Results 91 to 100 of about 31,028 (221)

Interaction of Gα₁₂ with Gα₁₃ and Gα_q signaling pathways [PDF]

, 2002
The G(12) subfamily of heterotrimeric G-proteins consists of two members, G(12) and G(13). Gene-targeting studies have revealed a role for G(13) in blood vessel development. Mice lacking the a subunit of G(13) die around embryonic day 10 as the result of
Gu, Jennifer L., Mancino, Valeria, Müller, Stefan, Offermanns, Stefan, Simon, Melvin I.   +4 more
core  

ColoLipidGene: Signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients [PDF]

, 2015
Lipid metabolism plays an essential role in carcinogenesis due to the requirements of tumoral cells to sustain increased structural, energetic and biosynthetic precursor demands for cell proliferation. We investigated the association between expression
Aguayo, Cristina, Aparicio, Jorge, Burgos, Emilio, Cejas, Paloma, Custodio, Ana B., Espinosa-Salinas, Isabel, Feliu, Jaime, Fernández-Martos, Carlos, Gironella, Meritxell, González-Vallinas, Margarita, Herranz, Jesús, Las Rivas, Javier de, Machado, Isidro, Martín-Hernández, Roberto, Maurel, Joan, Mendiola, Marta, Molina, Susana, Moreno-Rubio, Juan, Ramos, David, Ramos, Ricardo, Ramírez de Molina, Ana, Reglero, Guillermo, Risueño, Alberto, Vargas, Teodoro, Yaya, Ricardo   +24 more
core   +4 more sources

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Lysophosphatidic acid and itsreceptors: Role in bronchial asthma pathogenesis

Acta Biomedica Scientifica
Lysophosphatidic acid (LPA) is a biologically active lipid mediator that regulates a number ofsignaling pathways involved in the pathogenesis of bronchial asthma.
O. Yu. Kytikova, T. P. Novgorodtseva, Yu. K. Denisenko   +2 more
doaj   +1 more source

Peripheral mechanisms of neuropathic pain – involvement of lysophosphatidic acid receptor-mediated demyelination

Molecular Pain, 2008
Recent advances in pain research provide a clear picture for the molecular mechanisms of acute pain; substantial information concerning plasticity that occurs during neuropathic pain has also become available.
Ueda Hiroshi
doaj   +1 more source

The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers. [PDF]

, 2014
G-protein coupled receptors (GPCRs) are among the most diverse and ubiquitous proteins in all of biology. The epidermal growth factor-seven span transmembrane (EGF-TM7) subfamily of adhesion GPCRs is a small subset whose members are mainly expressed on ...
Bloch, Orin, Ivan, Michael E, Kaur, Gurvinder, Oh, Michael C, Oh, Taemin, Parsa, Andrew T, Safaee, Michael, Sayegh, Eli T, Sun, Matthew Z   +8 more
core   +2 more sources

Lysophosphatidic Acid Receptor LPAR6 Supports the Tumorigenicity of Hepatocellular Carcinoma [PDF]

Cancer Research, 2015
Abstract The aberrant processes driving hepatocellular carcinoma (HCC) are not fully understood. Lysophosphatidic acid receptors (LPAR) are commonly overexpressed in HCC, but their contributions to malignant development are not well established.
MAZZOCCA, ANTONIO, DITURI, FRANCESCO, De Santis, Flavia, Filannino, Addolorata, Lopane, Chiara, Betz, Regina C., Li, Ying Yi, Mukaida, Naofumi, Winter, Peter, TORTORELLA, Cosimo, GIANNELLI, Gianluigi, SABBA', Carlo   +11 more
openaire   +4 more sources

Ginseng pharmacology: a new paradigm based on gintonin-lysophosphatidic acid receptor interactions

Frontiers in Pharmacology, 2015
Ginseng, the root of Panax ginseng, is used as a traditional medicine. Despite the long history of the use of ginseng, there is no specific scientific or clinical rationale for ginseng pharmacology besides its application as a general tonic.
Seung-Yeol eNah, Sun-Hye eChoi, Suk-Won eJung, Byung-Hwan eLee, Hyeon-Joong eKim, Sung-Hee eHwang, Ho-Kyung eKim   +6 more
doaj   +1 more source

Involvement of LPA Receptor 3 in LPA-induced BGC- 803 Cell Migration [PDF]

Mongolian Journal of Biological Sciences, 2013
Lysophosphatidic acid ˄ LPA ˅ is a bioactive phospholipid mediator, which elicits a variety of biological functions mainly through G-protein coupled receptors. Although LPA is shown to stimulate proliferation and motility via LPA receptors, LPAR1
Erdene Oyungerel, Tserennadmid Tseveensuren, Oyun Gansukh, Li Rui Juan, Alatangaole Damirin   +4 more
doaj   +1 more source

Marine n‐3 Polyunsaturated Fatty Acids Mitigate Obesity Traits Through PRDM16‐Driven Gene–Nutrient Interaction and Spatiotemporal Scale Browning Process

Food Frontiers, Volume 7, Issue 2, March 2026.
This large cohort study of 45,664 participants from the UK Biobank provides strong epidemiological evidence that fish oil use was associated with 12% and 7% lower risks of obesity and high body fat percentage, respectively. Mechanistically, marine n‐3 polyunsaturated fatty acids mitigate obesity traits through PRDM16‐driven gene–nutrient interactions ...
Xiaohui Liu, Haoyu Li, Youyou Zheng, Xiaoqian Chen, Xuzhi Wan, Pan Zhuang, Wei Jia, Jianxin Yao, Haoyin Liu, Hongbo Shi, Xunan Lin, Yu Zhang, Jingjing Jiao   +12 more
wiley   +1 more source