Results 41 to 50 of about 7,531 (229)

Metabolic Signatures of Lung Cancer in Biofluids: NMR-Based Metabonomics of Blood Plasma [PDF]

, 2011
In this work, the variations in the metabolic profile of blood plasma from lung cancer patients and healthy controls were investigated through NMR-based metabonomics, to assess the potential of this approach for lung cancer screening and diagnosis.
Ana Gomes, Ana M. Gil, António S. Barros, Asiago V. M., Bathe O. F., Bell J. D., Brian J. Goodfellow, Brière J.-J., Carrola J., Cláudia M. Rocha, Daykin C. A., Dong J., Duarte I. F., Duarte I. F., Erol A., Fan T. W. M., Fiorenza A. M., Fiorenza A. M., Freedman D. S., Gao H., Gao H. C., Gu H. W., Haffner H. T., Heber D., Iola F. Duarte, Isabel M. Carreira, Joana Carrola, João Bernardo, Jordan K. W., Keun H. C., Kochhar S., Lai H.-S., Laiakis E. C., Lin L., Lina Carvalho, Liu M., Lokhov P. G., Ludwig C., Ma Y., MacIntyre D. A., Maeda J., Muntoni S., Naini A. B., Norton J. A., Okamoto N., Pirozynski M., Psychogios N., Qiu Y. P., Ritchie S. A., Rocha C. M., Sitter B., Spratlin J. L., Sreekumar A., Stringer K. A., Thysell E., Tiziani S., Travis W. D., Trygg J., Urayama S., Vitor Sousa, Xu Q. S., Xue R., Yin P., Zhang J. A., Zhang Z. Y., Zhou J., Zira A. N.   +66 more
core   +2 more sources

Lysophosphatidylcholine-cholesterol complex.

Journal of Biological Chemistry, 1982
Lysophosphatidylcholine (lysoPC) and cholesterol at 1:1 molar ratio form multilamellar and, on sonication, unilamellar liposomes in water. Calorimetric scannings of varied mixtures in water give evidence for the existence of a 1:1 complex of the lipids.
L S, Ramsammy, H, Brockerhoff
openaire   +2 more sources

Lysophosphatidylcholine Drives Neuroblast Cell Fate

Molecular Neurobiology, 2015
Neuronal differentiation plays a key role during embryogenesis. However, based on the capacity of neuronal stem cells to either generate or regenerate neurons and because differentiation stops aberrant neuroblasts proliferation, neuronal differentiation is crucial during neuropathological conditions.
Paoletti, Luciana Elisa, Domizi, Pablo Daniel, Marcucci, Hebe Josefina, Montaner, Aneley Natalia, Krapf, Dario, Salvador, Gabriela Alejandra, Banchio, Claudia Elena   +6 more
openaire   +3 more sources

Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles [PDF]

, 2013
Background: Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) that associate with clinical phenotypes, but these SNPs usually explain just a small part of the heritability and have relatively modest
Adamski, J. (Jerzy), Aulchenko, Y.S. (Yurii), Axenovich, T.I. (Tatiana), Biloglav, Z. (Zrinka), Broer, L. (Linda), Campbell, H. (Harry), Campbell, S. (Susan), Demirkan, A. (Ayşe), Dharuri, H. (Harish), Domingues, I. (Inês), Duijn, C.M. (Cornelia) van, Floyd, J. (Jamie), Franke, L. (Lude), Franklin, C.S. (Christopher), Gieger, C. (Christian), Gnewuch, C. (Carsten), Gyllensten, U. (Ulf), Hastie, N. (Nick), Hayward, C. (Caroline), Henneman, P. (Peter), Hettne, K.M. (Kristina), Hicks, A.A. (Andrew), Hoen, P.A.C. (Peter) 't, Hofman, A. (Albert), Huffman, J.E. (Jennifer), Igl, W. (Wilmar), Isaacs, A.J. (Aaron), Jansen, R.C. (Ritsert), Janssens, A.C.J.W. (Cécile), Johansson, A. (Åsa), Jonasson, I. (Inger), Karssen, L.C. (Lennart), Kirichenko, A.V. (Anatoly), Klinken, J.B. (Jan) van, Kolcic, I. (Ivana), Liebisch, G. (Gerhard), Meitinger, T. (Thomas), Mook-Kanamori, D.O. (Dennis), Oostra, B.A. (Ben), Pattaro, C. (Cristian), Pfeufer, A. (Arne), Pichler, I. (Irene), Polasek, O. (Ozren), Pramstaller, P.P. (Peter Paul), Rivadeneira Ramirez, F. (Fernando), Roos, M. (Marco), Rudan, I. (Igor), Schmitz, G. (Gerd), Struchalin, M.V. (Maksim), Suhre, K. (Karsten), Ugocsai, P. (Peter), Uitterlinden, A.G. (André), Vitart, V. (Veronique), Wang-Sattler, R. (Rui), Wild, S.H. (Sarah), Willems van Dijk, J.A.P. (Ko), Wilson, J.F. (James F), Witteman, J.C.M. (Jacqueline), Wright, A.F. (Alan), Zaboli, G. (Ghazal), Zorkoltseva, I.V. (Irina)   +60 more
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Immunomodulatory Actions of Lysophosphatidylcholine [PDF]

