Results 31 to 40 of about 47,347 (229)
Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
Nature Communications, 2016 Autotaxin generates the bioactive lipid lysophosphatidic acid to regulate diverse biological processes. Here, the authors identify a role for bile salts as direct allosteric inhibitors of autotaxin activity, suggesting that steroids may function as ...
Willem-Jan Keune +12 more
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Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolase
Journal of Lipid Research, 2012 Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that has a C-terminus epoxide hydrolase domain and an N-terminus phosphatase domain. The endogenous substrates of epoxide hydrolase are known to be epoxyeicosatrienoic acids, but the endogenous ...
Ami Oguro, Susumu Imaoka
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Effects of Pogostemon cablin on Serum Metabolomice of Guizhou Miniature Pigs and It's mechanism
Shiyan dongwu yu bijiao yixue, 2023 Objective Based on the liquid chromatography-tandem mass spectormetry (LC-MS/MS), to study the effects of Pogostemon cablin on serum metabolism of Guizhou miniature pigs， and to explore its pharmacological mechanism.
LU Taofeng +5 more
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Lysophosphatidic acid in atherosclerotic diseases [PDF]
British Journal of Pharmacology, 2012 Lysophosphatidic acid (LPA) is a potent bioactive phospholipid. As many other biological active lipids, LPA is an autacoid: it is formed locally on demand, and it acts locally near its site of synthesis. LPA has a plethora of biological activities on blood cells (platelets, monocytes) and cells of the vessel wall (endothelial cells, smooth muscle cells,
Andreas, Schober, Wolfgang, Siess
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LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells [PDF]
, 2017 Melanoma cells steer out of tumours using self-generated lysophosphatidic acid (LPA) gradients. The cells break down LPA, which is present at high levels around the tumours, creating a dynamic gradient that is low in the tumour and high outside.
Insall, Robert H. +10 more
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One lipid, two synaptic plasticity pathways. [PDF]
PLoS Biology, 2015 A new study identifies an unexpected role for lysophosphatidic acid in modulating the strength of both excitatory and inhibitory synapses in the brain, but by different mechanisms. Read the accompanying Research Article.
Richard Robinson
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Cells, 2021 Lysophosphatidic acid (LPA) is a bioactive lipid mediator primarily derived from membrane phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled receptors, termed LPA receptors (LPAR1 to LPAR6).
Yu-Hsuan Lin +2 more
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Lysophosphatidic Acid Signaling in Cancer [PDF]
Cancers, 2020 This Special Issue aims to highlight the impact of discoveries made over the last 25 years on the role of autotaxin (ATX) and lysophosphatidic acid (lysophosphatidate, LPA) signaling in tumor growth, metastasis and the treatment of cancers by chemotherapy, radiotherapy and immunotherapy [...]
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Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]
, 2019 Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C +4 more
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Lysophosphatidic Acid Induces Erythropoiesis through Activating Lysophosphatidic Acid Receptor 3
Stem Cells, 2011 AbstractLysophosphatidic acid (LPA), an extracellular lipid mediator, exerts multiple bioactivities through activating G protein-coupled receptors. LPA receptor 3 (LPA3) is a member of the endothelial differentiation gene family, which regulates differentiation and development of the circulation system. However, the relationship among the LPA receptors
Chiang, Chi-Ling +8 more
openaire +3 more sources