Results 61 to 70 of about 24,337 (222)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model

, 2018
Background: The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life.
Elsadek, Bakheet, Maqboul, Ahmad
core   +2 more sources

Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells. [PDF]

, 2005
BackgroundDeregulation of the Wnt/ beta-catenin signal transduction pathway has been implicated in the pathogenesis of tumours in the mammary gland, colon and other tissues. Mutations in components of this pathway result in beta-catenin stabilization and
Ashworth, Alan, Enver, Tariq, Kenny, Paraic A   +2 more
core   +3 more sources

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Abrogation of lysophosphatidic acid receptor 1 ameliorates murine vasculitis [PDF]

Arthritis Research & Therapy, 2019
Lysophosphatidic acid (LPA), generated by autotaxin (ATX), is a bioactive lipid mediator that binds to the receptors (LPA1-6), and serves as an important mediator in inflammation. Previous studies have demonstrated that LPA-LPA1 cascade contributes to arthritis and skin sclerosis.
Chie Miyabe, Yoshishige Miyabe, Jun Nagai, Noriko N. Miura, Naohito Ohno, Jerold Chun, Ryoji Tsuboi, Hiroshi Ueda, Masayuki Miyasaka, Nobuyuki Miyasaka, Toshihiro Nanki   +10 more
openaire   +3 more sources

Lysophosphatidic Acid Induces Apoptosis of PC12 Cells Through LPA1 Receptor/LPA2 Receptor/MAPK Signaling Pathway

Frontiers in Molecular Neuroscience, 2020
Lysophosphatidic acid is a small extracellular signaling molecule, which is elevated in pathological conditions such as ischemic stroke and traumatic brain injury (TBI). LPA regulates the survival of neurons in various diseases.
Jie Zhang, Yiyi Li, Chao Wang, Yaya Wang, Yangyang Zhang, Liqin Huang, Zhaohui Zhang   +6 more
doaj   +1 more source

PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex [PDF]

, 2017
PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signalling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β ...
Anderson, Anthony, Barnes, Boehm, Boisvert, Bos, Campbell, Cantley, Capes-Davis, Caserta, Clevers, Corbalán-García, Crossman, Deevi, Deevi, Dubois, Dubois, Durgan, Décaillot, Eisenmann, Enslen, Eroglu, Furia, Ge, Glover, Hanahan, Hao, Hietakangas, Irazoqui, Jaffe, Jagan, Jagan, Jia, Johnston, Klompstra, Kovacs, Kumari, Lee, Lee, Leslie, Li, Lima-Fernandes, Lima-Fernandes, Liu Tj, Luttrell, Ma, Magudia, Maier, Martin-Belmonte, Meitinger, Meuillet, Misticone, Morin, Nagasaki, Naguib, Naguib, Narbonne, Noda, Ogg, Oh, Pertz, Pálmer, Raftopoulou, Raftopoulou, Rahdar, Rock, Rouault, Salmena, Sanchez, Sato, Shukla, Slorach, Smith, Song, Song, Söderberg, Tait, Torres, Ueda, Urs, Walker, Weng, Yun   +82 more
core   +3 more sources

The Role of Lysophosphatidic Acid in Neuropsychiatric and Neurodegenerative Disorders

Future Pharmacology
Individuals suffering from diverse neuropsychiatric and neurodegenerative disorders often have comparable symptoms, which may underline the implication of shared hereditary influences and the same biological processes.
Simona Dedoni, Chiara Camoglio, Carlotta Siddi, Maria Scherma, Walter Fratta, Paola Fadda   +5 more
doaj   +1 more source