Physiopathological Implications of 7TM Receptors [PDF]
, 2010 Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core +2 more sources
Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]
, 2006 Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Siess, Wolfgang
core +1 more source
Involvement of LPA Receptor 3 in LPA-induced BGC- 803 Cell Migration [PDF]
Mongolian Journal of Biological Sciences, 2013 Lysophosphatidic acid ˄ LPA ˅ is a bioactive phospholipid mediator, which elicits a variety of biological functions mainly through G-protein coupled receptors. Although LPA is shown to stimulate proliferation and motility via LPA receptors, LPAR1
Erdene Oyungerel +4 more
doaj +1 more source
G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease [PDF]
, 2015 G protein-coupled receptor 35 (GPR35) is an orphan receptor, discovered in 1998, that has garnered interest as a potential therapeutic target through its association with a range of diseases.
Amanda E Mackenzie +4 more
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The Function of NM23-H1/NME1 and Its Homologs in Major Processes Linked to Metastasis [PDF]
, 2020 International ...
Boissan, Mathieu +6 more
core +4 more sources
Lysophosphatidic Acid Induces Erythropoiesis through Activating Lysophosphatidic Acid Receptor 3
Stem Cells, 2011 AbstractLysophosphatidic acid (LPA), an extracellular lipid mediator, exerts multiple bioactivities through activating G protein-coupled receptors. LPA receptor 3 (LPA3) is a member of the endothelial differentiation gene family, which regulates differentiation and development of the circulation system. However, the relationship among the LPA receptors
Chiang, Chi-Ling +8 more
openaire +3 more sources
GPR35 in Intestinal Diseases: From Risk Gene to Function
Frontiers in Immunology, 2021 Diet and gut microbial metabolites mediate host immune responses and are central to the maintenance of intestinal health. The metabolite-sensing G-protein coupled receptors (GPCRs) bind metabolites and trigger signals that are important for the host cell
Berna Kaya +3 more
doaj +1 more source
2-arachidonoylglycerol metabolism is differently modulated by oligomeric and fibrillar conformations of amyloid beta in synaptic terminals [PDF]
, 2017 Alzheimer´s disease (AD) is the most prevalent disorder of senile dementia mainly characterized by amyloid-beta peptide (Aβ) deposits in the brain. Cannabinoids are relevant to AD as they exert several beneficial effects in many models of this disease ...
Gaveglio, Virginia Lucía +3 more
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Journal of Ginseng Research, 2021 Background: Gintonin is a ginseng-derived exogenous G-protein–coupled lysophosphatidic acid (LPA) receptor ligand, which exhibits in vitro and in vivo functions against Alzheimer disease (AD) through lysophosphatidic acid 1/3 receptors.
Sun-Hye Choi +9 more
doaj +1 more source
Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors. [PDF]
, 2012 The pluripotent nature of human embryonic stem cells (hESCs) makes them convenient for deriving therapeutically relevant cells. Here we show using Wnt reporter hESC lines that the cells are heterogeneous with respect to endogenous Wnt signalling activity.
Ardehali, Reza +4 more
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