Results 71 to 80 of about 24,337 (222)
Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development
Mediators of Inflammation, 2017 Lysophosphatidic acid (LPA) is a ubiquitous lysophospholipid and one of the main membrane-derived lipid signaling molecules. LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA1–6, to induce
Silvia Anahi Valdés-Rives +1 more
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Enhancing adult hippocampal neurogenesis with lysophosphatidic acid: a proposal for erasing cocaine contextual memory [PDF]
, 2018 Stimulating adult hippocampal neurogenesis (AHN) has been uncovered as a promising approach in the manipulation of retrograde memories. This work aims to study whether increasing AHN with lysophosphatidic acid (LPA, an endogenous lysophospholipid with ...
Castilla Ortega, María Estela +9 more
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Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]
, 2019 Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C +4 more
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iMetaMed, EarlyView.Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen +4 more
wiley +1 more source
Lysophosphatidic acid (LPA) receptors: Signaling properties and disease relevance [PDF]
Prostaglandins & Other Lipid Mediators, 2010 Lysophosphatidic acid (LPA), a water-soluble phospholipid, has gained significant attention in recent years since the discovery that it acts as a potent signaling molecule with wide-ranging effects on many different target tissues. There are currently five identified G protein-coupled receptors for LPA and more are undergoing validation. The complexity
Mu-En, Lin, Deron R, Herr, Jerold, Chun
openaire +2 more sources
Eye and Brain, 2010 Eric Birgbauer, Jerold ChunDepartment of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, CA, USA Abstract: One of the major requirements in the development of the visual ...
Eric Birgbauer, Jerold Chun
doaj
Lysophosphatidic Acid (LPA) Induces Plasma Exudation and Histamine Release in Mice via LPA Receptors
Journal of Pharmacological Sciences, 2006 .: Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice.
Terumasa Hashimoto +2 more
doaj +1 more source
Lipids in Health and Disease, 2021 Background Lysophosphatidic acid (LPA) is a bioactive lysophospholipid that acts through its six cognate G protein-coupled receptors. As a family, lysophospholipids have already produced medicines (e.g., sphingosine 1-phosphate) as is being pursued for ...
Manisha Ray +3 more
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Frontiers in Endocrinology, 2022 Until now, the molecular mechanisms underlining sperm motility defect causing male infertility are still poorly understood. Safe and effective compounds or drugs that can improve sperm motility are also very limited.
Yinlam Li +14 more
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Lysophosphatidic Acid Induces Migration of Human Lung‐Resident Mesenchymal Stem Cells Through the β‐Catenin Pathway [PDF]
, 2012 Mesenchymal stem cells (MSCs) have been demonstrated to reside in human adult organs. However, mechanisms of migration of these endogenous MSCs within their tissue of origin are not well understood.
Anliker +33 more
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