Biomolecules and Therapeutics, 2008
Lysophosphatidylcholine (LPC) is an endogenous phospholipid. LPC has various stimulating or modulating activities on immune cells, including lymphocytes, monocytes/macrophages and neutrophils. Stud- ies generally revealed pro-inflammatory activities of LPC, but accumulating evidence indicates that LPC has also anti-inflammatory actions.
Chang-Won Hong, Dong-Keun Song
openaire   +1 more source

Metabolomic profiling of women with gestational diabetes mellitus and their offspring: Review of metabolomics studies. [PDF]

, 2018
BACKGROUND:Gestational diabetes mellitus (GDM) reflects an increased risk of developing type 2 diabetes (T2D) after pregnancy in women. Offspring born to mothers with GDM are at an elevated risk of obesity and T2D at a young age.
Chen, Liwei, Chen, Qian, Francis, Ellen, Hu, Gang   +3 more
core   +1 more source

Maternal and fetal metabolomic signatures in regard to birth outcome and gestational disease [PDF]

, 2018
Specific birth outcomes and gestational diabetes were shown to be associated with maternal and fetal metabolic alterations. Results of the current studies showed a higher number of associations between birth outcomes/gestational disease and fetal ...
Lu, YongPing
core   +1 more source

Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines' unexpected therapeutic properties

Journal of Inflammation, 2008
Background Lysophosphatidylcholines (lysoPCs) are products of phospholipase A2 (PLA2) enzyme activity, and like the enzyme, have a direct role in toxic inflammatory responses in variety of organ systems.
Lucena Angel, Yao Lihua, Cunningham Timothy J   +2 more
doaj   +1 more source

Defining Acute Coronary Syndrome through Metabolomics

Metabolites, 2021
As an emerging platform technology, metabolomics offers new insights into the pathomechanisms associated with complex disease conditions, including cardiovascular diseases.
Arun Surendran, Negar Atefi, Hannah Zhang, Michel Aliani, Amir Ravandi   +4 more
doaj   +1 more source

Metabolomics reveals LysoPC a C17:0 (LPC 17:0) as candidate biomarker for personalized medicine in morbid obesity

Frontiers in Medicine
Morbid obesity represents the most severe form of obesity and is associated with increased cardiometabolic risk, including type 2 diabetes and cardiovascular complications. Current diagnostic approaches rely on anthropometric measures, failing to capture
Eleonora Stefanini, Silvia Marin, Silvia Marin, Silvia Marin, Joan Serrano-Marín, Juan Sánchez-Navés, Hanan Awad Alkozi, Mercè Pallàs, Mercè Pallàs, Mercè Pallàs, Marta Cascante, Marta Cascante, Marta Cascante, Christian Griñán-Ferré, Christian Griñán-Ferré, Christian Griñán-Ferré, Rafael Franco, Rafael Franco, Rafael Franco   +18 more
doaj   +1 more source