Results 101 to 110 of about 43,690 (287)

Temperate phage-antibiotic synergy across antibiotic classes reveals new mechanism for preventing lysogeny

mBio
A recent demonstration of synergy between a temperate phage and the antibiotic ciprofloxacin suggested a scalable approach to exploiting temperate phages in therapy, termed temperate phage-antibiotic synergy, which specifically interacted with the lysis ...
Amany M. Al-Anany, Rabia Fatima, Gayatri Nair, Jordan T. Mayol, Alexander P. Hynes   +4 more
doaj   +1 more source

Facile one-pot synthesis of amoxicillin-coated gold nanoparticles and their antimicrobial activity [PDF]

, 2014
Nanomaterials have been the object of intense study due to promising applications in a number of different disciplines. In particular, medicine and biology have seen the potential of these novel materials with their nanoscale properties for use in ...
A Fleming, A Kumar, A Rai, B Duncan, CK Kim, D Pissuwan, E Boisselier, G Frens, H Gu, HC Neu, J Turkevich, JD Gibson, KB Holten, M Brust, M De, MC Daniel, MN Martin, P Ghosh, RA Sperling, V Sambhy   +19 more
core   +1 more source

Characterization of the dynamic microbiome evolution across thrips species

Insect Science, EarlyView.
Comprehensive survey of the microbiome in thrips. The dominant bacterial genera found in thrips include intracellular ones, such as Wolbachia and Spiroplasma, and extracellular ones, including Serratia, Pantoea, and Acinetobacter. We isolated and sequenced high‐quality genomes of two dominant symbionts, Pantoea dispersa and Serratia marcescens.
Xiaodi Hu, Zhaohui Shi, Yangwei Gao, Hanze Zheng, Lin Lin, Jian‐Ping Chen, Yong Chen, Chuan‐Xi Zhang, Yiyuan Li   +8 more
wiley   +1 more source

Human Group A Streptococci Virulence Genes in Bovine Group C Streptococci

Emerging Infectious Diseases, 2010
Phage-encoded virulence genes of group A streptococci were detected in 10 (55.6%) of 18 isolates of group C streptococci that had caused bovine mastitis.
Márcia G. Rato, Ricardo Bexiga, Sandro F. Nunes, Cristina L. Vilela, Ilda Santos-Sanches   +4 more
doaj   +1 more source

A forward genetic screen identifies host factors that influence the lysis-lysogeny decision in phage lambda [PDF]

, 2017
The lysis‐lysogeny decision made by bacteriophage lambda is one of the classic problems of molecular biology. Shortly after infecting a cell, the virus can either go down the lytic pathway and make more viruses, or go down the lysogenic pathway and ...
Bodner, K., Covert, M. W., Gross, C. A., Huang, K. C., Miguel, A., Quach, N. T., Silvis, M. R., Tanouchi, Y., Van Valen, D. A.   +8 more
core  

Functional and structural dissection of the tape measure protein of lactococcal phage TP901-1 [PDF]

, 2016
The tail tape measure protein (TMP) of tailed bacteriophages (also called phages) dictates the tail length and facilitates DNA transit to the cell cytoplasm during infection. Here, a thorough mutational analysis of the TMP from lactococcal phage TP901-1 (
Alqarni, Mona, Cambillau, Christian, Feyereisen, Marine, Mahony, Jennifer, Spinelli, Silvia, Stockdale, Stephen, van Sinderen, Douwe   +6 more
core   +5 more sources

Effect of the microbiome on pathogen susceptibility across four Drosophilidae species

Insect Science, EarlyView.
Four Drosophilidae species were used to investigate how variation in the host microbiome influences susceptibility to infection. Microbial composition and abundance differed among species and treatments. The effects of microbiome manipulation on host survival were both species‐ and pathogen‐specific.
Hongbo Sun, Ben Longdon, Ben Raymond
wiley   +1 more source

Phycocyanobilin biosynthesis in Galdieria sulphuraria requires isomerization of phycoerythrobilin synthesized by bilin reductases

The FEBS Journal, EarlyView.
The biosynthesis of bilins, tetrapyrroles essential for light harvesting and sensing, is performed by specific enzymes (FDBRs). In Galdieria sulphuraria, both phycobiliprotein types bind phycocyanobilin, despite lacking the canonical synthesizing gene PCYA. Instead, PEBA and PEBB are encoded, producing phycoerythrobilin, proposed to be later isomerized
Federica Frascogna, Nathan C. Rockwell, Jana Hartmann, Julie M. Mudler, Nicole Frankenberg‐Dinkel   +4 more
wiley   +1 more source

Exponential sensitivity of noise-driven switching in genetic networks [PDF]

, 2008
Cells are known to utilize biochemical noise to probabilistically switch between distinct gene expression states. We demonstrate that such noise-driven switching is dominated by tails of probability distributions and is therefore exponentially sensitive ...
Mehta, Pankaj, Mukhopadhyay, Ranjan, Wingreen, Ned S.   +2 more
core   +3 more sources

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source