Results 81 to 90 of about 24,890 (193)
Engineering Murine Cross‐Reactivity Into an Affibody to Human Death Receptor 5
Biotechnology and Bioengineering, Volume 123, Issue 7, Page 1783-1798, July 2026.ABSTRACT Interspecies cross‐reactive protein therapeutics that target conserved epitopes across species are critical for translational research. The present study showcases the engineering of an affibody molecule, originally discovered for binding to human death receptor 5 (hDR5) with 94 nM affinity, to simultaneously acquire cross‐reactivity to murine
Tse‐Han Kuo +3 more
wiley +1 more source
Mechanisms of Antiphage Defense in Prokaryotes
Антибиотики и ХимиотерапияThe globalization of the problem of the formation of bacterial strains poly- and pan-resistant to known antimicrobial drugs creates high risks in the healthcare sector.
А. D. Daudova +7 more
doaj +1 more source
Prevalence, Host Range, and Comparative Genomic Analysis of Temperate Ochrobactrum Phages
Frontiers in Microbiology, 2017 Ochrobactrum and Brucella are closely related bacteria that populate different habitats and differ in their pathogenic properties. Only little is known about mobile genetic elements in these genera which might be important for survival and virulence ...
Claudia Jäckel +5 more
doaj +1 more source
Engineered B7‐H3 Binding in Modular Gp2 Miniproteins
Biotechnology and Bioengineering, Volume 123, Issue 7, Page 1871-1881, July 2026.ABSTRACT B7‐H3, an important immune checkpoint modulator of T‐cell function, is a tumor vasculature biomarker and is overexpressed in a variety of cancers. Its expression is associated with tumor growth, metastasis, and poor clinical prognosis, which makes B7‐H3 an appealing target for diagnostics and therapeutics.
Abbigael Harthorn +5 more
wiley +1 more source
R17 Drives Heparan Sulfate Clearance via Endolysosomal Trafficking
Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.R17 is a viral protein that binds heparan sulfate glycosaminoglycans and traffics them to the lysosome, leading to their degradation in a manner that does not require the presence of the cation‐independent mannose‐6‐phosphatre receptor. In BxPC3 pancreatic cancer cells, this loss in heparan sulfate results in the reduction of cell migration.
Pranali Bedekar +7 more
wiley +1 more source
ChemistrySelect, Volume 11, Issue 25, 3 July 2026.A straightforward method to cleanly yield a novel diene from isopulegol was developed. The diene served as a precursor to various cycloadducts, which led to the identification of Michael acceptors as antimicrobial motifs. ABSTRACT Conjugated dienes are useful precursors to cascade reactions that undergo cycloadditions to access polycyclic compounds ...
Jose G. Urbiola +6 more
wiley +1 more source
Microbial Biotechnology, Volume 19, Issue 7, July 2026.The selective nature through which coumarin compounds produced by different species of plants target PQS signalling in Pseudomonas aeruginosa and select for distinct phenotypic responses in key pathogenic organisms adds to the growing evidence of their utility as natural virulence suppressors. ABSTRACT Cell‐to‐cell communication in microbial systems is
Dylan Boon +8 more
wiley +1 more source
Applied and Environmental MicrobiologyBacteriophages (phages), the dominant prokaryotic viruses that specifically target bacteria in the human gut microbiome, play a crucial role in maintaining intestinal balance, regulating bacterial populations, and preserving microbial diversity within ...
Song Zhang +5 more
doaj +1 more source
Bacterial resistance to temperate phage is influenced by the frequency of lysogenic establishment
iScienceSummary: Temperate phages can shape bacterial community dynamics and evolution through lytic and lysogenic life cycles. In response, bacteria that resist phage infection can emerge.
Hiba Baaziz +3 more
doaj +1 more source