Results 51 to 60 of about 39,610 (238)

Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis [PDF]

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2012
Isolated hepatocytes undergo lipoapoptosis, a feature of hepatic lipotoxicity, on treatment with saturated free fatty acids (FFA) such as palmitate (PA). However, it is unknown if palmitate is directly toxic to hepatocytes or if its toxicity is indirect via the generation of lipid metabolites such as lysophosphatidylcholine (LPC).
Keisuke, Kakisaka, Sophie C, Cazanave, Christian D, Fingas, Maria E, Guicciardi, Steven F, Bronk, Nathan W, Werneburg, Justin L, Mott, Gregory J, Gores   +7 more
openaire   +2 more sources

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

Lipidomic Profile Analysis of Lung Tissues Revealed Lipointoxication in Pulmonary Veno-Occlusive Disease

Biomolecules, 2022
Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary arterial hypertension (PAH) occurring in a heritable form (hPVOD) due to biallelic inactivating mutations of EIF2AK4 (encoding GCN2, general control nonderepressible 2) or in a sporadic ...
Spiro Khoury, Antoine Beauvais, Jenny Colas, Anaïs Saint-Martin Willer, Frédéric Perros, Marc Humbert, Clarisse Vandebrouck, David Montani, Thierry Ferreira, Fabrice Antigny   +9 more
doaj   +1 more source

Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers [PDF]

, 2011
Metabolomic profiling and the integration of whole-genome genetic association data has proven to be a powerful tool to comprehensively explore gene regulatory networks and to investigate the effects of genetic variation at the molecular level.
A Brandstätter, A Döring, A Köttgen, A Lorber, AA Hicks, Alexey Polonikov, AM Kim, Annette Peters, C Gieger, Christian Gieger, CM Rodrigues, CM Slupsky, CM Tingen, Cornelia Prehn, D Fairweather, Fabian J. Theis, Florian Kronenberg, G Paré, H Löwel, H-E Wichmann, Heinz Erich Wichmann, I Pe'er, J Krumsiek, J Nikkilä, J Yeboah, Jan Krumsiek, Janina S. Ried, Jerzy Adamski, JQ Purnell, Karsten Suhre, Kirstin Mittelstrass, LA Lange, M Steffens, Mark I. McCarthy, ML Summar, P Filzmoser, R Holle, R Paternoster, Rui Wang-Sattler, SE Geller, SE Reuter, Stephan Weidinger, T Illig, Thomas Illig, Thomas Meitinger, W Mostertz, Werner Roemisch-Margl, WL Holland, YS Aulchenko, Zhonghao Yu   +49 more
core   +4 more sources

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

An advanced method for propargylcholine phospholipid detection by direct-infusion MS

Journal of Lipid Research, 2021
Phospholipids with a choline head group are an abundant component of cellular membranes and are involved in many important biological functions. For studies on the cell biology and metabolism of these lipids, traceable analogues where propargylcholine ...
Mohamed H. Yaghmour, Christoph Thiele, Lars Kuerschner   +2 more
doaj   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Role of lysophosphatidic acid in the regulation of uterine leiomyoma cell proliferation by phospholipase D and autotaxin

Journal of Lipid Research, 2008
Phospholipase D (PLD) hydrolyzes phosphatidylcholine into phosphatidic acid (PA), a lipidic mediator that may act directly on cellular proteins or may be metabolized into lysophosphatidic acid (LPA).
Emmanuelle Billon-Denis, Zahra Tanfin, Philippe Robin   +2 more
doaj   +1 more source

Analysis of Polar Lipids in Hemp (Cannabis sativa L.) By-Products by Ultra-High Performance Liquid Chromatography and High-Resolution Mass Spectrometry

Molecules, 2022
Polar lipids were extracted from residual biomass of hemp (Cannabis sativa L.) by-products with EtOH and partitioned into aqueous and chloroform fractions.
Arjun H. Banskota, Alysson Jones, Joseph P. M. Hui, Roumiana Stefanova, Ian W. Burton   +4 more
doaj   +1 more source

Phospholipid composition and kinetics in different endobronchial fractions from healthy volunteers [PDF]

, 2014
Tracheal secretions may be of value as a surrogate to assess bronchoalveolar lavage fluid surfactant molecular composition and metabolism in healthy people.
Cusack, Rebecca, Dushianthan, Ahilanandan, Goss, Victoria, Grocott, Michael P.W., Postle, Anthony D.   +4 more
core   +1 more source