Results 111 to 120 of about 24,193 (235)

Gintonin absorption in intestinal model systems

Journal of Ginseng Research, 2018
Background: Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces [Ca2+]i transient-mediated morphological changes, proliferation, and migration in cells expressing ...
Byung-Hwan Lee, Sun-Hye Choi, Hyeon-Joong Kim, Sang-Deuk Park, Hyewhon Rhim, Hyoung-Chun Kim, Sung-Hee Hwang, Seung-Yeol Nah   +7 more
doaj   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, Volume 13, Issue 18, 27 March 2026.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels.

PLoS ONE, 2016
Hepatocellular carcinoma (HCC) commonly develops in patients with liver fibrosis; in these patients, the blood levels of lysophosphatidic acid (LPA) and its generating enzyme autotaxin (ATX) increase with the liver fibrosis stage. We aimed to examine the
Kenichiro Enooku, Baasanjav Uranbileg, Hitoshi Ikeda, Makoto Kurano, Masaya Sato, Hiroki Kudo, Harufumi Maki, Kazuhiko Koike, Kiyoshi Hasegawa, Norihiro Kokudo, Yutaka Yatomi   +10 more
doaj   +1 more source

Expression of lysophosphatidic acid receptors in the rat uterus: cellular distribution of protein and gestation-associated changes in gene expression. [PDF]

J Vet Med Sci, 2023
Kurusu S, Terashima R, Sugiyama M, Tanaka M, Kadowaki T, Kizaki K, Kawaminami M.   +6 more
europepmc   +1 more source

Localization of Puncta Adherentia Junctions at GABAergic Synapses on Parvalbumin‐Positive GABAergic Inhibitory Neurons in the Mouse Hippocampus

Journal of Comparative Neurology, Volume 534, Issue 3, March 2026.
Puncta adherentia junctions (PAJs) were observed not only at glutamatergic excitatory synapses on excitatory neurons (E→E synapses) but also at glutamatergic synapses on GABAergic inhibitory neurons (E→I synapses) and at GABAergic synapses on excitatory (I→E synapses) and inhibitory neurons (I→I synapses) in cultured mouse hippocampal neurons.
Kimitaka Katanazaka, Hajime Shiotani, Muneaki Miyata, Takeshi Kameyama, Shin Kedashiro, Ryouhei Komaki, Shota Nishii, Yutaro Kashiwagi, Yuka Sato, Shigeo Okabe, Norio Chihara, Riki Matsumoto, Kiyohito Mizutani, Yoshimi Takai   +13 more
wiley   +1 more source

The effect of clozapine on mRNA expression for genes encoding G protein-coupled receptors and the protein components of clathrin-mediated endocytosis. [PDF]

, 2013
Clathrin-mediated endocytosis (CME) is an intracellular trafficking mechanism for packaging cargo, including G protein-coupled receptors (GPCRs), into clathrin-coated vesicles (CCVs).
Gurling, HM, Hu, Y, Hunt, SP, McQuillin, A, Rizig, M, Sharp, SI, Weymer, JF   +6 more
core   +1 more source

Genetic Basis of Cuticular Hydrocarbon Variation in the Desert Ant Cataglyphis niger

Ecology and Evolution, Volume 16, Issue 3, March 2026.
Cuticular hydrocarbons (CHCs) are a ubiquitous component of ant cuticles that are used for a wide range of chemical signaling functions, especially recognition. Here we tested for a genetic basis of CHC variation in the desert ant Cataglyphis niger. We applied a genomic mapping approach to discover associations between CHCs and 20 quantitative trait ...
Shani Inbar, Besan Saied, Pnina Cohen, Zeev Frenkel, Yoann Pellen, Abraham B. Korol, Eyal Privman   +6 more
wiley   +1 more source

Lysophosphatidic acid receptors 2 and 3 regulate erythropoiesis at different hematopoietic stages. [PDF]

Biochim Biophys Acta Mol Cell Biol Lipids, 2021
Chiang JC, Chen WM, Lin KH, Hsia K, Ho YH, Lin YC, Shen TL, Lu JH, Chen SK, Yao CL, Chen BPC, Lee H.   +11 more
europepmc   +1 more source

Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells. [PDF]

, 2005
BackgroundDeregulation of the Wnt/ beta-catenin signal transduction pathway has been implicated in the pathogenesis of tumours in the mammary gland, colon and other tissues. Mutations in components of this pathway result in beta-catenin stabilization and
Ashworth, Alan, Enver, Tariq, Kenny, Paraic A   +2 more
core   +3 more sources

Lysophosphatidic acid receptor 1 inhibition: a potential treatment target for pulmonary fibrosis [PDF]

European Respiratory Review
Lysophosphatidic acid (LPA)-mediated activation of LPA receptor 1 (LPAR1) contributes to the pathophysiology of fibrotic diseases such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc). These diseases are associated with high morbidity and mortality despite current treatment options.
Volkmann, Elizabeth, Denton, Christopher, Kolb, Martin, Wijsenbeek-Lourens, Marlies, Emson, Claire, Hudson, Krischan, Amatucci, Anthony, Distler, Oliver, Allanore, Yannick, Khanna, Dinesh, Allanore, Yannick   +10 more
openaire   +8 more sources