Results 41 to 50 of about 7,434 (235)

Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines' unexpected therapeutic properties

Journal of Inflammation, 2008
Background Lysophosphatidylcholines (lysoPCs) are products of phospholipase A2 (PLA2) enzyme activity, and like the enzyme, have a direct role in toxic inflammatory responses in variety of organ systems.
Lucena Angel, Yao Lihua, Cunningham Timothy J   +2 more
doaj   +1 more source

Defining Acute Coronary Syndrome through Metabolomics

Metabolites, 2021
As an emerging platform technology, metabolomics offers new insights into the pathomechanisms associated with complex disease conditions, including cardiovascular diseases.
Arun Surendran, Negar Atefi, Hannah Zhang, Michel Aliani, Amir Ravandi   +4 more
doaj   +1 more source

Action mechanism of hypoglycemic principle 9-(R)-HODE isolated from cortex lycii based on a metabolomics approach

Frontiers in Pharmacology, 2022
The 9-(R)-HODE is an active compound isolated from cortex lycii that showed significant hypoglycemic effects in our previous in vitro study. In this study, 9-(R)-HODE’s in vivo hypoglycemic activity and effect on alleviating diabetic complications ...
Yueqiu Liu, Yueqiu Liu, Xinyi Hu, Wen Zheng, Lu Zhang, Luolan Gui, Ge Liang, Yong Zhang, Liqiang Hu, Xin Li, Yi Zhong, Tao Su, Xin Liu, Jingqiu Cheng, Meng Gong   +14 more
doaj   +1 more source

Hepatocellular carcinoma: Review of disease and tumor biomarkers. [PDF]

, 2016
© The Author(s) 2016.Hepatocellular carcinoma (HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative
Cox, IJ, Crossey, MM, Fye, HK, Gomez-Romero, M, Holmes, E, Kim, JU, Njie, R, Shariff, MI, Taylor-Robinson, SD   +8 more
core   +1 more source

Plasma lipid profiling for the prognosis of 90-day mortality, in-hospital mortality, ICU admission, and severity in bacterial community-acquired pneumonia (CAP)

Critical Care, 2020
Introduction Pneumonia is the most common cause of mortality from infectious diseases, the second leading cause of nosocomial infection, and the leading cause of mortality among hospitalized adults.
Mohammad M. Banoei, Hans J. Vogel, Aalim M. Weljie, Sachin Yende, Derek C. Angus, Brent W. Winston   +5 more
doaj   +1 more source

Metabolic profiling reveals interleukin-17A monoclonal antibody treatment ameliorate lipids metabolism with the potentiality to reduce cardiovascular risk in psoriasis patients

Lipids in Health and Disease, 2021
Background Psoriasis is a common chronic inflammatory skin disease associated with overproduction of interleukin-17A (IL-17A). IL-17A monoclonal antibodies (mAbs) have shown clinical efficacy in psoriasis patients.
Han Cao, Shengmin Su, Qi Yang, Yunchen Le, Lihong Chen, Mengyan Hu, Xiaoyu Guo, Jie Zheng, Xia Li, Yunqiu Yu   +9 more
doaj   +1 more source

Metabolomic profiling of women with gestational diabetes mellitus and their offspring: Review of metabolomics studies. [PDF]

, 2018
BACKGROUND:Gestational diabetes mellitus (GDM) reflects an increased risk of developing type 2 diabetes (T2D) after pregnancy in women. Offspring born to mothers with GDM are at an elevated risk of obesity and T2D at a young age.
Chen, Liwei, Chen, Qian, Francis, Ellen, Hu, Gang   +3 more
core   +1 more source

Acacetin Attenuates Lysophosphatidylcholine-Induced Vascular Smooth Muscle Cell Injury via Sirt1-Nrf2/p62 Signaling Axis

Biomedicines
Background: Acacetin, a naturally occurring flavone present in various plants, is known as a promising drug candidate for cardiovascular disorders.
Yun-Da Li, Yao Wu, Tian-Li Zhou, Qian Yuan, Gui-Rong Li, Wei-Yin Wu, Yan Wang, Gang Li   +7 more
doaj   +1 more source

Gut opportunistic pathogens contribute to high-altitude pulmonary edema by elevating lysophosphatidylcholines and inducing inflammation

Microbiology Spectrum
Gut microbiota have been found to promote hypoxia-induced intestinal injury. However, the role of gut microbiota in high-altitude pulmonary edema (HAPE), the preventive effect of synbiotic on HAPE, and the mechanisms by which they might work remain ...
Xianduo Sun, Gaosheng Hu, Yuting Li, Wenjing Li, Yong Wang, Hui Yan, Guoqing Long, Long Zhao, Anhua Wang, Jingming Jia   +9 more
doaj   +1 more source

Distinct subsets of neutrophils crosstalk with cytokines and metabolites in patients with sepsis

iScience, 2023
Summary: Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Despite continued efforts to understand the pathophysiology of sepsis, no effective therapies are currently available.
Upasana Parthasarathy, Yi Kuang, Gunjan Thakur, John D. Hogan, Thomas P. Wyche, James E. Norton, Jr., Jason R. Killough, Theodore R. Sana, Caroline Beakes, BaoJen Shyong, Rena N. Zhang, Dario A. Gutierrez, Michael Filbin, David C. Christiani, Alex G. Therien, Christopher H. Woelk, Cory H. White, Roberta Martinelli   +17 more
doaj   +1 more source