Results 61 to 70 of about 43,180 (285)
An HIV feedback resistor: auto-regulatory circuit deactivator and noise buffer. [PDF]
, 2006 Animal viruses (e.g., lentiviruses and herpesviruses) use transcriptional positive feedback (i.e., transactivation) to regulate their gene expression.
Shenk, Thomas, Weinberger, Leor S
core +4 more sources
Advanced Science, EarlyView.Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong +12 more
wiley +1 more source
Viruses, 2020 Burkholderia species have environmental, industrial and medical significance, and are important opportunistic pathogens in individuals with cystic fibrosis (CF).
Rebecca Weiser +6 more
doaj +1 more source
Exact Stochastic Simulation of Chemical Reactions with Cycle Leaping [PDF]
, 2006 The stochastic simulation algorithm (SSA), first proposed by Gillespie, has become the workhorse of computational biology. It tracks integer quantities of the molecular species, executing reactions at random based on propensity calculations.
Bruck, Jehoshua, Riedel, Marc D.
core
Comparative genomics of Shiga toxin encoding bacteriophages [PDF]
, 2012 Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, lifethreatening disease and Stx toxin is an integral virulence factor.
Allison, Heather +6 more
core +2 more sources
Principles for Rigorous Design and Application of Synthetic Microbial Communities
Advanced Science, EarlyView.SynComs are artificially designed to enable inter‐species metabolic interactions, metabolic division of labor, and ecological interactions that can elicit phenotypes like colonization stability and environmental adaptation. This systematic review explores the processes used to construct SynComs, the assessment of the mechanisms of metabolic interaction
Yuxiao Zhang +21 more
wiley +1 more source
Phage-Encoded LuxR-Type Receptors Responsive to Host-Produced Bacterial Quorum-Sensing Autoinducers
mBio, 2019 Quorum sensing (QS) is a process of cell-to-cell communication that bacteria use to orchestrate collective behaviors. QS relies on the cell-density-dependent production, accumulation, and receptor-mediated detection of extracellular signaling molecules ...
Justin E. Silpe, Bonnie L. Bassler
doaj +1 more source
Lysis, Lysogeny, and Virus-Microbe Ratios [PDF]
Nature, 2016 We show that neither the Piggyback-the-Winner model nor coral reef virome data presented in Knowles et al. [1] support a mechanistic link between increases in lysogeny, suppression of lysis, and the decline of the virus-to-microbial cell ratio (VMR) at high microbial cell densities across environmental and human-associated systems.
Weitz, Joshua S. +4 more
openaire +3 more sources
Advanced Science, EarlyView.This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li +22 more
wiley +1 more source
SVep1, a temperate phage of human oral commensal Streptococcus vestibularis
Frontiers in Microbiology, 2023 IntroductionBacteriophages play a vital role in the human oral microbiome, yet their precise impact on bacterial physiology and microbial communities remains relatively understudied due to the limited isolation and characterization of oral phages.
Miaomiao Wu +9 more
doaj +1 more source