Results 101 to 110 of about 7,434 (235)

Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei [PDF]

, 2013
n vitro culture methods underpin many experimental approaches to biology and drug discovery. The modification of established cell culture methods to make them more biologically relevant or to optimize growth is traditionally a laborious task.
Alsford, Alsford, Baltz, Barrett, Berger, Berger, Bitonti, Bowling, Bradley, Breitling, Brun, Brunda Nijagal, Creek, Creek, Creek, Darren J. Creek, de Koning, Dong-Hyun Kim, Drexler, Duszenko, Duszenko, Federico Rojas, Geary, Haanstra, Hasne, Hirumi, Hirumi, Hirumi, Jacobs, Keith R. Matthews, Kuettel, Kwon, Lanteri, Lanteri, Mashego, Michael P. Barrett, Mäser, Räz, Saunders, Scalbert, Scheltema, Scheltema, Seed, Sienkiewicz, Smith, Sumner, Sykes, t'Kindt, Tautenhahn, Vincent, Wang, Ward, Wilson, Winder, Wishart, Wu, Zaboikin, Zang, Zhang   +58 more
core   +2 more sources

LPC18:0 Secreted by Exogenous Neural Stem Cells Potentiates Neurogenesis and Functional Recovery via GPR55‐Mediated Signalling in Spinal Cord Injury

Cell Proliferation, EarlyView.
LPC18:0 secreted by exogenous neural stem cells potentiates neurogenesis via the GPR55/AKT/GSK3β signalling axis, which ultimately promotes spinal cord injury recovery. ABSTRACT Spinal cord injury (SCI) is a devastating condition with limited therapeutic options. Although neural stem cell (NSC) transplantation shows regenerative potential, its efficacy
Dong Chen, Shuo Liu, Le‐Yi Tu, Ming‐Mei Yang, Cong‐Wang Xu, Yue Jiang, Hui Yang, Chen‐Xu Tai, Yan‐Ning Wang, Yuan‐Yuan Xie, Ping‐Ping Shen, Bin Wang   +11 more
wiley   +1 more source

Investigating plasma lipid profiles in association with Parkinson’s disease risk

npj Parkinson's Disease
Parkinson’s Disease (PD) is associated with lipid metabolic disturbances, but the specific roles of lipids in its pathogenesis are unclear. This Mendelian Randomization (MR) study utilized GWAS data and IVW methods to investigate plasma lipids and PD ...
Houwen Zhang, Fangzheng Cao, Jialin Yu, Yu Liang, You Wu   +4 more
doaj   +1 more source

Serum lysophosphatidylcholines to phosphatidylcholines ratio is associated with symptomatic responders to symptomatic drugs in knee osteoarthritis patients

Arthritis Research & Therapy, 2019
Background Identification of the optimal treatment for a given patient is of paramount importance. This is of particular relevance in osteoarthritis (OA) because of the high prevalence of the disease, extensive heterogeneity of the disease, and need for ...
Guangju Zhai, Jean-Pierre Pelletier, Ming Liu, Edward W. Randell, Proton Rahman, Johanne Martel-Pelletier   +5 more
doaj   +1 more source

The Human Urine Metabolome [PDF]

, 2013
Urine has long been a “favored” biofluid among metabolomics researchers. It is sterile, easy-to-obtain in large volumes, largely free from interfering proteins or lipids and chemically complex.
Aziat, Farid, Bjorndahl, Trent C., Bogumil, Ralf, Bouatra, Souhaila, Dame, Zerihun T., Dong, Edison, Guo, An Chi, Huynh, Jessica, Knox, Craig, Krishnamurthy, Ramanarayan, Liu, Philip, Mandal, Rupasri, Poelzer, Jenna, Psychogios, Nick, Roehring, Cornelia, Saleem, Fozia, Wilson, Michael R., Wishart, David S., Yallou, Faizath S.   +18 more
core   +3 more sources

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Investigation into the delivery and evaluation of a unique Avena sativa (Oat) Lipid Extract on skin barrier using LC‒MS/MS, Raman spectroscopy, immunostaining analysis and skin efficacy

International Journal of Cosmetic Science, EarlyView.
Abstract Objectives Oat lipids are rich in ceramides. In this investigation, we analysed the delivery of a specific Oat Lipid Extract derived from Avena sativa, comprising ‘skin identical’ ratios of fatty acids, ceramides and cholesterol/sterol. This investigation is the first reported investigation of oat lipids utilizing Raman spectroscopy for the ...
E. Gombert, C. Dewis
wiley   +1 more source

High-grade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism [PDF]

, 2017
Ovarian cancer is a very severe type of disease with poor prognosis. Treatment of ovarian cancer is challenging because of the lack of tests for early detection and effective therapeutic targets.
Braicu, Elena Ioana, Budczies, Jan, Darb-Esfahani, Silvia, Denkert, Carsten, Dietel, Manfred, Frezza, Christian, Heiskanen, Laura, Hilvo, Mika, Koistinen, Kaisa M., Kuhberg, Marc, Pöhö, Päivi, Schmitt, Wolfgang D., Sehouli, Jalid   +12 more
core   +3 more sources

Methods for the preparation of lysophosphatidylcholine

Journal of Pharmacy and Pharmacology, 1971
Abstract The surfactant and solubilizing properties of lysophosphatidylcholine (LPC) could have industrial uses if it became available in technical quantity and purity. The two most promising routes for obtaining it are isolation from cereal starches and mono-deacylation of egg phosphatidylcholine (PC). Baker's yeast autolysed by Letters'
D S, Merryfield, J J, Wren
openaire   +2 more sources

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, EarlyView.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source