Results 131 to 140 of about 4,831 (203)

SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer [PDF]

, 2018
Peroxisomes account for ~35% of total H2O2 generation in mammalian tissues. Peroxisomal ACOX1 (acyl-CoA oxidase 1) is the first and rate-limiting enzyme in fatty acid β-oxidation and a major producer of H2O2 ACOX1 dysfunction is linked to peroxisomal ...
Chen, Lei‐Lei, Chen, Xiu‐Fei, Chen, Yu‐Jia, Cheng, Zhou‐Li, Duan, Kun‐Long, Gao, Chao, Guan, Kun‐Liang, Jin, Lei, Liu, Wei‐Ren, Shi, Ying‐Hong, Sun, Ren‐Qiang, Sun, Yi‐Ping, Tian, Meng‐Xin, Wang, Fang, Xiong, Yue, Yang, Yi, Ye, Dan, Yu, Hong‐Xiu, Zhang, Jin‐Ye, Zhang, Meng‐Li, Zhao, Yu‐Zheng, Zhou, Li‐Sha, Zhou, Wen‐Jie   +22 more
core   +1 more source

Quantitative proteome and lysine succinylome characterization of zinc chloride smoke-induced lung injury in mice

Heliyon
The inhalation of zinc chloride (ZnCl2) smoke is one of common resources of lung injury, potentially resulting in severe pulmonary complications and even mortality.
Rui Zhou, Zhiwei Tu, Daishi Chen, Wanmei Wang, Shuzi Liu, Linjun She, Zhan Li, Jihong Liu, Yabin Li, Yu Cui, Pan Pan, Fei Xie   +11 more
doaj   +1 more source

No wisdom in the crowd: genome annotation at the time of big data - current status and future prospects [PDF]

, 2018
Science and engineering rely on the accumulation and dissemination of knowledge to make discoveries and create new designs. Discovery-driven genome research rests on knowledge passed on via gene annotations.
Danchin, Antoine
core  

Mechanism and dynamics of acyl-CoA mediated protein lysine acylation in mitochondria [PDF]

, 2016
Mitochondrien repräsentieren zelluläre Organellen mit einem hohen Gehalt an acetylierten Proteinen, im Vergleich zu anderen zellulären Kompartimenten. Im Mitochondrium angesiedelte Lysin-Acetyltransferasen sind jedoch nicht bekannt. Hier zeigen wir, dass
Simic, Zeljko
core   +1 more source

Succinylome Profiling the Function and Distribution of Lysine Succinylation in Saccharopolyspora erythraea

Applied Biochemistry and Biotechnology
Abstract As a novel protein post-translational modification, lysine succinylation is widely involved in metabolism regulation. To describe succinylated lysine's physiological functions and distribution patterns in Saccharopolyspora erythraea, a large and global protein succinylome was identified in a hypersuccinylated strain E3ΔsucC, using high-
Xiang Ke, Xing Jiang, Muhammad Hammad Hussain, Xiwei tian, Ju Chu   +4 more
openaire   +2 more sources

Lysine Succinylation of VBS Contributes to Sclerotia Development and Aflatoxin Biosynthesis in Aspergillus flavus. [PDF]

Mol Cell Proteomics, 2023
Wang Y, Yang M, Ge F, Jiang B, Hu R, Zhou X, Yang Y, Liu M.   +7 more
europepmc   +1 more source

SUCLG1 deficiency-induced histone succinylation impairs oncogene expression in acute myeloid leukemia

Cell Reports
Summary: Mitochondria-driven histone lysine succinylation is emerging as a critical signaling system that links cellular metabolism to the pathogenesis of diseases, including cancer. Here, we report that a global increase in protein/histone succinylation
Mengqing Gao, Minhui Shi, Hao Ding, Lei Xu, Na Zhao, Li Wang, Shujuan Huang, Hui Jiang, Ekaterina Bourova-Flin, Jianqing Mi, Saadi Khochbin, Domenico Iuso, Xiaoyu Zhu   +12 more
doaj   +1 more source

pSuc-EDBAM: Predicting lysine succinylation sites in proteins based on ensemble dense blocks and an attention module. [PDF]

BMC Bioinformatics, 2022
Jia J, Wu G, Li M, Qiu W.
europepmc   +1 more source

Proteomic profiling of lysine acetylation and succinylation in Staphylococcus aureus

Clinical and Translational Medicine, 2022
Jingyan Xia, Jinliang Liu, Feng Xu, Hui Zhou   +3 more
openaire   +3 more sources

SIRT5-mediated desuccinylation of MTHFD2 enhances chemoresistance in breast cancer cells by reducing therapy-induced senescence

Communications Biology
Protein lysine succinylation is a crucial post-translational modification that regulates nearly all aspects of eukaryotic and prokaryotic cell, including gene transcription, cell metabolism and redox homeostasis. Among them, metabolic disorders caused by
Zhang Xianhong, Gao Yue, Zhang Yu, Zhang Yichen, Chen Yufei, Pei Xinke, Zhang Jinhui, Wang Yiqi, Du Yitian, Hao Shuailin, Ni Ting   +10 more
doaj   +1 more source