkovic Velickovic, Barisani-Asenbauer, T., Talin Barisani-Asenbauer, Barisani-Asenbauer, Talin, Smiljanić, Katarina, Ćirković Veličković, Tanja, Inić-Kanada, Aleksandra   +13 more
core   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Nε-lysine acetylation in the endoplasmic reticulum – a novel cellular mechanism that regulates proteostasis and autophagy

Journal of Cell Science, 2018
Protein post-translational modifications (PTMs) take many shapes, have many effects and are necessary for cellular homeostasis. One of these PTMs, Nε-lysine acetylation, was thought to occur only in the mitochondria, cytosol and nucleus, but this ...
Mark A. Farrugia, L. Puglielli
semanticscholar   +1 more source

Correction to Mapping of Lysine Methylation and Acetylation in Core Histones of Neurospora crassa

, 2016
Correction to Mapping of Lysine Methylation and Acetylation in Core Histones of Neurospora ...
Lei Xiong (334812), Eric U. Selker (50159), Keyur K. Adhvaryu (191569), Yinsheng Wang (8699)   +3 more
core   +1 more source

Regulation of bacterial physiology by lysine acetylation of proteins

New Biotechnology, 2014
Post-translational modification of proteins is a reversible mechanism of cellular adaptation to changing environmental conditions. In eukaryotes, the physiological relevance of N-ɛ-lysine protein acetylation is well demonstrated. In recent times, important roles in the regulation of metabolic processes in bacteria are being uncovered, adding complexity
Bernal, Vicente, Castaño-Cerezo, Sara, Gallego-Jara, Julia, Écija-Conesa, Ana, de Diego, Teresa, Iborra, José Luis, Cánovas, Manuel   +6 more
openaire   +4 more sources

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source