Results 21 to 30 of about 31,028 (221)

Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2016
Lysophosphatidic acid (LPA) signaling through one of its receptors, LPA1, contributes to both the development and the pathological remodeling after injury of many organs. Because we found previously that LPA-LPA1 signaling contributes to pulmonary fibrosis, here we investigated whether this pathway is also involved in lung development.
Manuela, Funke, Lars, Knudsen, David, Lagares, Simone, Ebener, Clemens K, Probst, Benjamin A, Fontaine, Alicia, Franklin, Manuela, Kellner, Mark, Kühnel, Stephanie, Matthieu, Roman, Grothausmann, Jerold, Chun, Jesse D, Roberts, Matthias, Ochs, Andrew M, Tager   +14 more
openaire   +2 more sources

Lysophosphatidic acid, a growth factor-like lipid, in the saliva

Journal of Lipid Research, 2002
Lysophosphatidic acid is a multifunctional phospholipid mediator and elicits a variety of biological responses in vitro and in vivo. Evidence is accumulating that lysophosphatidic acid plays important physiological roles in diverse mammalian tissues and ...
Takayuki Sugiura, Shinji Nakane, Seishi Kishimoto, Keizo Waku, Yasuko Yoshioka, Akira Tokumura   +5 more
doaj   +1 more source

A blocking peptide stabilizes lysophosphatidic acid receptor 1 and promotes lysophosphatidic acid-induced cellular responses. [PDF]

J Cell Biochem, 2021
AbstractG protein‐coupled receptors regulate a variety of cellular responses and have been considered as therapeutic targets for human diseases. Lysophosphatidic acid receptor 1 (LPA1) is a receptor for bioactive lysophospholipid, LPA. LPA/LPA1‐mediated signaling contributes to inflammatory and fibrotic responses in lung diseases; thus understanding ...
Taleb SJ, Wei J, Mialki RK, Dong S, Li Y, Zhao J, Zhao Y.   +6 more
europepmc   +3 more sources

G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease [PDF]

, 2015
G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has garnered interest as a potential therapeutic target through its association with a range of diseases.
Amanda E Mackenzie, Graeme eMilligan, Nina eDivorty, Nina eDivorty, Stuart A. Nicklin   +4 more
core   +3 more sources

Physiopathological Implications of 7TM Receptors [PDF]

, 2010
Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core   +1 more source

Gintonin facilitates brain delivery of donepezil, a therapeutic drug for Alzheimer disease, through lysophosphatidic acid 1/3 and vascular endothelial growth factor receptors

Journal of Ginseng Research, 2021
Background: Gintonin is a ginseng-derived exogenous G-protein–coupled lysophosphatidic acid (LPA) receptor ligand, which exhibits in vitro and in vivo functions against Alzheimer disease (AD) through lysophosphatidic acid 1/3 receptors.
Sun-Hye Choi, Na-Eun Lee, Hee-Jung Cho, Ra Mi Lee, Hyewhon Rhim, Hyoung-Chun Kim, Mun Han, Eun-Hee Lee, Juyoung Park, Seung-Yeol Nah   +9 more
doaj   +1 more source

2-arachidonoylglycerol metabolism is differently modulated by oligomeric and fibrillar conformations of amyloid beta in synaptic terminals [PDF]

, 2017
Alzheimer´s disease (AD) is the most prevalent disorder of senile dementia mainly characterized by amyloid-beta peptide (Aβ) deposits in the brain. Cannabinoids are relevant to AD as they exert several beneficial effects in many models of this disease ...
Gaveglio, Virginia Lucía, Giusto, Norma Maria, Pascual, Ana Clara, Pasquaré, Susana Juana   +3 more
core   +1 more source

Lysophosphatidic Acid Induces Erythropoiesis through Activating Lysophosphatidic Acid Receptor 3

Stem Cells, 2011
AbstractLysophosphatidic acid (LPA), an extracellular lipid mediator, exerts multiple bioactivities through activating G protein-coupled receptors. LPA receptor 3 (LPA3) is a member of the endothelial differentiation gene family, which regulates differentiation and development of the circulation system. However, the relationship among the LPA receptors
Chiang, Chi-Ling, Chen, Swey-Shen Alex, Lee, Shyh Jye, Tsao, Ku-Chi, Chu, Pei-Lun, Wen, Cheng-Hao, Hwang, Shiaw-Min, Yao, Chao-Ling, Lee, Hsinyu   +8 more
openaire   +3 more sources

Lysophosphatidic Acid (LPA) Induces Plasma Exudation and Histamine Release in Mice via LPA Receptors

Journal of Pharmacological Sciences, 2006
.: Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice.
Terumasa Hashimoto, Hisayuki Ohata, Kazuo Honda   +2 more
doaj   +1 more source

LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1β release. [PDF]

PLoS ONE, 2011
Lysophosphatidic acid (LPA) is a bioactive lipid inducing proliferation, differentiation as well as cytokine release by mast cells through G-protein coupled receptors. Recently GPR92/LPA5 was identified as an LPA receptor highly expressed by cells of the
Anders Lundequist, Joshua A Boyce
doaj   +1 more source