Results 51 to 60 of about 25,973 (199)

PhageLeads: Rapid Assessment of Phage Therapeutic Suitability Using an Ensemble Machine Learning Approach

open access: yesViruses, 2022
The characterization of therapeutic phage genomes plays a crucial role in the success rate of phage therapies. There are three checkpoints that need to be examined for the selection of phage candidates, namely, the presence of temperate markers ...
Kumarasan Yukgehnaish   +8 more
doaj   +1 more source

Dual‐Targeted Biomimetic MoSe2 Nanozymes for Enhancing Peri‐Implant Soft Tissue Integration

open access: yesAdvanced Science, EarlyView.
A dual‐targeting biomimetic nanozyme, MoSe2@SPMM, selectively targets Staphylococcus aureus and oxidatively stressed macrophages. Near‐infrared activation couples contact‐enhanced photothermal bacterial eradication with reactive oxygen species scavenging to disrupt the pathogenic–immunological amplification loop.
Minghao Zhou   +7 more
wiley   +1 more source

Typing of Nontypable Staphylococci by Lysogeny [PDF]

open access: yesApplied Microbiology, 1967
Strains of coagulase-positive staphylococci which were nontypable with the routine typing set of phages could be typed by lysogeny with phage-propagating strains as indicators and with ultraviolet induction. About 10% of the strains could be typed without induction.
D, Chun, S D, Choi, J H, Suh, Y S, Moon
openaire   +2 more sources

Frenemy: adaptive temperate phage_SAP_1432 supports Staphylococcus aureus survival in changing temperatures

open access: yesMicrobiology Spectrum
It is important to understand how the presence of pathogens could benefit the survival of their hosts during climate change. In this study, we investigated the influence of the heat-resistant temperate phage phage_SAP_1432 on its bacterial host ...
Ting-ting Liu   +6 more
doaj   +1 more source

Autoreactivity Versus Autoimmunity: Characteristics of Autoantigen‐Specific CD4 T Cells in Rheumatoid Arthritis and Health

open access: yesArthritis &Rheumatology, EarlyView.
Objective CD4 T cells specific for citrullinated (cit) peptides are key players in rheumatoid arthritis (RA) immunopathogenesis. Characterizing these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next ...
James A. Stanway   +13 more
wiley   +1 more source

Bacteriophage 434 Hex Protein Prevents RecA-Mediated Repressor Autocleavage

open access: yesViruses, 2013
In a λimm434 lysogen, two proteins are expressed from the integrated prophage. Both are encoded by the same mRNA whose transcription initiates at the PRM promoter. One protein is the 434 repressor, needed for the establishment and maintenance of
Paul Shkilnyj   +2 more
doaj   +1 more source

Diversity and Host Interactions among Virulent and Temperate Baltic Sea Flavobacterium Phages

open access: yesViruses, 2020
Viruses in aquatic environments play a key role in microbial population dynamics and nutrient cycling. In particular, bacteria of the phylum Bacteriodetes are known to participate in recycling algal blooms.
Emelie Nilsson   +4 more
doaj   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

open access: yesBMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen   +9 more
wiley   +1 more source

Effect of Lysogeny on Serum Sensitivity [PDF]

open access: yesJournal of Bacteriology, 1968
WhenEscherichia coliK-12 was infected with λ phage and mutants of λ characterized by the production of temperature-sensitive repressors, the lysogenic bacteria were significantly more resistant to normal serum than the uninfected organisms. Infection ofE.
L H, Muschel, L A, Ahl, L S, Baron
openaire   +2 more sources

Microfluidic production of monodisperse food‐additive polymer capsules for biological applications

open access: yesDroplet, EarlyView.
Monodisperse TGPR polymer capsules are generated via a robust microfluidic approach exploiting droplet interface transfer across the oil‒water interface. Unlike lipid vesicles, these capsules offer high thermal stability and biocompatibility. They successfully demonstrated utility as robust bioreactors for in‐capsule PCR and bacterial cultivation ...
Yuki Gondo   +5 more
wiley   +1 more source

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