Results 91 to 100 of about 7,434 (235)

Oleoylethanolamide regulates intestinal stem cell activity and villus size via PPARα signaling pathway

iMetaOmics, EarlyView.
First use of a natural swine model with lipid metabolism to directly link lipid differences to a quantifiable intestinal villus height phenotype. Identified the phospholipid‐derived oleoylethanolamide, rather than canonical fatty acids, as the endogenous primary ligand that activates peroxisome proliferator‐activated receptors α (PPARα) to enlarge ...
Qianqian Wang, Lanmei Yin, Zhaobin Wang, Jun Li, Xianglin Zeng, Qiye Wang, Jianzhong Li, Kang Xu, Huansheng Yang, Yulong Yin   +9 more
wiley   +1 more source

Effects of organically and conventionally produced feed on biomarkers of health in a chicken model [PDF]

Consumers expect organic products to be healthier. However, limited research has been performed to study the effect of organic food on health. The present study aimed to identify biomarkers of health to enable future studies in human subjects.
Coulier, L., Greef, J., de, Hoogenboom, R.A.P., Huber, M., Nierop, D., Parmentier, H.K., Savelkoul, H.F.J., Verheij, E., Vijver, L.P.L., van de, Wopereis, S.   +9 more
core   +2 more sources

A Metabolomic Signature of Acute Caloric Restriction [PDF]

, 2017
Context: The experimental paradigm of acute caloric restriction followed by refeeding can be used to study the homeostatic mechanisms that regulate energy homeostasis, which are relevant to understanding the adaptive response to weight loss.
Collet, TH, Farooqi, IS, Guo, L, Henning, E, Ingram, B, Kelway, S, Keogh, JM, Sonoyama, T   +7 more
core   +2 more sources

Peripheral versus Marrow Lipidomics in Patients with Severe Aplastic Anemia: Potential Indicators for Early Immunosuppressive Treatment Response

Lipids, EarlyView.
ABSTRACT This study aimed to explore the differences of peripheral blood (PB) and bone marrow serum lipidomic profiles in severe aplastic anemia (SAA) patients and their significance in predicting earlier immunosuppressive therapy (IST) response. A cohort of 11 newly diagnosed SAA patients and 15 healthy controls were enrolled between June 2020 and ...
Zexing Sun, Yilei Hong, Yaonan Hong, Chuanao Xin, Qi Liu, Huijin Hu, Yingying Shen, Ying Chen, Shan Liu, Yiping Shen, Yuhong Zhou, Dijiong Wu   +11 more
wiley   +1 more source

Multi-Omics Analyses Detail Metabolic Reprogramming in Lipids, Carnitines, and Use of Glycolytic Intermediates between Prostate Small Cell Neuroendocrine Carcinoma and Prostate Adenocarcinoma. [PDF]

, 2019
As the most common cancer in men, prostate cancer is molecularly heterogeneous. Contributing to this heterogeneity are the poorly understood metabolic adaptations of the two main types of prostate cancer, i.e., adenocarcinoma and small cell ...
Alumkal, Joshi J, Fan, Sili, Fiehn, Oliver, Gao, Bei, Lue, Hui-Wen, Podolak, Jennifer, Serawat, Archana, Thomas, George V, Zhang, Ying   +8 more
core   +1 more source

Stratum Corneum Ceramide Abnormalities in Atopic Dermatitis: Pathophysiology and Implications for Disease Management

The Journal of Dermatology, EarlyView.
ABSTRACT The stratum corneum, as the outermost layer of the skin, functions as a critical barrier that maintains cutaneous hydration and systemic homeostasis. Among its structural lipids, ceramides constitute the most abundant and diverse component. These molecules are essential for the formation of lamellar structures that secure barrier integrity ...
Takashi Sakai
wiley   +1 more source

Untargeted UPLC-MS Profiling Pipeline to Expand Tissue Metabolome Coverage: Application to Cardiovascular Disease. [PDF]

, 2015
Metabolic profiling studies aim to achieve broad metabolome coverage in specific biological samples. However, wide metabolome coverage has proven difficult to achieve, mostly because of the diverse physicochemical properties of small molecules ...
Alun H. Davies, Beltran A., Cubbon S., Elaine Holmes, Eliasson M., Elizabeth J. Want, Fahy E., Geier F. M., Gika H. G., Gika H. G., Giorgis Isaac, Gray N., Hao Z., Idborg H., Ismail N. A., Ivanisevic J., Jeremy K. Nicholson, Kanehisa M., Masson P., Mirnezami R., Muzaffar A. Anwar, Naz S., Nicholson J. K., Panagiotis A. Vorkas, Plumb R. S., Saric J., Schmidt C., Smith C. A., Spagou K., Spagou K., Vorkas P. A., Waldram A., Want E. J., Wishart D. S.   +33 more
core   +5 more sources

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Artificial reproduction of sturgeon: The correlation between the lipid composition of caviar and it fish breeding quality [PDF]

BIO Web of Conferences
In our research we study of the correlation between the biochemical composition of unfertilized sturgeon caviar and the results of its incubation. We studies besters (bester is a hybrid of beluga and sterlet) and stellate sturgeon caviar.
Vassel Sergei, Vassel Natalia
doaj   +1 more source

Prostaglandin D2 Synthase Controls Schwann Cells Metabolism and Peripheral Myelin Homeostasis [PDF]

Glia
Prostaglandin D2 Synthase (L‐PGDS) controls PPNS myelin lipids’ composition and Schwann cells energetic metabolism In the absence of L‐PGDS Schwann cells turn to acetate as the main energetic source. These metabolic changes result in ketone bodies production to preserve neuronal survival.
Trimarco A, Audano M, La Marca R, Pellegatta M, Canevazzi P, Cariello M, Falco M, Pedretti S, Imperato G, Cestaro A, Podini P, Dina G, Quattrini A, Massimino L, Caruso D, Mitro N, Taveggia C.   +16 more
europepmc   +2 more sources