Results 11 to 20 of about 47,686 (230)

Lysophosphatidic Acid and Glutamatergic Transmission [PDF]

Frontiers in Molecular Neuroscience, 2019
Signaling through bioactive lipids regulates nervous system development and functions. Lysophosphatidic acid (LPA), a membrane-derived lipid mediator particularly enriched in brain, is able to induce many responses in neurons and glial cells by affecting
Carolina Roza, José A. Campos-Sandoval, María C. Gómez-García, Ana Peñalver, Javier Márquez   +4 more
doaj   +8 more sources

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Lysophosphatidic Acid Synergizes With 1,25-Dihydroxyvitamin D to Promote Fibroblast Growth Factor-23 Synthesis via MAPK Signaling and Induction of the IL12A Gene. [PDF]

FASEB J
Ay et al. investigated the cellular mechanisms behind the role of lysophosphatidic acid (LPA) in FGF23 production. They revealed that LPA cooperates with 1,25‐dihydroxyvitamin D (1,25D), that is, the bioactive form of vitamin D known to stimulate FGF23 synthesis. This synergy entails MAPK signaling and the induction of the gene encoding the interleukin‐
Ay B, Cyr SM, Iwasaki Y, Hill E, Rhee EP, Singh NJ, Simic P, Bastepe M.   +7 more
europepmc   +2 more sources

Dual Role of Lysophosphatidic Acid Receptor 2 (LPA2) in Amyotrophic Lateral Sclerosis

Frontiers in Cellular Neuroscience, 2021
Lysophosphatidic acid (LPA) is a pleiotropic extracellular lipid mediator with many physiological functions that signal through six known G protein-coupled receptors (LPA1–6).
Maria Puigdomenech-Poch, Maria Puigdomenech-Poch, Anna Martínez-Muriana, Pol Andrés-Benito, Pol Andrés-Benito, Isidre Ferrer, Isidre Ferrer, Jerold Chun, Rubèn López-Vales, Rubèn López-Vales   +9 more
doaj   +1 more source

Lysophosphatidic acid, a growth factor-like lipid, in the saliva

Journal of Lipid Research, 2002
Lysophosphatidic acid is a multifunctional phospholipid mediator and elicits a variety of biological responses in vitro and in vivo. Evidence is accumulating that lysophosphatidic acid plays important physiological roles in diverse mammalian tissues and ...
Takayuki Sugiura, Shinji Nakane, Seishi Kishimoto, Keizo Waku, Yasuko Yoshioka, Akira Tokumura   +5 more
doaj   +1 more source

Supplementation of Culture Media with Lysophosphatidic Acid Improves The Follicular Development of Human Ovarian Tissue after Xenotransplantaion into The Back Muscle of γ-Irradiated Mice

Cell Journal, 2020
Objective: The aim of the present study was to evaluate the effects of lysophosphatidic acid (LPA) supplementation of human ovarian tissue culture media on tissue survival, follicular development and expression of apoptotic genes following ...
Zeynab Mohammadi, Nasim Hayati Roodbari, Kazem Parivar, Mojdeh Salehnia   +3 more
doaj   +1 more source

Physiopathological Implications of 7TM Receptors [PDF]

, 2010
Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core   +1 more source

Lysophosphatidic acid enhances stromal cell-directed angiogenesis. [PDF]

PLoS ONE, 2013
Ischemic diseases such as peripheral vascular disease (PVD) affect more than 15% of the general population and in severe cases result in ulcers, necrosis, and limb loss.
Bernard Y K Binder, Claus S Sondergaard, Jan A Nolta, J Kent Leach   +3 more
doaj   +1 more source

G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease [PDF]

, 2015
G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has garnered interest as a potential therapeutic target through its association with a range of diseases.
Amanda E Mackenzie, Graeme eMilligan, Nina eDivorty, Nina eDivorty, Stuart A. Nicklin   +4 more
core   +3 more sources

CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase

Journal of Lipid Research, 2010
Mutations in human CGI-58/ABHD5 cause Chanarin-Dorfman syndrome (CDS), characterized by excessive storage of triacylglycerol in tissues. CGI-58 is an α/β-hydrolase fold enzyme expressed in all vertebrates.
Gabriela Montero-Moran, Jorge M. Caviglia, Derek McMahon, Alexis Rothenberg, Vidya Subramanian, Zhi Xu, Samuel Lara-Gonzalez, Judith Storch, George M. Carman, Dawn L. Brasaemle   +9 more
doaj   +1 more source