Results 51 to 60 of about 24,337 (222)

Lateral access mechanism of LPA receptor probed by molecular dynamics simulation.

PLoS ONE, 2022
G-protein-coupled receptors (GPCR) are a family of membrane receptors that play important roles in the regulation of various physiological phenomena. LPA receptors (LPA1-6) are members of the class A GPCRs, which transduce a lysophosphatidic acid (LPA ...
Rieko Suenaga, Mizuki Takemoto, Asuka Inoue, Ryuichiro Ishitani, Osamu Nureki   +4 more
doaj   +1 more source

Controlling cancer through the autotaxin–lysophosphatidic acid receptor axis [PDF]

Biochemical Society Transactions, 2012
LPA (lysophosphatidic acid, 1-acyl-2-hydroxy-sn-glycero-3-phosphate), is a growth factor-like lipid mediator that regulates many cellular functions, many of which are unique to malignantly transformed cells. The simple chemical structure of LPA and its profound effects in cancer cells has attracted the attention of the cancer therapeutics field and ...
Mari, Gotoh, Yuko, Fujiwara, Junming, Yue, Jianxiong, Liu, SueChin, Lee, James, Fells, Ayako, Uchiyama, Kimiko, Murakami-Murofushi, Stephen, Kennel, Jonathan, Wall, Renukadevi, Patil, Renuka, Gupte, Louisa, Balazs, Duane D, Miller, Gabor J, Tigyi   +14 more
openaire   +3 more sources

Lysophosphatidic acid and itsreceptors: Role in bronchial asthma pathogenesis

Acta Biomedica Scientifica
Lysophosphatidic acid (LPA) is a biologically active lipid mediator that regulates a number ofsignaling pathways involved in the pathogenesis of bronchial asthma.
O. Yu. Kytikova, T. P. Novgorodtseva, Yu. K. Denisenko   +2 more
doaj   +1 more source

Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids

Journal of Lipid Research, 1996
An improved synthesis of two lipid phosphoric acids, N-palmitoyl-L-serine phosphoric acid (NP-Ser-PA) and N-palmitoyl-L-tyrosine phosphoric acid (NP-Tyr-PA), from the benzyl esters of L-serine and L-tyrosine is described.
R Bittman, B Swords, K Liliom, G Tigyi
doaj   +1 more source

Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors. [PDF]

, 2012
The pluripotent nature of human embryonic stem cells (hESCs) makes them convenient for deriving therapeutically relevant cells. Here we show using Wnt reporter hESC lines that the cells are heterogeneous with respect to endogenous Wnt signalling activity.
Ardehali, Reza, Blauwkamp, Timothy A, Nigam, Shelly, Nusse, Roel, Weissman, Irving L   +4 more
core   +1 more source

Advances in lysophosphatidic acid for bone remodeling [PDF]

Kouqiang yixue
Lysophosphatidic acid (LPA), a simple bioactive lysophospholipid widely dispersed in human body, has been reported to regulate the proliferation, chemotaxis and differentiation of multiple cells and further participate in various developmental and ...
ZHANG Qin, XIANG Lin, GONG Ping
doaj   +1 more source

Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact

Cell Reports, 2017
Vascular normalization in tumors may improve drug delivery and anti-tumor immunity. Angiogenesis inhibitors induce hypoxia, which may facilitate malignant progression; therefore, we investigated other methods to promote vascular maturation. Here, we show
Kazuhiro Takara, Daisuke Eino, Koji Ando, Daisuke Yasuda, Hisamichi Naito, Yohei Tsukada, Tomohiro Iba, Taku Wakabayashi, Fumitaka Muramatsu, Hiroyasu Kidoya, Shigetomo Fukuhara, Naoki Mochizuki, Satoshi Ishii, Haruhiko Kishima, Nobuyuki Takakura   +14 more
doaj   +1 more source

The Roles of Lpar1 in Central Nervous System Disorders and Diseases

Frontiers in Neuroscience, 2021
Lysophosphatidic acid receptor 1 (Lpar1), which is found in almost all human tissues but is most abundant in the brain, can couple to G protein-coupled receptors (GPCRs) and participate in regulating cell proliferation, migration, survival, and apoptosis.
Dongqiong Xiao, Dongqiong Xiao, Xiaojuan Su, Hu Gao, Xihong Li, Yi Qu   +5 more
doaj   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Phosphorylation and desensitization of the lysophosphatidic acid receptor LPA1 [PDF]

Biochemical Journal, 2005
In C9 cells, LPA (lysophosphatidic acid) induced inositol phosphate production, increased intracellular calcium concentration and inhibited adenylate cyclase activity. These responses were abolished in cells challenged with active phorbol esters. Action of phorbol esters was blocked by inhibitors of PKC (protein kinase C) and by its down-regulation ...
S Eréndira, Avendaño-Vázquez, Agustín, García-Caballero, J Adolfo, García-Sáinz   +2 more
openaire   +2 more sources