Results 91 to 100 of about 1,291,574 (308)

Stressed fibrin lysis [PDF]

Journal of Thrombosis and Haemostasis, 2011
See also Varju I, Sotonyi P, Machovich R, Szabo L, Tenekedjiev K, Silva MMCG, Longstaff C, Kolev K. Hindered dissolution of fibrin formed under mechanical stress. This issue, pp 979–86.
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Lytic and mechanical stability of clots composed of fibrin and blood vessel wall components. [PDF]

, 2013
Background Proteases expressed in atherosclerotic plaque lesions generate collagen fragments, release glycosaminoglycans (chondroitin sulfate [CS] and dermatan sulfate [DS]) and expose extracellular matrix (ECM) proteins (e.g.
Bóta, Attila, Kolev, K., Komorowicz, E., Longstaff, C., Machovich, R., Rottenberger, Z., Szabó, László, Varga, Zoltán   +7 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Diterpenoids from Azorella compacta (Umbelliferae) active on Trypanosoma cruzi

Memorias do Instituto Oswaldo Cruz, 2003
The anti-Trypanosoma cruzi activity of natural products isolated from Azorella compacta was evaluated, with particular emphasis on their effect against intracellular amastigotes. Five diterpenoids from A.
Araya Jorge E, Neira Iván, Silva Solange da, Mortara Renato A, Manque Patricio, Cordero Esteban, Sagua Hernán, Loyola Alberto, Bórquez Jorge, Morales Glauco, González Jorge   +10 more
doaj  

Experimental assessment of interactions between marine bacteria and model protists: from predator-prey relationships to bacterial-mediated lysis

Applied and Environmental Microbiology
Bacteria in aquatic environments are a principal food source for predatory protists. Whereas interactions between bacteria and protists are recognized to determine the pathogenesis and epidemiology of several human pathogens, few studies have ...
Diana Axelsson-Olsson, Nikolaj Gubonin, Stina Israelsson, Jarone Pinhassi   +3 more
doaj   +1 more source

True Love Is Requited: The Argument of Lysis 221d-222a [PDF]

, 2004
I defend the argument in Plato's Lysis that true love is requited. I state the argument, the main objections, and my replies.
Rudebusch, George
core  

The ColRS system is essential for the hunger response of glucose-growing Pseudomonas putida [PDF]

, 2011
Background The survival of bacteria largely depends on signaling systems that coordinate cell responses to environmental cues. Previous studies on the two-component ColRS signal system in Pseudomonas putida revealed a peculiar subpopulation ...
Marta Putrinš, Andres Ainelo, Heili Ilves, Rita Hõrak   +3 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Evolutionary comparison between viral lysis rate and latent period

, 2013
Marine viruses shape the structure of the microbial community. They are, thus, a key determinant of the most important biogeochemical cycles in the planet.
Bonachela, Juan A., Levin, Simon A.
core   +1 more source