Results 131 to 140 of about 17,757 (160)

Chaperone-like Properties of Lysophospholipids

Biochemical and Biophysical Research Communications, 2001
Lysophospholipids are metabolic intermediates in phospholipid turnover, detergent molecules with membrane-modulating effects, and multifunctional cellular growth factors in eukaryotic cells. In bacterial cells, lysophospholipids are mostly found in the form of lysophosphatidylethanolamine.
R, Kern, D, Joseleau-Petit, M K, Chattopadhyay, G, Richarme   +3 more
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Lysophospholipids as biosurfactants

Colloids and Surfaces, 1987
Abstract Lysophospholipids are surface-active amphiphiles generated naturally in biological membranes by the action of phospholipases. These surfactants contain only one long chain fatty acyl group and therefore have much higher critical micelle concentrations than the parent phospholipids.
Richard E. Stafford, Edward A. Dennis
openaire   +1 more source

Biological effects of lysophospholipids

2006
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are potent biologically active lipid mediators that exert a wide range of cellular effects through specific G protein-coupled receptors. To date, four LPA receptors and five S1P receptors have been identified.
R, Rivera, J, Chun
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Biological functions of bacterial lysophospholipids

2023
Lysophospholipids (LPLs) are lipid-derived metabolic intermediates in the cell membrane. The biological functions of LPLs are distinct from their corresponding phospholipids. In eukaryotic cells LPLs are important bioactive signaling molecules that regulate many important biological processes, but in bacteria the function of LPLs is still not fully ...
Cao, Xuefeng, van Putten, Jos P.M., Wösten, Marc M.S.M.   +2 more
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Lysophospholipid variants in hepatocellular carcinoma

Journal of Surgical Research, 2013
The U.S. incidence of hepatocellular carcinoma (HCC) is increasing and is linked to hepatitis C (HepC) infection, alcohol toxicity, and obesity. This manuscript examines lysophosphatidic acid (LPA) variant biosynthesis as a biomarker and potential therapeutic target for HCC.Serum LPA variant levels were determined in patients with HepC ± HCC, alcoholic
Nicholas J, Skill, Wu, Jianmin, Xu, Yan, Zhenweng, Zhao, Alfred J, Tector, Mary A, Maluccio   +5 more
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Lysophospholipid Receptors: Signaling and Biology

Annual Review of Biochemistry, 2004
▪ Abstract  Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental cellular functions, which include proliferation, differentiation, survival, migration, adhesion, invasion, and morphogenesis.
Isao, Ishii, Nobuyuki, Fukushima, Xiaoqin, Ye, Jerold, Chun   +3 more
openaire   +2 more sources

Towards selective lysophospholipid GPCR modulators

Trends in Pharmacological Sciences, 2014
G-protein-coupled receptors (GPCRs) that recognize the lysophospholipids (LPLs) are grouped into two phylogenetically distinct families: the endothelial differentiation gene (Edg) and non-Edg GPCRs. Owing to their more recent identification, and hindered by a lack of selective pharmacological tools, our understanding of the functions and signaling ...
Archbold, Julia K., Martin, Jennifer L., Sweet, Matthew J.   +2 more
openaire   +3 more sources

Lysophospholipid receptors in cell signaling

Biochemistry (Moscow), 2007
There is increasing evidence that different phospholipids are involved in regulation of various cell processes and cell-cell interactions. Lysophospholipids (lysophosphatidic acid, lysophosphatidylcholine) and a number of lysosphingolipids play particular roles in these regulations. Their effects are mediated by specific G-protein-coupled receptors.
T I, Torkhovskaya, O M, Ipatova, T S, Zakharova, M M, Kochetova, E M, Khalilov   +4 more
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Lysophospholipids and the cardiovascular system

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) have varied effects on the cardiovascular system. S1P is necessary for normal vascular development and may play an important role in angiogenesis. These molecules may exert potentially detrimental effects.
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Stem cell regulation by lysophospholipids

Prostaglandins & Other Lipid Mediators, 2007
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) regulate a diverse range of mammalian cell processes, largely through engaging multiple G protein-coupled receptors specific for these lysophospholipids. LPA and S1P have been clearly identified to have widespread physiological and pathophysiological actions, controlling events within the ...
Pebay, A., Bonder, C., Pitson, S.
openaire   +3 more sources