Results 81 to 90 of about 31,028 (221)

Lysophosphatidic acid (LPA) receptors: Signaling properties and disease relevance [PDF]

Prostaglandins & Other Lipid Mediators, 2010
Lysophosphatidic acid (LPA), a water-soluble phospholipid, has gained significant attention in recent years since the discovery that it acts as a potent signaling molecule with wide-ranging effects on many different target tissues. There are currently five identified G protein-coupled receptors for LPA and more are undergoing validation. The complexity
Mu-En, Lin, Deron R, Herr, Jerold, Chun
openaire   +2 more sources

Dietary anthocyanidin pelargonidin activates G protein‐coupled receptor 35

The FEBS Journal, EarlyView.
Pelargonidin, a red‐fruit‐derived anthocyanidin, was newly identified as a dietary agonist of GPR35, a metabolite‐sensing GPCR implicated in anti‐inflammation. Through screening of dietary compounds, pelargonidin emerged as a potent GPR35 agonist, attenuating inflammation in human intestinal cells.
Fumie Nakashima, Sayako Shimomura, Mayuka Wakabayashi, Wei Qi Loh, Harumi Ando, Haruka Sei, Hiroyuki Hattori, Didik Huswo Utomo, Masaki Kita, Asuka Inoue, Koji Uchida, Takahiro Shibata   +11 more
wiley   +1 more source

TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice [PDF]

, 2017
The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated.
Chiurchiù, Valerio, Giustizieri, Michela, Leuti, Alessandro, Lombardi, Marta, Maccarrone, Mauro, Marinelli, Sara, Marinelli, Silvia, Marrone, Maria Cristina, Mattioli, Marzia, Morabito, Annunziato, Murana, Emanuele, Oddi, Sergio, Piomelli, Daniele, Ragozzino, Davide Antonio, Riganti, Loredana, Totaro, Antonio, Verderio, Claudia   +16 more
core   +3 more sources

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, EarlyView.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source

The effect of lysophosphatidic acid on myometrial contractility and the mRNA transcription of its receptors in the myometrium at different stages of endometrosis in mares

BMC Veterinary Research
Background Endometrosis (chronic degenerative endometritis) results in morphological changes in the equine endometrium and impairs its secretory function. However, the effect of this condition on the myometrium remains unclear. Lysophosphatidic acid (LPA)
Katarzyna Karolina Piotrowska-Tomala, Anna Szóstek-Mioduchowska, Agnieszka Walentyna Jonczyk, Ewa Monika Drzewiecka, Michał Hubert Wrobel, Takuo Hojo, Graca Ferreira-Dias, Dariusz Jan Skarzynski   +7 more
doaj   +1 more source

Lysophosphatidic Acid Receptor Is a Functional Marker of Adult Hippocampal Precursor Cells

Stem Cell Reports, 2016
Here, we show that the lysophosphatidic acid receptor 1 (LPA1) is expressed by a defined population of type 1 stem cells and type 2a precursor cells in the adult mouse dentate gyrus.
Tara L. Walker, Rupert W. Overall, Steffen Vogler, Alex M. Sykes, Susann Ruhwald, Daniela Lasse, Muhammad Ichwan, Klaus Fabel, Gerd Kempermann   +8 more
doaj   +1 more source

Enhancement of P2X3 Receptor-Mediated Currents by Lysophosphatidic Acid in Rat Primary Sensory Neurons

Frontiers in Pharmacology, 2022
Lysophosphatidic acid (LPA), a lipid metabolite, plays a role in both neuropathic and inflammatory pain through LPA1 receptors. P2X3 receptor has also been shown to participate in these pathological processes.
Wen-Long Qiao, Wen-Long Qiao, Qing Li, Qing Li, Jia-Wei Hao, Jia-Wei Hao, Shuang Wei, Shuang Wei, Xue-Mei Li, Ting-Ting Liu, Chun-Yu Qiu, Wang-Ping Hu, Wang-Ping Hu   +12 more
doaj   +1 more source

Spatial Elucidation of Spinal Cord Lipid- and Metabolite-Regulations in Amyotrophic Lateral Sclerosis [PDF]

, 2014
Amyotrophic lateral sclerosis (ALS) is a devastating, rapidly progressing disease of the central nervous system that is characterized by motor neuron degeneration in the brain stem and the spinal cord.
Ewing, Andrew G, Hanrieder, Jörg
core   +2 more sources

Synthetic Biology and Metabolic Engineering of Microalgae for Sustainable Lipid and Terpenoid Production: An Updated Perspective

Plant Biotechnology Journal, EarlyView.
ABSTRACT Microalgae are increasingly recognised as powerful platforms for the sustainable production of lipids and terpenoids, with expanding applications in the food, fuel and biomanufacturing industries. In this updated review, we consolidate and critically assess the most recent advances in synthetic biology and metabolic engineering of key ...
Ty Shitanaka, Yu Wang, Sally Do, Julia Yuson, Samir Kumar Khanal, Krzysztof Zienkiewicz, Zhi‐Yan Du   +6 more
wiley   +1 more source

Lysophosphatidic Acid–Induced EGFR Transactivation Promotes Gastric Cancer Cell DNA Replication by Stabilizing Geminin in the S Phase

Frontiers in Pharmacology, 2021
Geminin, an inhibitor of the DNA replication licensing factor, chromatin licensing and DNA replication factor (Cdt) 1, is essential for the maintenance of genomic integrity. As a multifunctional protein, geminin is also involved in tumor progression, but
Haile Zhao, Gezi Gezi, Xiaoxia Tian, Peijun Jia, Morigen Morigen, Lifei Fan   +5 more
doaj   +1 more source