Results 101 to 110 of about 7,531 (229)

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Plasma lipid metabolites as biomarkers of early white matter degeneration in Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Alzheimer's disease (AD) is characterized by progressive white matter (WM) degeneration. Circulating lipid metabolites may serve as early indicators of WM microstructural changes.
Alireza Shaabanpoor Haghighi, Hamide Nasiri, Arman Ghayourvahdat, Hannaneh Azimizonuzi, Negar Ghasemi, Meysam Mansouri, Arya Moftakhar Bazkiaei, Mohammad Amir Amirian, Sevda Zeinali, Hamed Gozali, Rezvaneh Rostami, Maryam Ayobi, Alzheimer's Disease Neuroimaging Initiative   +12 more
doaj   +1 more source

Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia

Journal of Translational Medicine, 2019
Background There continues to be a great need for better biomarkers and host-directed treatment targets for community-acquired pneumonia (CAP). Alterations in phospholipid metabolism may constitute a source of small molecule biomarkers for acute ...
Haroon Arshad, Juan Carlos López Alfonso, Raimo Franke, Katina Michaelis, Leonardo Araujo, Aamna Habib, Yuliya Zboromyrska, Eva Lücke, Emilia Strungaru, Manas K. Akmatov, Haralampos Hatzikirou, Michael Meyer-Hermann, Astrid Petersmann, Matthias Nauck, Mark Brönstrup, Ursula Bilitewski, Laurent Abel, Jorg Sievers, Jordi Vila, Thomas Illig, Jens Schreiber, Frank Pessler   +21 more
doaj   +1 more source

Nuclear magnetic resonance spectroscopy based metabolomics to identify novel biomarkers of alcohol-dependence [PDF]

, 2017
Alcohol misuse is a ravaging public health and social problem. Its harm can affect the drinkers and the whole society. Alcohol-dependence is a phase of alcohol misuse in which the drinker consumes excessive amounts of alcohol and has a continuous urge ...
Arif, Nor Hayati, Ibrahim, Baharudin, M. Amin, Arwa, Mostafa, Hamza, Murugaiyah, Vikneswaran   +4 more
core   +2 more sources

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

A Metabolomic Signature of Acute Caloric Restriction [PDF]

, 2017
Context: The experimental paradigm of acute caloric restriction followed by refeeding can be used to study the homeostatic mechanisms that regulate energy homeostasis, which are relevant to understanding the adaptive response to weight loss.
Collet, TH, Farooqi, IS, Guo, L, Henning, E, Ingram, B, Kelway, S, Keogh, JM, Sonoyama, T   +7 more
core   +2 more sources

The Human Urine Metabolome [PDF]

, 2013
Urine has long been a “favored” biofluid among metabolomics researchers. It is sterile, easy-to-obtain in large volumes, largely free from interfering proteins or lipids and chemically complex.
Aziat, Farid, Bjorndahl, Trent C., Bogumil, Ralf, Bouatra, Souhaila, Dame, Zerihun T., Dong, Edison, Guo, An Chi, Huynh, Jessica, Knox, Craig, Krishnamurthy, Ramanarayan, Liu, Philip, Mandal, Rupasri, Poelzer, Jenna, Psychogios, Nick, Roehring, Cornelia, Saleem, Fozia, Wilson, Michael R., Wishart, David S., Yallou, Faizath S.   +18 more
core   +3 more sources

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Monitoring cancer prognosis, diagnosis and treatment efficacy using metabolomics and lipidomics [PDF]

, 2016
Introduction: Cellular metabolism is altered during cancer initiation and progression, which allows cancer cells to increase anabolic synthesis, avoid apoptosis and adapt to low nutrient and oxygen availability.
Armitage, Emily G., Southam, Andrew D.
core   +2 more sources

Peripheral versus Marrow Lipidomics in Patients with Severe Aplastic Anemia: Potential Indicators for Early Immunosuppressive Treatment Response

Lipids, EarlyView.
ABSTRACT This study aimed to explore the differences of peripheral blood (PB) and bone marrow serum lipidomic profiles in severe aplastic anemia (SAA) patients and their significance in predicting earlier immunosuppressive therapy (IST) response. A cohort of 11 newly diagnosed SAA patients and 15 healthy controls were enrolled between June 2020 and ...
Zexing Sun, Yilei Hong, Yaonan Hong, Chuanao Xin, Qi Liu, Huijin Hu, Yingying Shen, Ying Chen, Shan Liu, Yiping Shen, Yuhong Zhou, Dijiong Wu   +11 more
wiley   +1 more source