Results 81 to 90 of about 24,337 (222)

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

Medicine Bulletin, EarlyView.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang, Changling Xu, Jiangang Fan, Renjie Chai   +3 more
wiley   +1 more source

Structural mechanisms of potent lysophosphatidic acid receptor 1 activation by nonlipid basic agonists

Communications Biology
Lysophosphatidic acid receptor 1 (LPA1) is one of the G protein-coupled receptors activated by the lipid mediator, lysophosphatidic acid (LPA). LPA1 is associated with a variety of diseases, and LPA1 agonists have potential therapeutic value for treating
Hiroaki Akasaka, Fumiya K. Sano, Wataru Shihoya, Osamu Nureki   +3 more
doaj   +1 more source

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, EarlyView.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake

eLife
Pancreatic ductal adenocarcinoma carries a dismal prognosis, with high rates of metastasis and few treatment options. Hyperactivation of KRAS in almost all tumours drives RAC1 activation, conferring enhanced migratory and proliferative capacity as well ...
Savvas Nikolaou, Amelie Juin, Jamie A Whitelaw, Nikki R Paul, Loic Fort, Colin Nixon, Heather J Spence, Sheila Bryson, Laura M Machesky   +8 more
doaj   +1 more source

The Function of NM23-H1/NME1 and Its Homologs in Major Processes Linked to Metastasis [PDF]

, 2020
International ...
Boissan, Mathieu, Farkas, Zsolt, Kopper, László, Mehta, Anil, Mátyási, Barbara, Sebestyén, Anna, Takács-Vellai, Krisztina   +6 more
core   +4 more sources

Redundant Glycerol‐3‐Phosphate Acyltransferases Regulate Thermo‐Sensitive Genic Male Sterility in Rice

Plant Biotechnology Journal, EarlyView.
ABSTRACT Thermo‐sensitive genic male sterility (TGMS) lines play a pivotal role in two‐line hybrid rice breeding. However, the availability of elite TGMS germplasm remains limited, and the molecular mechanisms underlying fertility transition of TGMS lines are still poorly understood.
Siqi Cheng, Hai Zheng, Yunlu Tian, Chaolong Wang, Xiaowen Yu, Kun Dong, Jian Wang, Jiayu Lu, Keyi Chen, Xiaodong He, Kun Shao, Junwen Gao, Bowen Yao, Yang Hu, Zhenwei Xie, Ling He, Zhao Xie, Yuantao Zhu, Song Guo, Dekun Lei, Anqi Jian, Xufei Zhu, Hao Yu, Shihao Zhang, Minrui Chen, Yun Chen, Ling Jiang, Yulong Ren, Xiuping Guo, Shijia Liu, Xi Liu, Shanshan Zhu, Zhigang Zhao, Jianmin Wan   +33 more
wiley   +1 more source

Novel lysophosphoplipid receptors: their structure and function

Journal of Lipid Research, 2014
It is now accepted that lysophospholipids (LysoGPs) have a wide variety of functions as lipid mediators that are exerted through G protein-coupled receptors (GPCRs) specific to each lysophospholipid.
Kumiko Makide, Akiharu Uwamizu, Yuji Shinjo, Jun Ishiguro, Michiyo Okutani, Asuka Inoue, Junken Aoki   +6 more
doaj   +1 more source

Activation of lysophosphatidic acid receptor type 1 (LPA1) contributes to pathophysiology of spinal cord injury [PDF]

, 2015
Altres ajuts: NIH/NS084398Lysophosphatidic acid (LPA) is an extracellular lipid mediator involved in many physiological functions that signals through six known G-protein-coupled receptors (LPA1-LPA6).
Astudillo, Alma M., Balsinde, Jesús, Chun, Jerold, Estivill-Torrus, Guillermo, Hernández Martín, Joaquim, Lago Pérez, Natalia, López Vales, Rubén, López-Serrano, Clara, Rodríguez de Fonseca Fernando, Santos Nogueira, Eva   +9 more
core   +3 more sources

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Lysophosphatidic Acid Receptor LPAR6 Supports the Tumorigenicity of Hepatocellular Carcinoma [PDF]

Cancer Research, 2015
Abstract The aberrant processes driving hepatocellular carcinoma (HCC) are not fully understood. Lysophosphatidic acid receptors (LPAR) are commonly overexpressed in HCC, but their contributions to malignant development are not well established.
MAZZOCCA, ANTONIO, DITURI, FRANCESCO, De Santis, Flavia, Filannino, Addolorata, Lopane, Chiara, Betz, Regina C., Li, Ying Yi, Mukaida, Naofumi, Winter, Peter, TORTORELLA, Cosimo, GIANNELLI, Gianluigi, SABBA', Carlo   +11 more
openaire   +4 more sources