Generation and characterization of a mitotane-resistant adrenocortical cell line [PDF]
, 2020 Mitotane is the only drug approved for the therapy of adrenocortical carcinoma (ACC). Its clinical use is limited by the occurrence of relapse during therapy.
Bachmann, Sebastian +14 more
core +2 more sources
Lipidomic analysis of plasma samples from women with polycystic ovary syndrome [PDF]
, 2015 Polycystic ovary syndrome (PCOS) is a common disorder affecting between 5 and 18 % of females of reproductive age and can be diagnosed based on a combination of clinical, ultrasound and biochemical features, none of which on its own is diagnostic.
A Dunaif +40 more
core +1 more source
Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers [PDF]
, 2011 Metabolomic profiling and the integration of whole-genome genetic association data has proven to be a powerful tool to comprehensively explore gene regulatory networks and to investigate the effects of genetic variation at the molecular level.
A Brandstätter +49 more
core +6 more sources
Plasma lipid profiling of different types of hepatic fibrosis induced by carbon tetrachloride and lomustine in rats [PDF]
, 2016 Supplementary tables. Table S1. Class, m/z, retention time, ion of detected and identified lipid molecules, and determined their fatty side chains. Table S2. Normalized levels of lipid molecules in individual samples. Table S3. Fold change and p-value of
Hiroshi Yamada +5 more
core +2 more sources
Practical Laboratory Medicine, 2023 Background and objectives: Very long-chain fatty acyl-lysophosphatidylcholines (VLCFA-LysoPCs) are measured in dried blood spots (DBS) for identifying X-linked adrenoleukodystrophy (X-ALD) and other inherited peroxisomal disorders.
Archana Natarajan, Rita Christopher
doaj +1 more source
Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes [PDF]
, 2012 BACKGROUND: Obesity and type 2 diabetes (T2DM) are associated with increased circulating free fatty acids and triacylglycerols. However, very little is known about specific molecular lipid species associated with these diseases.
AD Karelis +36 more
core +3 more sources
Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes
Annals of Clinical and Translational Neurology, 2022 Objective The serum lipidomic profile associated with neuropathy in type 2 diabetes is not well understood. Obesity and dyslipidemia are known neuropathy risk factors, suggesting lipid profiles early during type 2 diabetes may identify individuals who ...
Farsad Afshinnia +11 more
doaj +1 more source
Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response [PDF]
, 2019 Insulin and insulin-like signaling regulates a broad spectrum of growth and metabolic responses to a variety of internal and environmental stimuli. For example, the inhibition of insulin-like signaling in C.
Baugh, Lauren +5 more
core +1 more source
Doubled lifespan and patient‐like pathologies in progeria mice fed high‐fat diet [PDF]
, 2019 Hutchinson-Gilford Progeria Syndrome (HGPS) is a devastating premature aging disease. Mouse models have been instrumental for understanding HGPS mechanisms and for testing therapies, which to date have had only marginal benefits in mice and patients ...
Albert, Carolyn J +10 more
core +2 more sources
Marine Drugs, 2020 Microalgae have been shown to be excellent producers of lipids, pigments, carbohydrates, and a plethora of secondary metabolites with possible applications in the pharmacological, nutraceutical, and cosmeceutical sectors. Recently, various microalgal raw
Chiara Lauritano +5 more
doaj +1 more source