Results 171 to 180 of about 18,174 (203)

Lysophospholipids--Receptor Revelations

Science, 2001
Upon cell activation, membrane phospholipids are metabolized into potent lysophospholipid (LP) mediators, such as sphingosine 1-phosphate and lysophosphatidic acid. LPs fulfill signaling roles in organisms as diverse as yeast and humans. The recent discovery of G protein–coupled receptors for LPs in higher eukaryotes, and their involvement in ...
T, Hla, M J, Lee, N, Ancellin, J H, Paik, M J, Kluk   +4 more
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Druggable Lysophospholipid Signaling Pathways

2020
Lysophosphatidic acid (LPA) has major roles as a bioactive signaling molecule, with multiple physiological and pathological roles being described in almost every major organ system. In this review we discuss LPA signaling pathways as emerging drug targets for multiple conditions relevant to human health and disease.
Keisuke, Yanagida, William J, Valentine
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Lysophospholipids in Lung Inflammatory Diseases

2021
The lysophospholipids (LPLs) belong to a group of bioactive lipids that play pivotal roles in several physiological and pathological processes. LPLs are derivatives of phospholipids and consist of a single hydrophobic fatty acid chain, a hydrophilic head, and a phosphate group with or without a large molecule attached.
Jing, Zhao, Yutong, Zhao
openaire   +2 more sources

Chaperone-like Properties of Lysophospholipids

Biochemical and Biophysical Research Communications, 2001
Lysophospholipids are metabolic intermediates in phospholipid turnover, detergent molecules with membrane-modulating effects, and multifunctional cellular growth factors in eukaryotic cells. In bacterial cells, lysophospholipids are mostly found in the form of lysophosphatidylethanolamine.
R, Kern, D, Joseleau-Petit, M K, Chattopadhyay, G, Richarme   +3 more
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Lysophospholipids as biosurfactants

Colloids and Surfaces, 1987
Abstract Lysophospholipids are surface-active amphiphiles generated naturally in biological membranes by the action of phospholipases. These surfactants contain only one long chain fatty acyl group and therefore have much higher critical micelle concentrations than the parent phospholipids.
Richard E. Stafford, Edward A. Dennis
openaire   +1 more source

Biological effects of lysophospholipids

2006
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are potent biologically active lipid mediators that exert a wide range of cellular effects through specific G protein-coupled receptors. To date, four LPA receptors and five S1P receptors have been identified.
R, Rivera, J, Chun
openaire   +2 more sources

Biological functions of bacterial lysophospholipids

2023
Lysophospholipids (LPLs) are lipid-derived metabolic intermediates in the cell membrane. The biological functions of LPLs are distinct from their corresponding phospholipids. In eukaryotic cells LPLs are important bioactive signaling molecules that regulate many important biological processes, but in bacteria the function of LPLs is still not fully ...
Cao, Xuefeng, van Putten, Jos P.M., Wösten, Marc M.S.M.   +2 more
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Lysophospholipid variants in hepatocellular carcinoma

Journal of Surgical Research, 2013
The U.S. incidence of hepatocellular carcinoma (HCC) is increasing and is linked to hepatitis C (HepC) infection, alcohol toxicity, and obesity. This manuscript examines lysophosphatidic acid (LPA) variant biosynthesis as a biomarker and potential therapeutic target for HCC.Serum LPA variant levels were determined in patients with HepC ± HCC, alcoholic
Nicholas J, Skill, Wu, Jianmin, Xu, Yan, Zhenweng, Zhao, Alfred J, Tector, Mary A, Maluccio   +5 more
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Lysophospholipid Receptors: Signaling and Biology

Annual Review of Biochemistry, 2004
▪ Abstract  Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental cellular functions, which include proliferation, differentiation, survival, migration, adhesion, invasion, and morphogenesis.
Isao, Ishii, Nobuyuki, Fukushima, Xiaoqin, Ye, Jerold, Chun   +3 more
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Towards selective lysophospholipid GPCR modulators

Trends in Pharmacological Sciences, 2014
G-protein-coupled receptors (GPCRs) that recognize the lysophospholipids (LPLs) are grouped into two phylogenetically distinct families: the endothelial differentiation gene (Edg) and non-Edg GPCRs. Owing to their more recent identification, and hindered by a lack of selective pharmacological tools, our understanding of the functions and signaling ...
Archbold, Julia K., Martin, Jennifer L., Sweet, Matthew J.   +2 more
openaire   +3 more sources