Results 21 to 30 of about 7,531 (229)

The maternal blood lipidome is indicative of the pathogenesis of severe preeclampsia

Journal of Lipid Research, 2021
Preeclampsia is a pregnancy-specific syndrome characterized by hypertension and proteinuria after 20 weeks of gestation. However, it is not well understood what lipids are involved in the development of this condition, and even less is known how these ...
Bing He, Yu Liu, Mano R. Maurya, Paula Benny, Cameron Lassiter, Hui Li, Shankar Subramaniam, Lana X. Garmire   +7 more
doaj   +1 more source

Metabolic Profiling of Plasma in Different Calving Body Condition Score Cows Using an Untargeted Liquid Chromatography-Mass Spectrometry Metabolomics Approach

Animals, 2020
This study was undertaken to identify metabolite differences in plasma of dairy cows with a normal or high calving body condition score (CBCS), using untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics.
Jian Wang, Chuang Zhang, Qingyao Zhao, Congcong Li, Shuang Jin, Xianhong Gu   +5 more
doaj   +1 more source

Lowering of lysophosphatidylcholines in ovariectomized rats by Curcuma comosa.

PLoS ONE, 2022
Decline of ovarian function in menopausal women increases metabolic disease risk. Curcuma comosa extract and its major compound, (3R)-1,7-diphenyl-(4E,6E)-4,6-heptadien-3-ol (DPHD), improved estrogen-deficient ovariectomized (OVX) rat metabolic ...
Jetjamnong Sueajai, Nareerat Sutjarit, Nittaya Boonmuen, Saranya Auparakkitanon, Nantida Noumjad, Apichart Suksamrarn, Nawaporn Vinayavekhin, Pawinee Piyachaturawat   +7 more
doaj   +1 more source

Fetal Exposure to Maternal Smoking and Neonatal Metabolite Profiles

Metabolites, 2022
Fetal tobacco exposure has persistent effects on growth and metabolism. The underlying mechanisms of these relationships are yet unknown. We investigated the associations of fetal exposure to maternal smoking with neonatal metabolite profiles.
Kim N. Cajachagua-Torres, Sophia M. Blaauwendraad, Hanan El Marroun, Hans Demmelmair, Berthold Koletzko, Romy Gaillard, Vincent W. V. Jaddoe   +6 more
doaj   +1 more source

Synthesis of Lysophosphatidylcholine and Mixed Phosphatidylcholine [PDF]

The Journal of Organic Chemistry, 2022
Lysophosphatidylcholine (LPC) and phosphatidylcholine (PC) are important membrane constituents implicated in signaling and immune regulation. Synthesis of LPCs is challenging due to rapid acyl migration, e.g., induced by chromatography. We here report a highly regioselective synthesis of LPC and mixed PC via an intermediate allowing specific terminal ...
Athanasios Papangelis, Trond Ulven
openaire   +3 more sources

Generation and characterization of a mitotane-resistant adrenocortical cell line [PDF]

, 2020
Mitotane is the only drug approved for the therapy of adrenocortical carcinoma (ACC). Its clinical use is limited by the occurrence of relapse during therapy.
Bachmann, Sebastian, Bahethi, Rohini, Beule, Dieter, Choi, Murim, Eisenhofer, Graeme, Liebisch, Gerhard, Messerschmidt, Clemens, Obermayer, Benedikt, Peitzsch, Mirko, Scholl, Ute I., Schrade, Petra, Seidel, Eric, Walenda, Gudrun, Wallace, Paal, Yoo, Taekyeong   +14 more
core   +2 more sources

Discovery of Infection Associated Metabolic Markers in Human African Trypanosomiasis [PDF]

, 2015
Peer reviewedPublisher ...
Alibu, Vincent Pius, Gomez-Romero, Maria, Holmes, Elaine, Lamour, Sabrina D, Saric, Jasmina, Sternberg, Jeremy M, Vorkas, Pangiotis A   +6 more
core   +4 more sources

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes [PDF]

, 2012
BACKGROUND: Obesity and type 2 diabetes (T2DM) are associated with increased circulating free fatty acids and triacylglycerols. However, very little is known about specific molecular lipid species associated with these diseases.
AD Karelis, Christine Yang, Clinton R. Bruce, EAH Sims, EP Rhee, F Samad, F Xing, G Boden, GM Reaven, GS Hotamisligil, H Cao, Hironori Waki, I Smyth, J Graessler, JM Haus, K Yea, KH Pietiläinen, L Wang, M Qatanani, Margaret Staples, Mark A. Febbraio, Melissa N. Barber, MS Han, N Barbarroja, N Tanaka, Peter J. Meikle, PJ Meikle, PJ Meikle, RA Rabini, RM Bernstein, Steve Risis, U Schwab, V Kus, VB Matthews, X Zhao, Y Xu, Y Xu   +36 more
core   +3 more sources

Comprehensive lipidomics reveals phenotypic differences in hepatic lipid turnover in ALD and NAFLD during alcohol intoxication⋆

JHEP Reports, 2021
Background & Aims: In experimental models, alcohol induces acute changes in lipid metabolism that cause hepatocyte lipoapoptosis and inflammation. Here we study human hepatic lipid turnover during controlled alcohol intoxication.
Mads Israelsen, Min Kim, Tommi Suvitaival, Bjørn Stæhr Madsen, Camilla Dalby Hansen, Nikolaj Torp, Kajetan Trost, Maja Thiele, Torben Hansen, Cristina Legido-Quigley, Aleksander Krag   +10 more
doaj   +1 more source